Clinical trials
MDD clinical trials
Below are recruiting mdd clinical trials, each written for real people, not researchers. We’re tracking 103 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06982820Recruiting
Brain training therapy for depression with loss of interest
This trial tests a new type of brain training (self-neuromodulation) to help people with major depression who also have a significant loss of interest or pleasure (anhedonia). If you qualify, you may get a non-invasive treatment that uses real-time brain feedback to improve symptoms.
Providence, Rhode IslandAges 22–75 - NCT06976697Recruiting
Home-based tDCS for major depression
This trial tests a home-use device that sends a small electrical current to the brain to treat major depression. It may be a good option if you are already on antidepressant medication and have a smartphone.
Boston, MassachusettsAges 22–70 - NCT06966401RecruitingPhase 3
Long-term safety study of a new depression treatment
This study tests a new oral medication (NBI-1065845) added to your current antidepressant to see if it's safe and tolerable over a long period for people with depression that hasn't fully responded to treatment.
Huntsville, AlabamaAges 18 years+ - NCT06963021RecruitingPhase 3
Study of NBI-1065845 for depression that hasn't fully responded to treatment
This trial tests an investigational drug called NBI-1065845 added to your current antidepressant. It is for people with moderate to severe depression or persistent depressive disorder who have not improved enough with oral antidepressants alone.
Chino, CaliforniaAges 18 years+ - NCT06972368Recruiting
Home brain stimulation for depression in borderline personality disorder
This trial tests whether a gentle brain stimulation device (tDCS) used at home can help with depression in people with borderline personality disorder. If you have BPD and current depression, you may be able to participate from home using your smartphone.
Montreal, QuebecAges 18–65 - NCT06911112RecruitingPhase 3
A new pill for depression when current treatment isn't working well enough
This trial tests an investigational medication (NBI-1065845) added to your current antidepressant to see if it can improve depressive symptoms. It is for people with moderate to severe depression who have not fully responded to their current antidepressant.
Huntsville, AlabamaAges 18 years+ - NCT06891300RecruitingPhase 2/Phase 3
Ketamine for Suicidal Thoughts in Depression
This study tests if ketamine can help reduce suicidal thoughts in people with major depression. You'll receive ketamine treatment and be monitored closely.
Ottawa, OntarioAges 18–65 - NCT06860165Recruiting
Mood tracking app study for adults with depression
This study tests a smartphone app (EmoDTx) that monitors mood in people with unipolar depression. It aims to see if the app can provide helpful digital measurements of your mood.
Changé, FranceAges 18 years+ - NCT06854224RecruitingPhase 2
Testing a sleep drug for suicide risk in veterans with depression
This trial tests whether a medication called suvorexant (used for sleep) can help lower suicide risk in veterans who have major depression and have attempted suicide before. The study aims to see if blocking a brain chemical called orexin reduces suicidal thoughts.
The Bronx, New YorkAges 18–70 - NCT06830044RecruitingPhase 3
Adding an experimental drug for major depression
This trial tests if adding a new medicine called milsaperidone can help people with major depression who haven't gotten enough relief from their current antidepressant. It aims to see if the combination works better than the antidepressant alone.
Phoenix, ArizonaAges 18–65 - NCT06821646Enrolling by invitation
Brain responses in depression and autism with TMS and EEG
This study uses brain stimulation (TMS) and brain wave recording (EEG) to understand how the brain works in people with autism, depression, or both. It may help find better ways to treat these conditions.
TaipeiAges 20–50 - NCT06804525Recruiting
Adapting a mental health survey in Hong Kong
This study adapts a mental health survey for Hong Kong adults. It is open to adults aged 25 and older who live in randomly selected households and can speak Chinese or English.
Hong KongAges 25 years+ - NCT06793397RecruitingPhase 3
Study of an experimental psychedelic-like drug for depression (CYB003)
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Birmingham, AlabamaAges 18–85 - NCT06795451RecruitingPhase 1/Phase 2
Spinal stimulation for depression: a clinical trial
This study tests if a non-invasive spinal stimulation device can improve depression symptoms. It is for people currently taking an antidepressant for at least 8 weeks but still experiencing depression.
Mason, OhioAges 18–60 - NCT06786624RecruitingPhase 3
Testing a new drug for depression that hasn't fully responded to treatment
This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.
Little Rock, ArkansasAges 18 years+ - NCT06788249RecruitingEarly Phase 1
Ketamine for treatment-resistant depression brain study
This trial tests whether a single dose of ketamine can quickly improve depression by studying brain chemical changes using MRI. It's for people with treatment-resistant depression who haven't used ketamine before.
Philadelphia, PennsylvaniaAges 25–65 - NCT06782724RecruitingPhase 2
Psilocybin therapy for distress in advanced illness
This trial tests whether a single dose of psilocybin (a psychedelic medicine) can help reduce depression and distress in people with advanced lung disease, ALS, multiple sclerosis, or Parkinson's. You would receive preparation, the drug, and follow-up support in a safe, supervised setting.
PragueAges 18 years+ - NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Phoenix, ArizonaAges 18–70 - NCT06773949Recruiting
Exercise before rTMS for hard-to-treat depression
This trial tests if doing exercise before repetitive transcranial magnetic stimulation (rTMS) can improve depression symptoms in people who haven't gotten better with standard treatments.
Ottawa, OntarioAges 18–75 - NCT06746155Recruiting
Predictors of relapse in major depression
This study looks at adults with major depressive disorder who have responded to treatment, to find out what might predict a relapse. You will wear a wrist activity monitor and complete questionnaires.
Calgary, AlbertaAges 18–70 - NCT06698666RecruitingPhase 3
Can statins help treat depression?
This trial tests if adding a statin (a cholesterol-lowering medicine) to your current depression treatment improves symptoms. It is for adults aged 20 to 45 with mild to moderate depression who are not already taking a statin.
Cairo, Al AbbasiaAges 20–45 - NCT06692361Recruiting
Gut bacteria transplant for depression not helped by escitalopram
This trial tests whether transplanting healthy gut bacteria (fecal microbiota) can help people with depression that does not respond well to the antidepressant escitalopram. You will first take escitalopram for 2 weeks, and if it doesn't help enough, you may receive either the real transplant or a placebo capsule.
Wuhu, AnhuiAges 18–65 - NCT06605105Enrolling by invitationPhase 3
Long-term extension trial of CYB003 for depression
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
Phoenix, ArizonaAges 18–85 - NCT06601140Recruiting
Testing a smartphone app for tracking depression symptoms
This study tests a smartphone-based emotional monitoring device (EMOCARE) to see if it can accurately measure your mood compared to a standard depression questionnaire. It may help researchers find a simpler way to track depression symptoms.
AgenAges 18 years+
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Common questions
- Are there clinical trials for mdd?
- Yes. Clin2 currently lists 103 recruiting mdd studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mdd trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mdd trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.