Clinical trials
Mild Cognitive Impairment clinical trials
Below are recruiting mild cognitive impairment clinical trials, each written for real people, not researchers. We’re tracking 406 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06722976Enrolling by invitation
Digital health and exercise for staying independent longer
This trial tests a program that combines digital health tools with exercise to help older adults stay active and independent. It may be a good fit if you are 65 or older and can walk or move around without major difficulty.
Covilha, CovilhãAges 60 years+ - NCT06023446Enrolling by invitation
Can eye photos detect early Alzheimer's disease?
This study uses a special camera (OCT) to take pictures of the retina (the back of your eye) to see if it can detect Alzheimer's disease very early. You may be eligible if you are either cognitively normal or have mild cognitive impairment, and have already had a test for Alzheimer's-related brain changes.
Sacramento, CaliforniaAges 50–89 - NCT05457998Enrolling by invitation
Study of Alzheimer’s brain markers using memory testing
This trial looks for signs of Alzheimer’s disease in the brain by using memory and thinking tests, and related study procedures. It may help researchers find better ways to identify Alzheimer’s-related changes earlier.
Providence, Rhode IslandAges 50–80 - NCT04482660Enrolling by invitation
PET brain scan study of tau protein in ALFA volunteers
This study uses a special PET brain scan tracer to measure “tau” protein clumps in the brain. It’s meant to better understand brain changes in people who are already part of the ALFA research program, and may help researchers connect tau levels with memory and thinking.
Barcelona, BarcelonaAges 45 years+ - NCT03687710Enrolling by invitation
Alzheimer’s registry for people with memory concerns or risk
This is a research registry that helps doctors compare how different memory and Alzheimer’s risk groups change over time. It may help researchers learn which people are more likely to develop Alzheimer’s and how to better track early changes.
New York, New YorkAges 18–99 - NCT03370224Enrolling by invitation
Story memory training for older adults
This study tests a memory-skills training approach (the Modified Story Memory Technique) to help older adults with aging-related memory changes. You may be asked to do memory exercises, and some people may also complete an optional brain MRI scan.
East Hanover, New JerseyAges 65 years+ - NCT03089827Enrolling by invitation
Tests how a brain imaging tracer spreads in Alzheimer’s risk
This trial uses a radioactive imaging tracer to see how it moves and settles in the brain in people with risk factors for Alzheimer’s disease. It may help researchers understand which people show tracer patterns linked to Alzheimer’s changes.
Winston-Salem, North CarolinaAges 55 years+ - NCT06088212Recruiting
Heart failure treatment to help thinking and memory
This trial tests whether better managing heart failure after a hospital stay can protect against thinking and memory problems. It is for people who have heart failure and have had some cognitive difficulties.
Hobart, TasmaniaAges 18 years+ - NCT06969066Recruiting
Memory training for insomnia with memory problems
This trial tests memory training for people who have both insomnia and mild memory issues. It aims to see if this training can improve sleep and memory.
BeijingAges 8 years+ - NCT05762796Recruiting
Brain scan and stimulation study for kids with mild concussion
This study tests whether a brain “stimulation” approach, paired with brain imaging (MRI), can help children who still have symptoms after a mild concussion. There is also a comparison group of children without concussion history.
Buffalo, New YorkAges 10–15 - NCT06528379Recruiting
Physical activity to prevent thinking decline in older adults
This study tests whether a physical activity program can help prevent memory loss and disability in older Greek adults who have noticed some decline in their thinking. You can join if you have mild memory concerns but no dementia and are healthy enough to be active.
Pátrai, AchaiaAges 50 years+ - NCT07452939Recruiting
Brain stimulation to help memory after ICU delirium
This study tests if a noninvasive brain stimulation technique called theta burst stimulation can improve thinking and memory problems that can happen after a stay in the ICU with delirium. It may help people who are still having cognitive issues a few months after leaving the hospital.
Gainesville, FloridaAges 50–75 - NCT05592678Recruiting
Study brain and memory test changes in Alzheimer’s or mild issues
This study looks at how well people with Alzheimer’s disease (AD) or mild cognitive impairment (MCI) perform on standardized memory/brain tests. It may help researchers understand changes over time, and whether certain types of brain signals or test results track with the condition.
