Lung clinical trials

INK cells after chemoradiation for small cell lung cancer

This trial tests whether adding a special immune cell called iNK cells after standard chemoradiation can help keep small cell lung cancer from coming back.

Lung disease study in children: new ways to understand infections

This study explores how the immune system and lung microbes affect children with lung disease. It uses extra fluid collected during a standard lung exam to look for new treatment targets.

How well do targeted drugs work for EGFR lung cancer?

This trial studies whether changes in tiny particles in your blood (called exosomes) can show how well targeted therapy is working for lung cancer with an EGFR mutation. You may be eligible if you have this type of lung cancer and are starting your first treatment with a targeted drug.

Maintenance therapy for HRD-positive small-cell lung cancer

This trial tests whether a combination of two medications, durvalumab and olaparib, can help keep your extensive-stage small-cell lung cancer from coming back after standard first-line treatment. It is for people whose tumors have a specific genetic feature called HRD.

Lung cancer screening follow-up study

This study is testing whether a centralized support program helps people get regular lung cancer screening. If you are at risk for lung cancer and have had a screening CT scan at one of the participating health centers, this study may help improve care.

T-DXd for HER2-mutant lung cancer with brain metastases

This trial tests a drug called T-DXd in people with advanced non-squamous lung cancer that has a specific HER2 gene change (mutation) and has spread to the brain but isn't causing symptoms. The goal is to see if the drug can shrink tumors and help control the cancer.

Lung ultrasound check for breathing problems in very premature babies

This trial tests whether doing a bedside lung ultrasound can help doctors assess and manage breathing problems in very premature infants. It may help guide care decisions for infants who are struggling to breathe, especially those needing breathing support.

Italian lung cancer study observing care and outcomes

This is an observational study of people with lung cancer. The goal is to better understand care patterns and outcomes; joining would involve giving consent and answering study questions.

Lung transplant registry for better donor lung preservation

This study builds a worldwide database to track and improve how donor lungs are preserved before transplant. Your information may help doctors choose and manage donor lungs more effectively.

Natural history study for lung scarring patients

This study follows people who are being seen for lung scarring (also called ILD) and compares them with family members without lung scarring. It helps researchers better understand how this condition changes over time and what to look for in the future.

Almonertinib after lung tumor surgery, with or without chemo

This study tests whether almonertinib taken after complete surgery can improve outcomes for people with stage II–IIIA non-small cell lung cancer (NSCLC) that has certain EGFR gene changes. It also compares almonertinib plus chemotherapy versus almonertinib alone to see which approach is safer and works better.

Test lung cancer samples outside the body during surgery

This study looks at lung cancer tissue after surgery, using lab testing done outside the body. It may help researchers better observe and study lung tumors using samples taken during lobectomy or segment removal.

Study to categorize lung fibrosis types at a clinic

This study enrolls people who have interstitial lung disease and are seen at the Edinburgh lung fibrosis clinic. It aims to sort different underlying “types” of lung fibrosis so doctors can better understand and potentially guide care.

Use of chest CT scans from WTC Health Plan participants

This study creates a research archive of chest CT scan images from people enrolled in the World Trade Center (WTC) Health Plan program at Mount Sinai. It may help doctors and researchers better understand and track chest health over time using existing scan images.

Analyzing DNA from blood and lung tumor tissue

This study looks at DNA from blood samples and lung tumor tissue in people newly diagnosed with primary lung cancer. The goal is to learn more about the cancer’s biology and possibly guide better future care.

Personalized breathing settings for ECMO patients

This study tests whether personalized breathing machine settings can improve outcomes for people on ECMO (a heart-lung support machine). It is designed for patients who have had or are waiting for a lung or heart transplant.

Comparing low vs high breathing tube pressure on diaphragm health

This trial compares two levels of positive end-expiratory pressure (PEEP) in patients on a breathing machine. It looks at how these pressures affect diaphragm function, how well the lungs work, and how efficiently you breathe.

Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women

Blood test study for early cancer detection

This study is testing a new blood test that may help find cancer early. You will give blood samples over a year, and researchers will check them for signs of cancer.

Study of pembrolizumab plus MK-1084 for KRAS G12C lung cancer

This trial tests a combination of two drugs for people with advanced non-small cell lung cancer that has a specific mutation called KRAS G12C. The goal is to see if the combination works better than current treatments.

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

A study of heart failure patterns (MAP-HEART)

This study looks at different types of heart failure to understand them better. You may join if you have active heart failure (with symptoms like shortness of breath or swelling) and are willing to participate in research activities.

A new way to treat stubborn heart rhythm problems

This study tests a special navigation technique to improve the success of repeat catheter ablation for ventricular arrhythmias, helping patients who haven't been helped by prior procedures or medications.

Test “BetterEveryDay” patient-reported care for pancreatic or bile cancer

This study studies how a patient “reporting” program (called PRO) works for people with advanced pancreatic or bile-tract cancer. It may help teams understand symptoms and needs earlier to improve care and support during treatment.