Clinical trials
Mild Neurocognitive Disorder clinical trials
Below are recruiting mild neurocognitive disorder clinical trials, each written for real people, not researchers. We’re tracking 33 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05245903Recruiting
Test a supplement and track brain changes with wearable sensors
This study tests whether taking nicotinamide riboside (a form of niacin) affects early memory changes in people with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD). It also uses passive wearable or sensor data (“digital biomarkers”) to measure changes over time.
Belmont, MassachusettsAges 18–89 - NCT06983119Recruiting
Finding early signs of memory loss in Pavia
This study looks for early thinking and memory changes in people 50 and older who haven't been diagnosed with cognitive decline. You'll complete a quick assessment to see if further checkups might help.
Pavia, PaviaAges 18 years+ - NCT07038798Recruiting
Deep rTMS for mild memory problems in older adults
This trial is testing whether a non-invasive brain stimulation technique called deep rTMS can help older adults with mild memory or thinking problems. It aims to see if this treatment can improve cognitive function without major side effects.
Hamilton, OntarioAges 60–90 - NCT07237009Recruiting
Personalized reminiscence therapy for memory loss
This trial tests a digital app that uses personal photos and memories to help people with early memory problems feel less depressed or apathetic. It's designed for seniors who have mild cognitive impairment or early dementia.
AngersAges 60 years+ - NCT07526740Recruiting
Brain Stimulation and Training for Mild Memory Loss
This study tests whether combining brain stimulation (TMS) with cognitive training games can help people with mild cognitive impairment—early memory and thinking problems. The goal is to see if this combination improves thinking abilities and slows cognitive decline.
Charleston, South CarolinaAges 60–85 - NCT06112639Recruiting
Dance-based rehab for chronic brain conditions
This trial tests a dance exercise program for people with multiple sclerosis or early memory loss. It aims to see if dancing can help physical and mental function safely at home.
BresciaAges 18–85 - NCT05561205Recruiting
Brain stimulation to treat persistent apathy
This trial tests a noninvasive brain stimulation treatment (called rTMS) to help people who have had ongoing apathy (lack of motivation/interest) for at least a month. You might benefit if your apathy is persistent, your other symptoms are stable, and you meet the safety and medication rules.
Toronto, OntarioAges Any age - NCT06606353Recruiting
Talk-to-Jo: A digital companion for memory issues
This trial tests a French-speaking digital assistant called Talk-to-Jo for people recently diagnosed with mild to moderate memory or thinking problems and their caregivers. The goal is to see if this tool helps both the person with memory issues and the person caring for them.
Montreal, QuebecAges 65 years+ - NCT05457725Recruiting
Study how aging affects learning to trust and distrust
This study looks at how thinking and learning processes change with age, especially around deciding what to trust. You may be asked to complete computer tasks and brief memory/thinking tests to understand these changes.
Gainesville, FloridaAges 18–100 - NCT05929703Recruiting
Care approach for hospitalized older adults at risk of confusion
This trial tests new ways to help hospitalized older adults (and their family/care partners) stay comfortable and avoid or reduce episodes of acute confusion. It focuses on people who are likely to develop delirium during their hospital stay.
Orange, CaliforniaAges 70 years+ - NCT06143488Recruiting
Clot removal vs. best medicine for mild stroke with large vessel blockage
This trial tests whether removing a blood clot from a large brain artery is better than standard medical care for people who have a mild stroke (NIHSS score 2-5) but still have symptoms like trouble speaking, weakness, or confusion. It is for patients who can be treated within 24 hours of their last known well time.
Wuhu, AnhuiAges 18 years+ - NCT06718140Enrolling by invitationPhase 1
Ultrasound for memory in mild cognitive decline
This study tests if a non-invasive ultrasound treatment can help memory in people with mild cognitive impairment (mNCD) and healthy older adults. It involves MRI scans and focused ultrasound sessions.
