Clinical trials
Microbiota clinical trials
Below are recruiting microbiota clinical trials, each written for real people, not researchers. We’re tracking 408 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06388863Recruiting
Fecal transplant for constipation in Parkinson's disease
This study tests whether a treatment called fecal microbiota transplantation (FMT) can help relieve constipation in people with Parkinson's disease. FMT uses healthy donor stool to improve gut bacteria, which may ease constipation and possibly improve Parkinson's symptoms.
Shanghai, Shanghai MunicipalityAges 40–75 - NCT06403111RecruitingPhase 2
FMT with immunotherapy and chemotherapy for advanced lung cancer
This trial tests a combination of fecal microbiota transplantation (FMT), immunotherapy, and chemotherapy as a first treatment for advanced non-small cell lung cancer that does not have a driver gene mutation. The goal is to see if adding FMT can help the immune system fight the cancer better.
ChangzhouAges 18–80 - NCT06405113RecruitingPhase 2
Fecal transplant, chemo, and immunotherapy for advanced stomach cancer
This trial tests a combination of fecal microbiota transplant (FMT), chemotherapy (SOX), and an immunotherapy drug (Sintilimab) as a first treatment for advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery. The goal is to see if this combination can shrink tumors and improve outcomes.
ChangzhouAges 18–80 - NCT06451588RecruitingPhase 2
Fecal transplant for axial spondyloarthritis
This trial tests whether a fecal microbiota transplant (a procedure that transfers healthy bacteria from a donor into your gut) can help reduce inflammation and improve symptoms of axial spondyloarthritis. It may be an option if your disease is active despite current treatments.
TromsøAges 18–65 - NCT06451913RecruitingPhase 4
Probiotic for gut health during Lyme disease antibiotics
This trial tests if a probiotic (Saccharomyces boulardii) can help maintain healthy gut bacteria while you take antibiotics for the early skin rash of Lyme disease (erythema migrans). You'll take amoxicillin for 14 days, plus either the probiotic or a placebo.
LjubljanaAges 18 years+ - NCT06460805Recruiting
Diet study for active spine arthritis
This study is testing a special liquid diet called Partial Enteral Nutrition (PEN) to see if it can help calm inflammation in people with active axial spondyloarthritis. You would replace some of your regular meals with this diet drink for a period of time.
GlasgowAges 16 years+ - NCT06461208RecruitingPhase 3
Fecal transplant for people with cirrhosis
This trial tests whether transplanting healthy gut bacteria (from donor stool) can improve outcomes in people with cirrhosis. If you have mild to moderate cirrhosis, you may be able to join.
BasildonAges 18 years+ - NCT06479928Recruiting
How environment and gut bacteria affect early life
This study looks at how things in the environment (like diet, pollution, or lifestyle) and the bacteria in a baby's gut affect health early in life. It is for pregnant women who are in their last month of pregnancy and their newborns.
BeijingAges 1 day–2 years - NCT06481020Recruiting
Plant sterols for heart health in overweight adults
This study tests whether plant sterols (natural compounds found in plants) can help improve cholesterol and other heart health markers. If you are overweight and have high LDL cholesterol, you may be able to join this study to see if adding plant sterols to your diet helps.
ValenciaAges 18–80 - NCT06495333Recruiting
Gene and gut bacteria in Hispanic fatty liver patients
This study looks at how a gene variant (PNPLA3) relates to gut bacteria in Hispanic patients with fatty liver disease (MASLD) in Puerto Rico. It aims to understand the connection between your genes, your gut health, and your liver condition.
San JuanAges 21–75 - NCT06527326Recruiting
Gut bacteria and central serous chorioretinopathy study
This study looks at the link between gut bacteria and central serous chorioretinopathy (CSC), a condition where fluid builds up under the retina. It may help us understand why some people get CSC and find better ways to treat it.
Hanzhou, ZhejiangAges Any age - NCT06528041Recruiting
Chicory fiber and gut health study
This study tests whether a natural fiber from chicory root can change and keep changes in your gut bacteria. It may help improve digestion and overall health.