San Antonio, TexasAges 65–100 - NCT03514524Enrolling by invitation
PET-MRI brain scans for recent injury, stroke, or mild memory changes
This study uses special brain scans to measure proteins and connections in the brain after a recent injury, stroke, or in people with mild memory/behavior changes. The goal is to understand brain changes and how they relate to symptoms, which may help future diagnosis and treatment.
LeuvenAges 18–80 - NCT03860857RecruitingPhase 3
Study biomarkers in memory aging and brain health
This Phase 3 study looks for blood/brain “biomarkers” linked to aging, memory changes, and early brain degeneration. It may help researchers better identify who is at risk and how biology relates to thinking and memory, using brain scans and thinking tests.
Irvine, CaliforniaAges 60 years+ - NCT07547319Recruiting
Accelerated rTMS to improve cognitive function
This study tests whether repeated magnetic pulses to the brain (called rTMS) can help improve thinking and memory in older adults with mild to moderate cognitive decline. The treatment is non-invasive and may help slow cognitive changes.
San Francisco, CaliforniaAges 50–90 - NCT06095297Recruiting
Cognitive rehab for brain fog from long COVID
This study tests a computer-based cognitive training program combined with a gentle nerve stimulation device to see if it can improve brain fog and daily functioning in people with long COVID. If you're struggling with thinking, memory, or concentration after COVID, this might help.
Birmingham, AlabamaAges 18 years+ - NCT04184375Recruiting
Memory training for older adults with bipolar disorder
This study tests whether structured memory and thinking exercises (cognitive stimulation) help older adults with bipolar disorder who have mild to moderate thinking and memory problems. You may be offered guided sessions designed to improve everyday thinking skills while checking safety and fit for the program.
La RochelleAges 65 years+ - NCT06579664Recruiting
Brain stimulation for memory loss from small vessel disease
This trial tests whether a type of non-invasive brain stimulation called intermittent theta burst stimulation can improve memory and thinking in people whose cognitive problems are caused by cerebral small vessel disease (damage to the small blood vessels in the brain). You may qualify if you have mild memory or thinking issues that have lasted at least three months.
BeijingAges 45–80 - NCT07523113Recruiting
Brain Fog Treatment for ME/CFS Using Cognitive Training
This study tests whether a computerized cognitive training program combined with a mild electrical nerve stimulation device (worn on the ear) can help improve thinking and memory problems in people with ME/CFS. The goal is to see if this approach helps with brain fog and daily functioning.
Birmingham, AlabamaAges 18 years+ - NCT04297020Recruiting
Checking brain health in breast cancer survivors
This study looks at differences in brain function in people who have had breast cancer, compared with certain people without that history. It’s testing how brain health changes after breast cancer and relates to mood, thinking, and daily functioning.
Los Angeles, CaliforniaAges 35–65 - NCT06452147Recruiting
Anesthesia and brain health after hip surgery in older adults
This trial is testing different types of anesthesia to see how they affect brain function (memory, thinking) after hip fracture surgery in older adults. It aims to find the safest approach for elderly patients.
Wenzhou, ZhejiangAges 65 years+ - NCT05273125Recruiting
Testing mobility and thinking in people with mild cognitive problems
This study looks at how well people with mild cognitive problems can think and move, using brief learning/thinking tests and a walking task. It may help researchers understand changes early enough to guide future care.
LilleAges 65 years+ - NCT06839079Recruiting
Brain training for trauma survivors with head injury
This study tests a cognitive rehabilitation program for people with traumatic brain injury who have also experienced war, violence, or other trauma. It aims to improve memory and thinking skills using exercises and strategies.
Boston, MassachusettsAges 18–65
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Common questions
- Are there clinical trials for mild cognitive impairment?
- Yes. Clin2 currently lists 406 recruiting mild cognitive impairment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mild cognitive impairment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mild cognitive impairment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Amnestic Mild Cognitive Impairment
- Mild Cognitive Impairment (MCI) Amnestic
- Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
- Mild Cognitive Impairment Due to Alzheimer's Disease
- Cognitive Impairment
- Subjective Cognitive Impairment
- Post-Stroke Cognitive Impairment (PSCI)
- Vascular Cognitive Impairment
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.