Charleston, South CarolinaAges 50–85 - NCT06416514Recruiting
Personalized help for mild behavioral changes
This study tests a personalized program to support people with mild behavioral impairment (changes in mood, motivation or social behavior) and see if it can improve their health. If you are 60 or older and notice these changes, this trial might help you get tailored support.
Fuzhou, FujianAges 60 years+ - NCT05668598Recruiting
Memory check study for older adults with and without dementia
This study creates a practical tool to measure “episodic memory,” which is your ability to recall events from daily life. It includes adults age 70+ with different memory levels, to see how well the tool works for people with dementia and for those without.
LensAges 70 years+ - NCT06780917Recruiting
Online cognitive testing for older adults with depression or memory concerns
This study tests whether an online cognitive assessment platform (Creyos) is valid for older adults with major depression or mild cognitive impairment. Participants will complete brain games or puzzles to see how well the online tool measures thinking skills.
Toronto, OntarioAges 60 years+ - NCT06701630Recruiting
Italian study of daily thinking and memory scales
This study is testing new questionnaires to better understand everyday thinking and memory problems in older adults. It aims to improve how doctors identify and track conditions like mild cognitive impairment and early dementia.
Milan, MichiganAges 60 years+ - NCT06088121Recruiting
TMS with cognitive training for mild Alzheimer's dementia
This study tests a combination of brain stimulation (TMS) and cognitive training to improve memory and thinking in people with mild Alzheimer's. It may help if you are already on a stable dose of a donepezil-type medication and have a confirmed Alzheimer's diagnosis.
Incheon, Bupyeong 6(yuk)-dong, Bupyeong-guAges 60–85 - NCT06597591Recruiting
Virtual reality training to improve self-control in memory loss patients
This study tests whether a virtual reality training game can help improve your ability to stop yourself or control impulses, which can be affected in early memory problems. You will use a VR headset to practice these skills in a safe, fun environment.
NiceAges 60 years+ - NCT06482749Recruiting
Magnetic brain stimulation for better recovery after surgery
This study tests whether magnetic brain stimulation before and after surgery can help older adults with mild memory or thinking problems recover their thinking abilities faster. You would receive either real or sham stimulation for a few days around your surgery.
Beijing, Beijing MunicipalityAges 65 years+ - NCT06375265Recruiting
Sleep improvement program for older surgery patients
This trial tests a digital sleep improvement program for older adults who are about to have knee or hip replacement surgery. It aims to help you sleep better before and after surgery, which may improve your brain health and recovery.
Boston, MassachusettsAges 65 years+ - NCT05943834Recruiting
Voice testing to detect early memory and mood changes
This trial studies whether automated analysis of your voice and speech can help detect early signs of Alzheimer’s disease and mood (affective) problems. It may help identify changes sooner, using voice and questionnaire information from people who are cognitively healthy to very mildly affected.
NiceAges 50–100 - NCT06375213Recruiting
Memory and thinking study for all ages
This study looks at how well people think and remember as they age. It includes healthy volunteers, people with mild memory issues, and those with dementia—both early- and late-onset.
Pathum Wan, BangkokAges 35 years+ - NCT06523296Recruiting
Antibodies and thinking problems in myasthenia or Alzheimer's
This study looks at whether certain antibodies are linked to memory and thinking problems in people with myasthenia gravis or Alzheimer's disease. It involves a one-time use of leftover spinal fluid from a previous diagnostic test.
Nice, Alpes MaritimesAges 18 years+ - NCT04436081RecruitingPhase 2
CBD oil without THC for agitation in Alzheimer’s dementia
This trial studies whether a THC-free CBD oil softgel can reduce agitation in people with Alzheimer’s-related dementia. It compares CBD to a control to see if it improves difficult behaviors and is safe over the study period.
Norfolk, VirginiaAges 50–90
Hear when a new Mild Neurocognitive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for mild neurocognitive disorder?
- Yes. Clin2 currently lists 33 recruiting mild neurocognitive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mild neurocognitive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mild neurocognitive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.