Clinical trials
Migraine Headache, With or Without Aura clinical trials
Below are recruiting migraine headache, with or without aura clinical trials, each written for real people, not researchers. We’re tracking 195 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06584409Recruiting
Laser Acupuncture vs Standard for Migraine – Blood Test Study
This trial tests whether laser acupuncture can help migraines by checking two substances in your blood (MMP2 and CGRP). You may be able to join if you have migraines and are not pregnant.
Taichung, TaichangAges 18 years+ - NCT06652724Recruiting
Psychological help for chronic pain in fibromyalgia and migraine
This study looks at how psychological factors and treatments might help with chronic pain in people with fibromyalgia and/or chronic migraine. It compares different groups to understand what works best.
Rome, RMAges 18–50 - NCT06690060Recruiting
Mind-body program for chronic migraine
This study tests whether a mind-body program, done remotely, can help people with chronic migraines reduce headache impact. It is for adults who have migraines at least 5 days a month and are willing to learn relaxation and stress-management techniques.
Boston, MassachusettsAges 18 years+ - NCT06745648Recruiting
Head massage in a head-down position for headache relief
This trial tests a simple, non-drug technique (carotid sinus massage while lying with your head lower than your body) to see if it can relieve headaches. If you have a migraine, tension headache, or mixed headache that started in the last day, you may be able to join.
Trenque Lauquen, Buenos AiresAges 16 years+ - NCT06788977Recruiting
Migraine treatment in pregnancy with a nerve stimulation device
This trial tests if a device that gently stimulates a nerve on your forehead can safely treat migraines during pregnancy. You'll use the device at home and track your headaches via text or email.
Darien, ConnecticutAges 18–44 - NCT06459648Recruiting
Can anti-CGRP antibodies prevent chronic migraine?
This study tests a new treatment (anti-CGRP antibodies) to prevent migraine attacks from becoming chronic. It looks at whether we can predict who will respond best, aiming to find better long-term control for people with frequent or chronic migraine.
Zaragoza, AragonAges 18–65 - NCT07454798Recruiting
Virtual reality neurofeedback for teens with migraine
This study tests whether using virtual reality neurofeedback can help teens with migraine. You would wear a VR headset and learn to control your brain's activity to reduce headache frequency.
Kansas City, MissouriAges 10–16 - NCT07476053Recruiting
How light exposure affects migraine and sleep
This study looks at how office lighting and sleep quality affect migraine. You'll track your headaches and light exposure. The goal is to find ways to improve sleep and reduce migraine attacks.
Tempe, ArizonaAges 18 years+ - NCT07500558Recruiting
Ultrasound-guided nerve block for chronic migraine pain relief
This study tests two power levels of a pulsed radiofrequency treatment aimed at a nerve cluster behind your cheekbone to reduce chronic migraine pain. If you have frequent migraines that haven't responded well to two or more preventive medications, this could be an option for you.
MinyaAges 20–70 - NCT07554664Recruiting
Desk Work, Stress, and Muscle Pain With or Without Migraine
This study looks at how office work, job stress, and muscle tension relate to migraines and neck/shoulder pain in desk workers. Researchers want to understand if certain body changes (called central sensitization) connect these issues, which could lead to better ways to help office workers feel better.
Gaziantep, MerkezAges 18–65 - NCT07373275Enrolling by invitation
Lifestyle Medicine for Teen Migraine
This study tests whether a lifestyle medicine program (like healthy habits and stress management) can help reduce migraine headaches in teenagers. It's for teens who get frequent migraines and are patients at certain MaineHealth clinics.
Scarborough, MaineAges 14–18 - NCT06834022Enrolling by invitation
Comparing acupuncture and brain stimulation for migraine
This study compares two non-drug treatments—acupuncture and a gentle form of brain stimulation (tDCS)—to see which one helps reduce migraine headaches better. It's for people who have at least 4 migraine days per month and have never tried acupuncture before.
Ljubljana, LjubljanaAges 18–65 - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT03511846Enrolling by invitationPhase 1
Pain biomarker study for headache or back nerve pain
This study looks at measurable “pain signals” (biomarkers) in people with certain headache disorders or lumbar nerve pain, and compares them with healthy people. It may help researchers better understand what drives pain and how it can be detected.
Houston, TexasAges 18 years+ - NCT07720765Recruiting
Using eye scans to study brain diseases
This trial uses a type of eye scan (OCT) to look at the retina in people with brain conditions like multiple sclerosis, Alzheimer's, Parkinson's, or migraines. It aims to see if these scans can help doctors learn more about the disease and monitor it over time.
Milan, MilanoAges 18 years+ - NCT04930887RecruitingPhase 2
Numbing injection in the face to ease craniofacial pain
This trial tests whether an injection of a numbing medicine (bupivacaine) guided by an endoscope can reduce craniofacial pain. It may help people with certain headache or facial pain conditions by targeting the pain area more precisely.
Stanford, CaliforniaAges 18–80 - NCT06464367RecruitingEarly Phase 1
Psilocybin study for migraine and healthy volunteers
This study looks at how psilocybin affects the brain in people with migraines and in healthy volunteers. The goal is to understand why it may help with headache disorders.
West Haven, ConnecticutAges 21–70 - NCT05337033RecruitingPhase 2
Testing cannabis for chronic headaches in teens
This trial studies whether cannabis can reduce chronic migraine headaches in adolescents who have not improved with other treatments. It also asks participants to work with psychology and physiotherapy during the study.
Vancouver, British ColumbiaAges 14–17 - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT06016465RecruitingEarly Phase 1
Nerve block plus steroid to prevent migraine return in 72 hours
This trial tests whether adding a steroid pill (dexamethasone) to a nerve block can stop a migraine from coming back within three days. It's for people whose headache got much better after a nerve block.
El Paso, TexasAges 18–85 - NCT06077838Recruiting
RELAXaHEAD app test for migraine relief
This study tests a smartphone app called RELAXaHEAD that teaches relaxation techniques to help people with migraine. If you have 4–29 headache days per month and haven't tried relaxation therapy for headaches recently, this app might help reduce your symptoms.
New York, New YorkAges 16–80 - NCT07347028Recruiting
Trigger point injections for knee osteoarthritis pain
This trial tests whether injecting medication into muscle knots (trigger points) can reduce knee pain in people with knee osteoarthritis. It may be an option if other treatments haven't helped enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT05987592Recruiting
Wellness and brain education for migraine relief
This study tests an 8-week online program that combines brain education and wellness skills to help people with migraine. It aims to reduce headache-related disability and improve quality of life.
Cambridge, MassachusettsAges 18 years+ - NCT05176392Recruiting
Stimulation treatment plus therapy for post-injury headaches
This study tests whether a noninvasive brain stimulation treatment combined with therapy can reduce long-lasting headaches after a mild brain injury. You might be a good candidate if your headaches started after the injury and have continued for months.
San Diego, CaliforniaAges 18–65
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Common questions
- Are there clinical trials for migraine headache, with or without aura?
- Yes. Clin2 currently lists 195 recruiting migraine headache, with or without aura studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine headache, with or without aura trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine headache, with or without aura trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.