Clinical trials
Metastasis clinical trials
Below are recruiting metastasis clinical trials, each written for real people, not researchers. We’re tracking 342 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06358222Recruiting
Lung cancer trial testing blood test and PET scan for spread
This trial studies if a blood test that looks for tumor DNA combined with a PET-CT scan can better predict if lung cancer has spread to lymph nodes. It may help guide treatment decisions for people with non-small cell lung cancer that hasn't been treated yet.
ShanghaiAges 18–75 - NCT06362369RecruitingPhase 1/Phase 2
Oral 7HP349 with immunotherapy for advanced solid tumors
This trial tests an experimental oral drug (7HP349) combined with two immunotherapy drugs (ipilimumab and nivolumab) for people with advanced solid tumors. It aims to see if the combination is safe and effective in shrinking tumors.
Aurora, ColoradoAges 18 years+ - NCT06374459RecruitingPhase 1/Phase 2
Zunsemetinib and capecitabine for breast cancer with bone spread
This trial tests a new drug called zunsemetinib combined with the chemotherapy capecitabine for people with hormone receptor-positive, HER2-negative breast cancer that has spread to the bones. The goal is to see if this combination can better control the cancer.
Westwood, KansasAges 18 years+ - NCT06383780RecruitingPhase 3
Tislelizumab plus chemo for nasopharyngeal cancer with bone spread
This trial tests a combination of the immunotherapy drug tislelizumab with chemotherapy for people whose nasopharyngeal cancer has spread to the bones. It may be an option if you have not had prior treatment for advanced disease.
Guangzhou, GuangdongAges 18 years+ - NCT06389786Recruiting
Using a new PET scan to find cancer spread before prostate surgery
This trial tests a special PET/MRI scan that may help doctors see if prostate cancer has spread to nearby lymph nodes before surgery. It could help guide treatment decisions for men with high-risk prostate cancer.
Jacksonville, FloridaAges 30–85 - NCT06399926Recruiting
Pemetrexed via Ommaya for lung cancer in brain lining
This study tests whether a drug called pemetrexed, given directly into the fluid around your brain through a small implanted device, is safe and effective for treating lung cancer that has spread to the lining of the brain. It is for people whose cancer has a specific genetic change (EGFR, ALK, or ROS1) and who have already tried standard targeted pills that no longer control their disease.
Changsha, HunanAges 18 years+ - NCT06400550Recruiting
Melanoma metabolism and spread risk study
This study looks at how the body's metabolism might affect the spread of melanoma. Researchers want to see if certain metabolic traits in people with melanoma are linked to a higher risk of the cancer spreading.
Dallas, TexasAges 18 years+ - NCT06462495RecruitingEarly Phase 1
Comparing two PSMA PET/CT scans for prostate cancer
This trial compares two types of PET/CT scans (using different radioactive tracers) to see which is better at finding prostate cancer, tracking its return, or spotting spread. It's for people with prostate cancer or those being checked for recurrence after treatment.
Hefei, AnhuiAges 18–90 - NCT06462508RecruitingEarly Phase 1
Comparing two PET scans for prostate cancer detection
This trial compares two types of PET scans—one using a new tracer called [18F]F-PSMA-N5 and another using an existing tracer called [68Ga]Ga-PSMA-11—to see which is better at finding prostate cancer, including early signs of recurrence. If you have or are suspected of having prostate cancer, this study may help determine how advanced the disease is.
Hefei, AnhuiAges 18–90 - NCT06462963Recruiting
Single vs multiple radiation doses for cancer spread
This trial compares a single, strong dose of radiation to multiple smaller doses for treating cancer that has spread to a few spots. It aims to see which approach causes fewer side effects.
AalstAges Any age - NCT06500481RecruitingPhase 3
Proton vs standard radiation for cancer spread to brain/spine lining
This trial compares a newer type of radiation (proton therapy) to standard radiation for people whose breast or lung cancer has spread to the lining of the brain and spinal cord. It aims to see if proton therapy can better control the disease while causing fewer side effects.
Phoenix, ArizonaAges 18 years+ - NCT06501391RecruitingPhase 2
Brain radiation plus chemo-immunotherapy for untreated NSCLC with stable brain metastases
This trial tests whether combining brain radiation with chemotherapy and immunotherapy can help people with advanced lung cancer that has spread to the brain but has not yet been treated. It is for those whose tumors do not have certain gene mutations (EGFR, ALK, ROS1).