West Lafayette, IndianaAges 18–45 - NCT06539832Recruiting
Gut bacteria and immunity in people with an abnormal blood protein
This study looks at how your gut bacteria (intestinal flora) and immune system relate to a condition called monoclonal gammopathy, where an abnormal protein is found in the blood. The trial will check samples from your blood, plasma, and stool to understand these connections.
Guanzhou, GuangdongAges 45 years+ - NCT06546020Recruiting
Haskap berries for gut and metabolic health
This study tests whether a berry called Haskap can improve your gut health and how that might affect your overall health. Researchers are looking for people with and without certain metabolic risk factors to see who benefits most from adding these berries to their diet.
Bozeman, MontanaAges 35–65 - NCT06551272RecruitingPhase 2
Gut bacteria change to help immunotherapy for liver cancer
This trial tests whether changing the bacteria in your gut (with a probiotic) can help your current immunotherapy work better if your liver cancer has been growing. It's for people with advanced liver cancer who will continue their same immunotherapy despite the cancer progressing.
BobignyAges 18 years+ - NCT06551285Recruiting
Nutrition supplement for PCOS: effects on health and quality of life
This study tests whether a nutritional supplement can improve metabolism, reduce inflammation, and enhance quality of life in women with polycystic ovary syndrome (PCOS). It aims to help manage PCOS symptoms through dietary support.
Valencia, ValenciaAges 18–45 - NCT06560840Recruiting
Diet study for healthy aging in people with HIV
This study tests whether a special diet aimed at improving gut health can help reduce the risk of heart disease in older adults living with HIV. If you are 40 or older, have certain heart risk factors, and are interested in making dietary changes, this study might be a good fit for you.
ShenzhenAges 40 years+ - NCT06562842Recruiting
Exercise, Gut Health, and Type 2 Diabetes Study
This study looks at how exercise affects gut bacteria in people with type 2 diabetes. It may help explain why physical activity improves diabetes control.
TrikalaAges 45–65 - NCT06576622Recruiting
Periodontal disease, bacteria, and miscarriage
This study looks at whether gum disease and oral bacteria are linked to repeated pregnancy loss. If you have had multiple miscarriages, your gum health may play a role.
ToulouseAges Up to 18 years - NCT06585982Recruiting
Synbiotics for MAFLD: gut health and liver fat study
This trial tests whether taking a synbiotic (a mix of helpful bacteria and fiber) can improve insulin levels and reduce inflammation in people with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD). It may help by changing the balance of bacteria in your gut.
Semarang, SemarangAges 25–55 - NCT06604338Recruiting
Genes and gut bacteria in recurrent pregnancy loss
This study looks at genes and gut bacteria in women who have had repeated miscarriages without a known cause. It aims to find possible reasons for these losses and could help improve future care.
Porto Alegre, Rio Grande do SulAges Any age - NCT06615986RecruitingEarly Phase 1
Synbiotic supplement test for gut health
This trial tests a synbiotic supplement made from human milk sugars to see if it can improve gut bacteria balance in healthy adults. You might join if you are 18 to 99, generally healthy, and not taking medications that affect your gut.
Bethesda, MarylandAges 18–99 - NCT06623461RecruitingPhase 2
Fecal transplant with immunotherapy for advanced melanoma
This trial tests if giving a special capsule of donated bacteria (fecal transplant) alongside standard immunotherapy helps shrink tumors in people with advanced melanoma. It aims to see if adding the bacteria can make the immune therapy work better.
Abbotsford British Columbia, British ColumbiaAges 18 years+ - NCT06624865Recruiting
Gut bacteria and small-intestine neuroendocrine tumor study
This study looks at how bacteria in your gut may affect the growth of small-intestine neuroendocrine tumors. If you are having surgery to remove one of these tumors, the research team will collect samples and data to better understand the link between your gut bacteria and the tumor.
Lyon, FranceAges 18 years+
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Common questions
- Are there clinical trials for microbiota?
- Yes. Clin2 currently lists 408 recruiting microbiota studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a microbiota trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a microbiota trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.