Clinical trials
Mental Health Disorder clinical trials
Below are recruiting mental health disorder clinical trials, each written for real people, not researchers. We’re tracking 509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06222632Enrolling by invitation
MIND diet and forest bathing for heart and mind
This study tests whether a brain-healthy diet (MIND diet) combined with relaxing walks in nature (forest bathing) can help protect your heart and improve your mood. It is for Chinese adults aged 50–75 who have high cholesterol and some anxiety.
Hong KongAges 50–75 - NCT06032377Recruiting
Online therapy for sleep and brain health in older adults
This study tests an online talk therapy program (CBT) to help older adults with both sleep troubles and mild memory or thinking concerns. It's done from home, and aims to improve sleep and brain health.
Ottawa, OntarioAges 60–99 - NCT06047301Recruiting
Pathways: A hope program for advanced lung cancer patients
This study tests a program called 'Pathways' that helps people with advanced lung cancer set personal goals, manage mental health, and improve quality of life. It's for those who are already receiving IV cancer treatment and are feeling some distress.
Lexington, KentuckyAges 18 years+ - NCT05887934Enrolling by invitation
Bone lead levels and mental health in adults
This study looks at whether the amount of lead stored in the body (from old exposures) is linked to brain activity and mental health. It may help researchers understand what kinds of brain/mental health symptoms are related to lead exposure.
Charleston, South CarolinaAges 18–70 - NCT05363397RecruitingPhase 2
Adjunctive TBO-309 added to stroke clot removal treatment safety
This Phase 2 trial studies whether adding TBO-309 to standard emergency treatment for acute ischemic stroke is safe and tolerable. It may help researchers see if the added drug can be given without causing excessive side effects alongside clot-busting and/or clot-removal procedures.
Camperdown, New South WalesAges 18 years+ - NCT05744479RecruitingPhase 4
Metformin to reduce weight gain from antipsychotic medicines
This trial tests whether metformin can help adults with intellectual disability who gained weight from long-term antipsychotic medicines. If you qualify, you may be assigned metformin to improve weight and related health measures.
Toronto, OntarioAges 16–65 - NCT05666726Recruiting
Understanding how the body and mind influence choices
This study looks at how your body's signals and your ability to reflect on them affect the decisions you make. It involves tasks that may include mild stress, pain, food cravings, or brain scans to better understand these processes.
Bethesda, MarylandAges 18–55 - NCT05603000Recruiting
Emotion-focused therapy for parents of anxious or struggling children
This study tests an emotion-focused family therapy program for parents of children (ages 7–15) who are dealing with anxiety, depression, or behavior challenges. It may help families improve how emotions are understood and managed through parent participation and home life support.
Guelph, OntarioAges 7–15 - NCT05526196Recruiting
Study how cannabis and tobacco affect reaction and feelings
This study tests how cannabis and tobacco—used together or separately—affect your thinking speed, how you feel, and body responses. You may help researchers understand these effects under controlled conditions, which could be useful for safer use and treatment decisions.
Toronto, OntarioAges 19–45 - NCT05442957Recruiting
BRIGHT program after head and neck cancer treatment
This trial tests a “renewed image” program (BRIGHT) compared with another option (AC) after you’ve finished treatment for certain head and neck cancers. It may help you with emotional well-being and adjustment after cancer.
Detroit, MichiganAges 18 years+ - NCT05352061Enrolling by invitation
HIV support program for people with mental health and life challenges
This study looks at how an HIV treatment and prevention program can be improved for people who have HIV plus psychosocial challenges, especially when HIV is not well controlled. You may be able to join if your HIV is recent and higher than target, and you fit one of the specific participant groups.
Miami, FloridaAges 18 years+ - NCT05142735Recruiting
NAC for early psychosis risk symptoms
This trial studies whether NAC (a nutrient-like supplement) can reduce symptoms in people who are at high risk for developing psychosis. It may help by testing a safer, non-standard treatment approach for early warning signs.
Toronto, OntarioAges 16–35 - NCT04569448RecruitingPhase 3
Brexpiprazole for bipolar depression that won’t improve
This Phase 3 study tests whether brexpiprazole can help treat bipolar depression that has not responded to previous treatments. It compares the study medicine to a placebo (inactive pill) for people with bipolar I or II depression.
Hamilton, OntarioAges 18–75 - NCT04396873RecruitingPhase 1
PET brain scan study of inflammation markers in neurodegeneration
This Phase 1 study tests a PET scan to measure inflammation-related changes in the brain using a medication called ketoprofen. It may help researchers understand which people with certain brain diseases could benefit from treatments aimed at inflammation.
Bethesda, MarylandAges 18–99 - NCT04325958Recruiting
Test how cannabis affects driving in different age groups
This study looks at how smoked cannabis changes driving performance when compared across two age groups. It may help researchers understand safety risks and differences by age.
Toronto, OntarioAges 19–45 - NCT03911726Recruiting
Brain imaging study of antipsychotic effects in schizophrenia
This study uses PET and MRI scans to see how antipsychotic medications affect the brain's dopamine system in people with schizophrenia, compared to healthy individuals. It may help understand if these medications cause changes that lead to worsening symptoms over time.
Mannheim, Baden-WurttembergAges 18–65 - NCT03388606Recruiting
Studying adolescent depression and how to treat it
This study looks closely at how depression shows up in teens and tests approaches to treatment. It may help teens and families better understand depression and get access to structured care as part of research.
Los Angeles, CaliforniaAges 11–25 - NCT02543983RecruitingPhase 2
Brain scan and ketamine study for suicidal thoughts
This trial studies how ketamine affects the brain in people dealing with suicidal thoughts or an active suicide crisis. It uses questionnaires, consent testing, and brain imaging to look for biological changes that may relate to symptom improvement.
Bethesda, MarylandAges 18–70 - NCT02531893Recruiting
Therapy for youth with severe, frequent irritability
This study tests whether two structured therapies can reduce severe irritability and angry reactions in children and teens. It focuses on youth who have had long-lasting, frequent outbursts and trouble responding to negative emotions.
Bethesda, MarylandAges 8–17 - NCT01434368Recruiting
Understanding brain and hormone changes during puberty
This study follows children and young adults through puberty to understand how hormones and brain development change together using MRI scans and other tests. If you or your child are healthy and fall into one of the study's age ranges, this research could help explain how puberty affects the brain.
Bethesda, MarylandAges 7–35 - NCT01087281Recruiting
Testing how brain “top-down” attention helps visual processing
This study looks at how signals from the brain’s thinking/attention systems affect how we process what we see. It may help researchers understand brain attention after stroke or other focal brain injuries, and compare with healthy volunteers.
Bethesda, MarylandAges 18–100 - NCT01266577Recruiting
MRI study measuring brain and muscle chemical levels
This study uses MRI techniques to measure natural chemical “metabolites” in the brain and muscle. You may be able to join if you’re generally healthy and can safely complete a long MRI scan.
Bethesda, MarylandAges 18–65 - NCT00109174Recruiting
Brain chemical scan for healthy participants
This study uses a special MRI scan to measure natural brain chemicals. It helps researchers understand how the brain works in healthy people, which may inform future treatments.
Bethesda, MarylandAges 18–65 - NCT06631729Recruiting
Interoceptive exposure app for binge eating disorders
This study tests a smartphone app that helps you notice and cope with body signals linked to binge eating. It is for adults with binge eating disorder or bulimia nervosa who want to try a new digital treatment.
Minneapolis, MinnesotaAges 18–64
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Common questions
- Are there clinical trials for mental health disorder?
- Yes. Clin2 currently lists 509 recruiting mental health disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mental health disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mental health disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.