ShanghaiAges 18 years+ - NCT06501378RecruitingPhase 2
Brain radiation plus chemotherapy and immunotherapy for lung cancer brain metastases
This trial tests a combination of radiation to the brain plus chemotherapy and immunotherapy (anti-PD-1/PD-L1) for people with newly diagnosed non-small cell lung cancer that has spread to the brain. It is for those whose tumors do not have common driver mutations and whose brain metastases are causing symptoms.
ShanghaiAges 18 years+ - NCT06504147RecruitingPhase 2
Radspherin for ovarian cancer with peritoneal spread
This trial tests a radioactive treatment called Radspherin given during surgery for advanced ovarian cancer that has spread to the lining of the abdomen. It is for people whose tumors are HR proficient (a specific genetic type) and who have already had chemotherapy before surgery.
Tampa, FloridaAges 18 years+ - NCT06527027Recruiting
New ways to assess lymph nodes in cancer patients
This trial compares three methods (LN-RADS, RECIST 1.1, and Node-RADS) to see which best evaluates lymph nodes in people with cancer. It may help doctors make more accurate decisions about your lymph nodes using CT or MRI scans.
KrakowAges 18 years+ - NCT06532539RecruitingPhase 2
Cadonilimab with radiation for recurrent endometrial cancer
This trial tests a combined treatment of the immunotherapy drug cadonilimab plus radiation and chemotherapy for endometrial cancer that has come back or spread to only a few places. The goal is to see if this combination can help control the cancer better.
Jinan, ShandongAges 18–80 - NCT06536725Recruiting
Matching chemo to prostate cancer spread to internal organs
This study is testing a new way to match chemotherapy drugs to your specific prostate cancer that has spread to internal organs. Doctors will grow a tiny 3D model of your tumor (organoid) in the lab and test which drugs work best for you.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06538896RecruitingPhase 2
Tislelizumab and nab-paclitaxel for advanced triple-negative breast cancer with bone spread
This trial tests a combination of two drugs, tislelizumab (an immunotherapy) and nab-paclitaxel (a chemotherapy), as the first treatment for advanced triple-negative breast cancer that has spread to the bones. It aims to see if this combination can help shrink or control the cancer.
Hangzhou, ZhejiangAges 18–70 - NCT06540443RecruitingPhase 1
Enhanced MRI for staging head and neck cancer
This trial tests a new imaging agent (MPB-2043) that may help doctors see cancer spread to lymph nodes more clearly during an MRI scan. It is for people with head and neck cancer who are planning to have lymph node surgery.
TaipeiAges 20 years+ - NCT06567353Recruiting
Heat-based immunotherapy for breast cancer liver metastases
This trial tests a new treatment that uses heat to target liver tumors and boost the immune system. It is for women with breast cancer that has spread to the liver who cannot have or do not want surgery.
ShanghaiAges 18–75 - NCT06598046RecruitingPhase 2
Utidelone and Capecitabine for triple-negative breast cancer brain metastases
This trial tests a combination of two chemotherapy drugs (Utidelone and Capecitabine) for people with triple-negative breast cancer that has spread to the brain. The goal is to see if the combination can shrink or control the brain tumors.
Zhengzhou, HenanAges 18 years+ - NCT06619002Recruiting
Using video to make uterine cancer surgery safer
This study is collecting videos from a type of minimally invasive surgery called sentinel lymph node dissection for endometrial or cervical cancer. The goal is to use deep learning (a type of artificial intelligence) to help surgeons identify important structures and any spread of cancer during the procedure, making the surgery safer and more effective.
RomaAges 18–99 - NCT06621823Recruiting
Robotic ultrasound to check lymph nodes during gynecologic cancer surgery
This trial tests a new robotic ultrasound tool to see if it can better find cancer in lymph nodes during surgery. It may help doctors decide exactly which nodes to remove, avoiding unnecessary surgery.
RomaAges 18–99 - NCT06623266Recruiting
Observation vs. neck surgery for early mouth cancer
This study compares two approaches for early-stage mouth cancer: careful observation of the neck versus a preventive surgery to remove neck lymph nodes. The goal is to see which strategy works better to prevent cancer from spreading.
ShanghaiAges 18–75
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Common questions
- Are there clinical trials for metastasis?
- Yes. Clin2 currently lists 342 recruiting metastasis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metastasis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metastasis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.