Clinical trials
Melatonin clinical trials
Below are recruiting melatonin clinical trials, each written for real people, not researchers. We’re tracking 64 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07120880RecruitingPhase 3
Light therapy timing for depression with insomnia
This trial tests whether giving light therapy at a specific time of day can improve both depression and sleep problems. It is for adults with major depression and insomnia who are not currently on antidepressants.
ParisAges 18–65 - NCT07344467Recruiting
Melatonin vs. Pregabalin for pain and anxiety after spine surgery
This trial compares two medications—melatonin and pregabalin—to see which works better at reducing pain and anxiety after spine surgery. It aims to find a safer, effective option for recovery.
Tanta, El-GharbiaAges 21–60 - NCT07345715Recruiting
Melatonin vs. dexmedetomidine for preventing agitation after tonsil surgery in children
This study tests whether giving children either oral melatonin or a nebulized sedative (dexmedetomidine) before surgery can reduce confusion and restlessness (emergence agitation) when they wake up from anesthesia. It may help children recover more calmly after adenotonsillectomy.
Tanta, El-GharbiaAges 3–7 - NCT06768580Recruiting
Melatonin or lidocaine to prevent confusion after hip replacement
This trial tests if giving either oral melatonin or lidocaine during surgery can reduce the chance of confusion (delirium) in older adults after total hip replacement. It compares these two approaches to standard care.
Tanta, El-GharbiaAges 65 years+ - NCT07062757Enrolling by invitation
Massage and melatonin for jaw surgery recovery
This study tests whether combining gentle lymphatic drainage massage with melatonin can reduce pain and swelling after jaw surgery. If you are scheduled for jaw surgery for the first time and are otherwise healthy, you may be able to join.
Istanbul, FatihAges 16–55 - NCT06802913RecruitingEarly Phase 1
Inhaled melatonin for sleep problems in older adults
This trial tests a new inhaled form of melatonin to help adults aged 55 and older with insomnia fall asleep faster. It compares the inhaled melatonin to a placebo to see if it improves sleep and is safe.
Macquarie Park, New South WalesAges 55 years+ - NCT06489327Recruiting
Melatonin before surgery for children
This trial tests two different doses of oral melatonin (a natural sleep hormone) given to children before surgery to help them relax. It may help your child feel calmer before their procedure.
Cairo, Cairo GovernorateAges 4–10 - NCT07869030Recruiting
Melatonin for dental implants in lower jaw
This study tests whether applying melatonin around new dental implants in the lower back teeth helps them heal and stay secure. It may improve the success of implants placed right after tooth extraction.
CairoAges 20–50 - NCT07863232Recruiting
Melatonin and nutrition for fibromyalgia pain relief
This study tests whether taking melatonin, a sleep and pain hormone, along with special nutrition supplements, can help reduce fibromyalgia pain. It may offer a new way to manage symptoms.
LarissaAges 18 years+ - NCT07850934Recruiting
Melatonin for high blood pressure in the lungs of newborns
This trial tests whether giving melatonin to full-term newborns with high blood pressure in their lungs (pulmonary hypertension) can help improve their breathing and oxygen levels. It may offer a new treatment option for babies with this condition.
Cairo, AbbassiaAges Any age - NCT06502613Recruiting
Scoliosis and Sleep Cycle in Children
This study looks at how sleep timing (melatonin levels) might be linked to new cases of scoliosis in children. If you have scoliosis and are between 6 and 15, you may help researchers understand this connection.
Wenzhou, ZhejiangAges 6–15 - NCT07743255Enrolling by invitation
Preventing migraines in children with melatonin and propranolol
This study tests whether two common medicines, melatonin and propranolol, can help prevent migraines in children. If your child has frequent, disabling migraines, this treatment might reduce how often they occur and improve daily life.
Multan, Punjab ProvinceAges 5–15 - NCT07737665RecruitingPhase 4
Melatonin for better sleep in IBD patients in remission
This study tests whether melatonin (a natural sleep hormone) can improve sleep quality in people with inflammatory bowel disease (IBD) whose disease is quiet (in remission). If you have IBD and trouble sleeping, you may be able to join.
