Clinical trials
Microbiome clinical trials
Below are recruiting microbiome clinical trials, each written for real people, not researchers. We’re tracking 346 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06560554Enrolling by invitation
Fermented diet for long COVID microbiome health
This study tests whether eating fermented foods (like yogurt, kimchi, or sauerkraut) can improve gut health and ease symptoms in people with long COVID. You'll log your food on your phone and follow a fermented diet for a period of time.
Rochester, MinnesotaAges 18 years+ - NCT06566898Recruiting
Tracking antibiotic resistance in pneumonia patients
This study uses advanced genetic testing to monitor antibiotic-resistant bacteria in people with pneumonia. It aims to understand how resistance develops and improve treatment choices.
Shanghai, Shanghai MunicipalityAges Any age - NCT06536881Recruiting
Diet and gut health during breast cancer chemo
This study looks at how changing your diet during chemotherapy affects side effects and your body's energy use. It involves providing stool samples to study gut bacteria.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06538415Recruiting
Can peas and beans improve your skin health?
This study tests whether adding more peas, beans, and lentils (polyphenol-rich pulses) to your daily diet can improve your skin health by changing the natural bacteria living on your skin.
Gainesville, FloridaAges 45–65 - NCT06519162Recruiting
Liver-gut link study for liver disease patients and their families
This study looks at how gut bacteria differ in people with specific liver diseases and their household contacts. It may help researchers understand the connection between the liver and gut.
Daejeon, Jung-guAges 19 years+ - NCT06504160RecruitingPhase 1
Testing a bacteria cream for eczema (TIME-2)
This study tests whether a cream made from a friendly skin bacteria (Staphylococcus hominis) can help treat eczema. Eligible participants will apply the cream to eczema patches on their arms, legs, or trunk for several weeks.
San Diego, CaliforniaAges 6 years+ - NCT06464952Recruiting
Prebiotics for PTSD and cirrhosis
This trial tests if a prebiotic supplement can improve gut health and PTSD symptoms in people with cirrhosis and PTSD. It aims to see if changing the gut microbiome can help both conditions.
Richmond, VirginiaAges 18 years+ - NCT06466434Recruiting
Prebiotic diet to boost immunotherapy for melanoma
This trial tests whether a special prebiotic diet can help your body's bacteria (microbiome) better respond to standard immunotherapy for advanced melanoma that cannot be removed by surgery. If you are starting your first immunotherapy, you may be able to join.
Houston, TexasAges 18 years+ - NCT06453720Recruiting
Predicting Crohn's treatment success with gut bacteria
This study analyzes your gut bacteria to see if it can predict how well you will respond to Crohn's disease treatments. If you are having a colonoscopy for routine care, you may be eligible.
Vancouver, British ColumbiaAges 19–80 - NCT06433115Recruiting
Lean beef and your heart and gut health trial
This study tests how eating lean beef for 4 weeks affects your heart health and the bacteria in your gut. If you qualify, you'll be asked to follow a consistent diet and activity routine during the study.
Columbia, MissouriAges 18–45 - NCT06433310RecruitingPhase 4
A dietary supplement's effect on gut fungi in healthy adults
This study tests whether a dietary supplement (L-phenylalanine) can affect the natural balance of fungi in the gut. Healthy volunteers take the supplement for a short time, and researchers check how it changes their gut fungi.
New York, New YorkAges 18 years+ - NCT06406751Enrolling by invitation
MI Paste and mouth bacteria in older denture wearers
This study tests whether a special paste (MI Paste) used for several months can change the natural bacteria in the mouth of older adults who wear dentures. It may help keep your mouth healthier.
Iowa City, IowaAges 65–105 - NCT06381882Enrolling by invitation
Human microbiome study after pancreatic surgery
This study looks at how tiny organisms in your gut (the microbiome) affect recovery after surgery for pancreatic cancer or related growths. It may help doctors understand how to improve outcomes for future patients.
NieuwegeinAges 18 years+ - NCT06361524Enrolling by invitation
Gut bacteria study in chronic heart failure
This study looks at the bacteria in your gut (your 'gut microbiome') and how it relates to chronic heart failure. It may help doctors understand why some people with heart failure do better than others and could lead to better treatments in the future.
Stanford, CaliforniaAges 18–75 - NCT06359808Recruiting
Sleep Problems in Ulcerative Colitis Patients
This study looks at sleep problems in people with ulcerative colitis (a type of inflammatory bowel disease). It aims to understand how sleep affects your condition and may help find better ways to manage both.
Xi'an, ShaanxiAges 18–65 - NCT06349590RecruitingPhase 1/Phase 2
Diet before colon cancer surgery to reduce recurrence
This trial tests whether a specific diet before colon cancer surgery can change the bacteria in your gut to help prevent the cancer from coming back or spreading. Patients who are eligible will follow the diet for a short time before their operation.
Chicago, IllinoisAges 18 years+ - NCT06329544Recruiting
Study of a high-fructose diet and gut health
This trial tests how a high-fructose diet affects your gut bacteria and overall metabolic health. It is for people who already know they don't absorb fructose well (fructose malabsorbers) and want to understand how this sugar impacts their body.
New York, New YorkAges 25–45 - NCT06291571Enrolling by invitation
Gut bacteria and body response in liver disease
This study looks at the bacteria in your gut (microbiome) and how your body responds to liver disease. Researchers want to learn if these factors can help improve care for people with liver problems.
AberdeenAges 18–70 - NCT06252948Recruiting
Gut bacteria study for POEMS and related plasma cell disorders
This study looks at the gut microbiome (the bacteria living in your digestive system) in people with POEMS syndrome, multiple myeloma, MGUS, amyloidosis, and healthy household members. It may help researchers understand how gut health relates to these conditions.
Rochester, MinnesotaAges 18 years+ - NCT06202183Recruiting
Home exercise for gut health in young colorectal cancer patients
This study tests whether a home-based exercise program can improve the health of your gut bacteria during chemotherapy for young-onset colorectal cancer. It aims to help you feel better and potentially improve how well your treatment works.
Boston, MassachusettsAges 18–50 - NCT06177184Recruiting
Donor milk for full-term cesarean-born babies
This study tests whether giving donor breast milk to full-term babies born by C-section can improve their gut health. If your baby was born by C-section and you plan to breastfeed, this trial may be a good fit.
Calgary, AlbertaAges 9 months+ - NCT05852145RecruitingPhase 1/Phase 2
Testing sweet drinks effect on children’s mouth health
This early-stage study looks at how drinking soft drinks with and without sweeteners affects children’s mouths and teeth. It may help researchers understand which types of sweet drinks contribute to more tooth damage.
Mexico City, CuahutemocAges 12–18 - NCT06117930Recruiting
Brain tumor and gut bacteria study
This study looks at how the bacteria in your gut might be linked to brain tumors. Researchers want to collect samples (like stool and tissue) during brain surgery to better understand this connection.
Jacksonville, FloridaAges 18 years+ - NCT06098404Recruiting
Cancer-related thinking and memory changes linked to gut health
This study looks at how gut bacteria might be connected to memory or thinking problems in people with cancer. If you join, you will answer surveys and provide stool samples to help researchers understand this link.
Galveston, TexasAges 18 years+
Hear when a new Microbiome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for microbiome?
- Yes. Clin2 currently lists 346 recruiting microbiome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a microbiome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a microbiome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.