Clinical trials
Brain Metastasis clinical trials
Below are recruiting brain metastasis clinical trials, each written for real people, not researchers. We’re tracking 45 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06839560RecruitingPhase 2
Immunotherapy plus chemotherapy and radiation for advanced breast cancer with brain metastases
This trial tests a combination of a PD-L1 inhibitor with a low-dose chemotherapy regimen and either immediate or delayed radiation therapy for people with HER2-negative breast cancer that has spread to the brain. The goal is to see if this approach helps shrink brain tumors and improve outcomes.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06839547Recruiting
Testing a new drug with radiation for advanced breast cancer brain tumors
This study looks at how well a new anti-tumor drug works when given along with radiation therapy for people whose advanced breast cancer has spread to the brain. It may help the radiation work better and control the cancer longer.
BeijingAges 18 years+ - NCT05554302RecruitingPhase 2
PET scan study for brain metastases after surgery
This trial studies how well a special PET scan tracer (18F-fluciclovine) shows amino-acid changes in brain metastases after they are surgically removed. It may help improve how doctors detect and understand brain metastases and guide follow-up treatment like targeted radiation (SRS).
Miami, FloridaAges 18 years+ - NCT06330870Recruiting
How breast cancer spreads to the brain
This study looks at how breast cancer spreads to the brain in people who had surgery to remove brain tumors. It helps doctors understand why some women get brain metastases.
SeoulAges Any age - NCT04197297RecruitingPhase 2
Brain scan tests for biomarkers in people with brain metastases
This trial studies brain scan findings to see if specific imaging markers can help understand or predict outcomes in people with brain metastases. It may help researchers improve how brain metastases are evaluated before radiation treatment.
Toronto, OntarioAges 18 years+ - NCT02504788Recruiting
Protect the brain’s memory area during whole-brain radiation
This study tests whether avoiding the hippocampus (a part of the brain important for memory) during whole-brain radiotherapy can slow down thinking and memory decline. It may help some people preserve neurocognitive function while still treating brain metastases.
TaoyuanAges 18–84 - NCT07355348Recruiting
Cognitive support program for brain metastases
This study is testing a program to provide step-by-step cognitive support for adults whose cancer has spread to the brain. It aims to help people think more clearly and manage any memory or attention problems.
Toronto, OntarioAges 18 years+ - NCT07655583Recruiting
Skipping radiation after brain surgery
This study is for people with melanoma or lung cancer that has spread to the brain and who have had surgery to remove the brain tumor. It looks at whether it is safe to skip the usual radiation treatment after surgery, while taking a targeted drug therapy that is known to be effective in the brain.
Houston, TexasAges 18 years+ - NCT06582940RecruitingPhase 2
MRI-guided radiation for lung cancer with brain metastases
This trial tests a new way to deliver radiation to brain metastases from non-small cell lung cancer, using MRI scans to guide the treatment and reduce the area exposed. The goal is to see if this approach is safe and effective while possibly lowering side effects.
Guangzhou, GuangdongAges 18–75 - NCT06727032Enrolling by invitation
Ai detection of brain metastases on MRI
This trial tests an artificial intelligence tool that automatically spots cancer spread to the brain on MRI scans. It may help doctors find brain metastases faster and more accurately for people with cancer outside the brain.
AmsterdamAges 18 years+ - NCT05868928Recruiting
MRI study of brain metastasis relapse after focused radiation
This study looks at MRI scan patterns to estimate the risk of brain metastases coming back after stereotactic radiosurgery (such as Gamma Knife or CyberKnife). It mainly helps by finding imaging clues that can guide follow-up after treatment.
SeoulAges 18 years+ - NCT06055790RecruitingPhase 2
PET scan to find brain tumors from other cancers
This study tests a special PET/CT scan that uses a tracer called 18F-fluciclovine to find brain tumors that have spread from other cancers. It may help doctors see if this scan can better identify these tumors before treatment.
Tucson, ArizonaAges 18–99 - NCT06933199Recruiting
Focused radiation before brain tumor surgery
This study tests giving a single, precise dose of radiation to a brain metastasis just before surgery, to see if it helps control the tumor better without extra side effects. It’s for people who are already planning surgery for a medium-to-large brain tumor that started from another cancer.