Bangkok Noi, BangkokAges 18 years+ - NCT07695246Recruiting
Sleep therapy with melatonin for older adults with insomnia
This study tests whether adding a melatonin supplement to a type of talk therapy for insomnia (called CBT-I) helps older adults sleep better. It aims to improve sleep quality and reduce insomnia symptoms.
Hong KongAges 60 years+ - NCT07651514Recruiting
Magnesium and Melatonin for Better Sleep and Leg Cramps
This study tests whether taking daily magnesium and melatonin supplements can help improve sleep quality and reduce nighttime leg cramps in adults. You'll wear a special ring to track your sleep and use a smartphone app to log your experiences.
Palm Beach Gardens, FloridaAges 40–75 - NCT07617922RecruitingPhase 2
Melatonin and solifenacin for ureteral stent discomfort
This study tests whether two medications—melatonin (a sleep aid) and solifenacin (a bladder-control medicine)—can reduce uncomfortable symptoms from a temporary plastic tube (ureteral stent) placed in your urinary system during kidney stone treatment. The goal is to find out if these drugs help you feel better while the stent is in place.
Banī Suwayf, BeniSuefAges 18–60 - NCT07610876Recruiting
Dentin Graft With Melatonin for Tooth Implant Success
This study tests whether a special graft made from your own tooth material, with or without melatonin (an antioxidant), helps new dental implants integrate better into bone after tooth extraction. The goal is to improve how well implants take hold and function.
IsmailiaAges 20 years+ - NCT07553143Recruiting
Melatonin before gallbladder removal surgery
This study tests whether taking melatonin (a natural sleep hormone) before elective gallbladder removal surgery helps patients recover better and feel less pain or discomfort afterward. Melatonin may help reduce stress on the body during surgery.
Dhaka, Dhaka DivisionAges 18–60 - NCT07549295Enrolling by invitationPhase 1
Melatonin to help babies grow better in the womb
This study tests whether melatonin (a natural sleep hormone) can help babies who are not growing well in the womb due to placental blood-flow problems. Researchers will measure if melatonin improves the baby's growth and health before delivery.
Shanghai, Shanghai MunicipalityAges 20–43 - NCT07542756RecruitingPhase 4
Testing Common Sleep Medications for Insomnia
This study compares how well different over-the-counter and prescription sleep medications work for insomnia. Researchers will guide you through trying medications one at a time to find what works best for your sleep problems.
Philadelphia, PennsylvaniaAges 18–80 - NCT07472075RecruitingPhase 2
Melatonin vs placebo for bipolar disorder
This trial tests whether taking melatonin (a natural sleep hormone) helps stabilize mood in people with bipolar disorder compared to a placebo (a pill with no active ingredient). It may help improve sleep and mood stability.
FrederiksbergAges 18–70 - NCT07442162Enrolling by invitationPhase 1/Phase 2
Melatonin for excessive crying in newborns
This trial tests if melatonin can help reduce excessive crying in otherwise healthy newborns. It may offer a safe option for babies who cry for more than 3 hours a day on more than 3 days a week.
Mosul, Nineveh GovernorateAges 2 weeks–4 weeks - NCT07375342Recruiting
Melatonin for calming children after tonsil removal
This trial tests whether giving melatonin before surgery can help children be less agitated and confused when waking up from anesthesia after tonsil removal. If it works, it could make the recovery smoother for both children and parents.
BanhāAges 4–10 - NCT07375693Enrolling by invitationPhase 2
Melatonin for Parkinson's patients on levodopa
This trial tests if adding melatonin can reduce oxidative stress (a kind of cell damage) in people with mild to moderate Parkinson's disease who are already taking levodopa. It aims to see if melatonin helps protect the brain and improve symptoms.
Dhaka, Dhaka DivisionAges 45–85
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Common questions
- Are there clinical trials for melatonin?
- Yes. Clin2 currently lists 64 recruiting melatonin studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a melatonin trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a melatonin trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.