Clinical trials
Mental Health Impairment clinical trials
Below are recruiting mental health impairment clinical trials, each written for real people, not researchers. We’re tracking 182 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT00018057RecruitingPhase 2
Brain study of pediatric anxiety disorders
This study looks at how the brain works in children and adults with anxiety disorders. It uses brain scans (fMRI) and other safe tests to understand anxiety better.
Bethesda, MarylandAges 8–65 - NCT05012072Recruiting
Lifestyle coaching to lower pregnancy stress and risk
This study tests a lifestyle coaching program to help reduce stress and improve emotional wellbeing during pregnancy. It may help lower risks for the baby by supporting healthier daily routines and mental health.
Webster, TexasAges 18–45 - NCT05142735Recruiting
NAC for early psychosis risk symptoms
This trial studies whether NAC (a nutrient-like supplement) can reduce symptoms in people who are at high risk for developing psychosis. It may help by testing a safer, non-standard treatment approach for early warning signs.
Toronto, OntarioAges 16–35 - NCT05153382Recruiting
Dialectical behavior therapy for youth at bipolar risk
This trial tests whether a structured therapy called dialectical behavior therapy (DBT) helps young people with bipolar disorder or at risk for it, especially with self-harm or risky behaviors. It may help by teaching coping skills and improving safety and emotional control.
Toronto, OntarioAges 13–23 - NCT05363397RecruitingPhase 2
Adjunctive TBO-309 added to stroke clot removal treatment safety
This Phase 2 trial studies whether adding TBO-309 to standard emergency treatment for acute ischemic stroke is safe and tolerable. It may help researchers see if the added drug can be given without causing excessive side effects alongside clot-busting and/or clot-removal procedures.
Camperdown, New South WalesAges 18 years+ - NCT05497115Recruiting
Care model to improve access to mental health after trauma
This trial tests a practical care plan to help people get mental health support after a traumatic injury, especially if screening suggests risk for PTSD or depression. It may help you connect faster to the right kind of treatment after your injury.
Washington, VirginiaAges 16 years+ - NCT05583747Recruiting
Brain stimulation therapy with guidance for treatment-resistant depression
This study tests a type of brain stimulation (guided iTBS) to improve depression when standard antidepressant treatments haven’t helped. It also checks that the treatment is safe for people who can meet the study and scan safety requirements.
Toronto, OntarioAges 18–65 - NCT05608434RecruitingPhase 1/Phase 2
VR training for improving attention in kids with ADHD
This study tests a virtual reality (VR) program meant to strengthen attention skills in children with ADHD. It compares different VR-based training options and looks at whether kids improve on attention-related thinking skills after the sessions.
Bethesda, MarylandAges 8–16 - NCT05744479RecruitingPhase 4
Metformin to reduce weight gain from antipsychotic medicines
This trial tests whether metformin can help adults with intellectual disability who gained weight from long-term antipsychotic medicines. If you qualify, you may be assigned metformin to improve weight and related health measures.
Toronto, OntarioAges 16–65 - NCT05748990Recruiting
Brain insulin differences in schizophrenia and thinking
This study tests whether unusual insulin action in the brain is linked to thinking problems and body/metabolic issues in schizophrenia. It may help researchers understand the cause and identify targets for future treatments.
Toronto, OntarioAges 17–45 - NCT05973110Recruiting
Virtual reality training to improve thinking in psychosis
This trial tests whether a virtual reality program can help people living with psychosis improve thinking and daily functioning. It may help if your symptoms are currently stable and you can safely use the VR equipment.
Ottawa, OntarioAges 18–60 - NCT06032377Recruiting
Online therapy for sleep and brain health in older adults
This study tests an online talk therapy program (CBT) to help older adults with both sleep troubles and mild memory or thinking concerns. It's done from home, and aims to improve sleep and brain health.
Ottawa, OntarioAges 60–99 - NCT06037954Recruiting
Mental health support for older adults with cancer
This study offers mental health care for older adults (65+) with breast, colorectal, lung, or prostate cancer who are getting treatment or recently finished. It aims to help people who are also feeling depressed.
New York, New YorkAges 65 years+ - NCT06047301Recruiting
Pathways: A hope program for advanced lung cancer patients
This study tests a program called 'Pathways' that helps people with advanced lung cancer set personal goals, manage mental health, and improve quality of life. It's for those who are already receiving IV cancer treatment and are feeling some distress.
Lexington, KentuckyAges 18 years+ - NCT06104774Recruiting
Family tai chi after lung surgery for better breathing
This study tests if doing tai chi with your family can help your lungs work better and improve your mood after a thoracoscopic lung surgery. You would practice tai chi exercises and the researchers will check your breathing and mental health.
Taichung, North Dist.Ages 18 years+ - NCT06251635Recruiting
Antipsychotics and brain insulin in women
This study looks at how a common antipsychotic medication (olanzapine) affects how the brain uses insulin in young women. It aims to understand weight gain and metabolic changes linked to these drugs.
Toronto, OntarioAges 18–35 - NCT06350201Recruiting
Online CBT Based on Symptom Groups
This study uses a computer program to group symptoms and then offers an online cognitive behavioral therapy (CBT) program. It aims to help people who feel depressed or anxious by tailoring treatment based on their specific symptom patterns.
WuhanAges 18–64 - NCT06370988Recruiting
Theta-burst stimulation for bipolar depression
This study tests a type of brain stimulation (theta-burst TMS) to see if it helps improve depression in people with bipolar disorder. It might be a good option if you have tried medication but still feel depressed.
Toronto, OntarioAges 18–65 - NCT06373484Recruiting
Matching treatment for kids with disruptive behavior and their parents
This study aims to find the best treatment approach for children with disruptive behavior by matching them to either group or individual therapy. It could help if your child struggles with behavior like defiance or conduct issues, and you're willing to participate in treatment.
Toronto, OntarioAges 6–12 - NCT06417437RecruitingPhase 4
Brain-computer interface test for depression
This trial tests a non-invasive brain-computer interface (BCI) to help people with depression. It may be a good fit for teenagers and adults who are right-handed, Han Chinese, and have moderate to severe depression without other major health problems.
Shanghai, Shanghai MunicipalityAges 12 years+ - NCT06456307Recruiting
Stepped care for mood and anxiety during pregnancy
This study tests a step-by-step approach to help pregnant women who are feeling anxious or down. If you are at least 28 weeks pregnant and feeling stressed, worried, or sad, the study will offer you support and check on how you are doing.
NairobiAges 14 years+ - NCT06462196Recruiting
Study of Depression, Bipolar Disorder & Suicide Risk
This study looks at how depression, bipolar disorder, and suicide risk naturally change over time. It aims to better understand these conditions so doctors can improve treatments.
Bethesda, MarylandAges 18–120 - NCT06493825Recruiting
Mindfulness app for kids with severe tinnitus or misophonia
This trial tests whether a virtual reality mindfulness app can help children aged 10–18 with severe tinnitus or misophonia feel better mentally. It compares the mindfulness app to a placebo (sham) version.
Aurora, ColoradoAges 10–18 - NCT06497920Recruiting
Brain stimulation for motor skills in autistic adults
This trial tests whether a type of brain stimulation called rTMS can improve motor skills (like coordination and movement) in autistic adults. If you have autism and notice challenges with motor function, this study may help.
Toronto, OntarioAges 18–40
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Common questions
- Are there clinical trials for mental health impairment?
- Yes. Clin2 currently lists 182 recruiting mental health impairment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mental health impairment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mental health impairment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.