Clinical trials
Melatonin clinical trials
Below are recruiting melatonin clinical trials, each written for real people, not researchers. We’re tracking 64 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04547439RecruitingPhase 2
Melatonin for diabetic eye disease and better sleep
This Phase 2 study tests whether melatonin can improve sleep and possibly outcomes related to diabetic retinopathy (damage to the retina from diabetes). It also checks whether it affects related symptoms while keeping people safe.
Chicago, IllinoisAges 40–65 - NCT03954899Recruiting
Melatonin test for brain health in older adults
This study tests whether taking 5 mg of melatonin can improve thinking and brain health over time in older adults with early, mild symptoms. You may help researchers learn which brain changes and measures improve with melatonin.
Iowa City, IowaAges 56–85 - NCT02621944RecruitingEarly Phase 1
Melatonin for newborns with brain injury after oxygen problems
This early study tests whether giving melatonin to newborns with hypoxic-ischemic encephalopathy (brain injury from not enough oxygen around birth) can help protect the brain while they are cooled (therapeutic hypothermia). It may be most relevant if your baby shows early brain-injury signs and meets specific blood test and birth-history timing criteria.
Gainesville, FloridaAges Up to 6 hours - NCT07853976Recruiting
UV-treated dental implants with or without melatonin
This study tests two types of dental implant treatments for replacing missing back teeth in the upper jaw. One uses special UV light to clean the implant surface, and the other adds melatonin to help healing. It aims to see which works better for long-term success.
Al Mansurah, Dakahlia GovernorateAges 18–60 - NCT07554716Recruiting
Timing of Tube Feeding and Body Rhythms
This study looks at how the timing of tube feeding (enteral nutrition) throughout the day affects your body's natural sleep and wake cycles. Researchers want to understand if adjusting when you receive nutrition might help improve your sleep and overall health.
Málaga, MálagaAges 18 years+ - NCT06509191RecruitingPhase 2/Phase 3
Melatonin for preventing delirium in older hospital patients
This trial tests if giving melatonin (a natural sleep hormone) can help prevent delirium (sudden confusion) in older adults who are hospitalized. It may help you if you are 65 or older and admitted to the hospital for general medical care.
MuscatAges 65 years+ - NCT07336277RecruitingPhase 3
Sleep quality study for hospitalized orthopedic trauma patients
This study tests if a special sleep program can help people with leg or foot injuries sleep better in the hospital. It may show if treatments like zolpidem or melatonin help improve sleep after surgery.
Atlanta, GeorgiaAges 18–65 - NCT06236932Recruiting
Infection risk in obesity study
This study looks at how obesity and related conditions affect your body's ability to fight infections. It may help find ways to prevent illness in people with obesity.
NaplesAges 18–65 - NCT06687304Recruiting
Lighting effects on radiographers in hospitals
This trial studies how lighting in a hospital environment affects radiographers. It aims to understand if different lighting designs can improve comfort, well-being, or performance at work.
Lund, Skåne CountyAges 21 years+ - NCT06226025RecruitingPhase 2
Melatonin for Bipolar Disorder in Night Owls
This trial tests whether giving melatonin at the right time can help people with bipolar disorder who are night owls improve their mood and sleep. You would take melatonin or a placebo each evening for a few weeks while tracking your symptoms on a phone app.
Ann Arbor, MichiganAges 18–60 - NCT06104280Recruiting
How opioid addiction meds affect sleep and eyes
This study tests how three common medications for opioid use disorder (methadone, buprenorphine, and naltrexone) affect eye function, sleep, and daily body rhythms. It may help find ways to improve treatment for opioid addiction.
Birmingham, AlabamaAges 18–80 - NCT05878730Recruiting
Melatonin study for people stable on long-term lithium
This trial tests whether taking melatonin (a sleep-related hormone) changes how your body responds to lithium in people with bipolar disorder who are currently stable. It may help researchers understand lithium’s effects and how sleep/circadian timing could matter.
Paris, Île-de-France RegionAges 18–70 - NCT05617833RecruitingPhase 1
Test EPO and melatonin for brain bleeding in very preterm babies
This Phase 1 trial studies whether giving erythropoietin (EPO) and melatonin is safe in very preterm infants who have bleeding in the brain (intraventricular hemorrhage) or significant nearby brain injury. It aims to see if these medicines can be given safely during the early days after birth.
St. Petersburg, FloridaAges 12 hours–2 months - NCT05107947Recruiting
Dynamic room lighting to improve sleep and daily body rhythm
This study tests whether changing the light in a hospital room can improve sleep and help your body clock work better in older adults. It may be most helpful if sleep problems or irregular daily rhythms are affecting you in the hospital.
MalmöAges 65 years+ - NCT04400266RecruitingPhase 4
Buspirone and melatonin for depression after a brain injury
This trial studies whether the medicines buspirone and melatonin can reduce depression symptoms in people who had a mild or moderate traumatic brain injury (TBI) at least 3 months ago. It may help if you have ongoing depression after TBI and can safely take study medications and attend regular visits, including MRI scans.
Boston, MassachusettsAges 18–64 - NCT03438526RecruitingPhase 4
Melatonin treatment for low-activity delirium in ICU patients
This trial tests whether giving melatonin (or a placebo) can help adults in the intensive care unit who have a specific type of confusion called low-activity delirium. It aims to improve recovery by supporting sleep–wake regulation in the ICU.
BaselAges 55 years+
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Common questions
- Are there clinical trials for melatonin?
- Yes. Clin2 currently lists 64 recruiting melatonin studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a melatonin trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a melatonin trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.