Ostrava, Moravian-Silesian RegionAges 18 years+ - NCT06048094RecruitingPhase 1
PET scan study for brain metastases treated with radiosurgery
This trial tests a special PET scan (18F-fluciclovine) to see how well it shows brain metastases after stereotactic radiosurgery (a precise form of radiation). It may help doctors better understand treatment effects.
Miami, FloridaAges 18 years+ - NCT05689619Recruiting
Silibinin after one brain metastasis surgery for lung or breast cancer
This trial studies silibinin, a natural substance, to help prevent brain metastasis from coming back after surgery. It is for people with lung (NSCLC) or breast cancer who have exactly one small brain metastasis that is fully removed and has a specific lab marker in the brain tissue.
GenovaAges 18–70 - NCT06315010RecruitingPhase 2
Repotrectinib for ROS1-positive lung cancer with brain spread
This clinical trial tests a new targeted therapy pill (repotrectinib) for people with ROS1-positive lung cancer that has spread to the brain. The pill is designed to enter the brain and attack cancer cells that other targeted treatments may not reach well.
GrazAges 18 years+ - NCT06159335RecruitingPhase 3
PET/MR scan for brain metastasis imaging
This trial uses a special PET/MR scan with a radioactive tracer to help tell the difference between tumor regrowth and changes from radiation treatment in people with brain metastases. It may help doctors make better treatment decisions.
Madison, WisconsinAges 18 years+ - NCT06501391RecruitingPhase 2
Brain radiation plus chemo-immunotherapy for untreated NSCLC with stable brain metastases
This trial tests whether combining brain radiation with chemotherapy and immunotherapy can help people with advanced lung cancer that has spread to the brain but has not yet been treated. It is for those whose tumors do not have certain gene mutations (EGFR, ALK, ROS1).
ShanghaiAges 18 years+ - NCT07623577RecruitingPhase 2
Sac-TMT and Bevacizumab for Triple-Negative Breast Cancer Brain Tumors
This trial tests a combination of two drugs (Sac-TMT and bevacizumab) to treat triple-negative breast cancer that has spread to the brain. Triple-negative means the cancer cells lack three common markers, making it harder to treat with standard therapies.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06026735Recruiting
Lung cancer with brain spread: a surgical study
This trial looks at people with non-small cell lung cancer that has spread to the brain or the membranes around the brain. It aims to learn more about patients who are already scheduled for brain surgery, such as removing a tumor or placing a drain.
TaipeiAges 20–90 - NCT06418594RecruitingPhase 2
Drug combo for HER2-negative breast cancer brain metastasis
This trial tests a combination of two drugs (adebrelimab and apatinib) plus chemotherapy for women with HER2-negative breast cancer that has spread to the brain. It aims to see if this treatment can help shrink or control brain tumors.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06718933RecruitingPhase 1/Phase 2
Study of a drug combination for breast cancer that spread to the brain
This trial tests whether a combination of three drugs (SHR-A1811, pyrotinib, and bevacizumab) can help people with advanced breast cancer that has spread to the brain. It aims to shrink brain tumors and stop them from growing.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06970639RecruitingPhase 3
Study comparing new targeted drug plus chemo vs osimertinib for lung cancer with brain tumors
This trial tests a new targeted therapy called furmonertinib combined with chemotherapy against the current standard osimertinib for people with a specific type of non-small cell lung cancer (NSCLC) that has spread to the brain. It aims to find a better treatment option for patients whose cancer cells have a common EGFR mutation.
Guangdong, GuangzhouAges 18 years+ - NCT04833335Recruiting
MRI scans to tell tumor spread from radiation injury
This trial studies how a special MRI can help doctors tell whether brain lesions after Gamma Knife treatment are growing tumors or radiation injury. It may help you avoid unnecessary treatment if the findings suggest radionecrosis instead of progression.
ParisAges 18 years+
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Common questions
- Are there clinical trials for brain metastasis?
- Yes. Clin2 currently lists 45 recruiting brain metastasis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain metastasis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain metastasis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.