Clinical trials
Musculoskeletal Diseases or Conditions clinical trials
Below are recruiting musculoskeletal diseases or conditions clinical trials, each written for real people, not researchers. We’re tracking 4,021 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04099823Recruiting
MRI study of spinal fluid flow in memory or balance problems
This study uses MRI to look at how spinal fluid moves inside and around the brain. It aims to better understand conditions that can affect thinking, memory, balance, and coordination—such as normal pressure hydrocephalus—or compare with healthy people.
Rochester, MinnesotaAges 18 years+ - NCT04927429Recruiting
MRI study to improve heart imaging
This trial helps develop and fine-tune MRI scans that look at the heart and blood vessels. It may help people with heart-related symptoms or conditions by improving how MRI images are created and interpreted.
Washington D.C., District of ColumbiaAges 18–100 - NCT04888923Recruiting
How environmental exposures affect your health
This study observes how your body responds to environmental exposures or injuries over time. It aims to understand how different factors like genetics or lifestyle affect your health.
Research Triangle Park, North CarolinaAges 18–90 - NCT04927416RecruitingPhase 2
Ga-DOTATATE PET/CT scan in metastatic thyroid cancer
This study tests whether a specific special scan (68-Gallium DOTATATE PET/CT) can help doctors better see where thyroid cancer has spread. It focuses on certain types of thyroid cancer and compares how well the scan images metastases.
Bethesda, MarylandAges 18–98 - NCT04896606RecruitingPhase 1/Phase 2
Matched donor immune therapy for mild to moderate COVID-19
This early-phase study tests immune cells from a matched family donor (made to target the COVID-19 virus) to see if they can help people with mild-to-moderate COVID-19 who are hospitalized and at higher risk for getting sicker. It aims to check safety first and also look for signs of benefit.
Valhalla, New YorkAges 18–65 - NCT04876131RecruitingPhase 4
Single-dose IV antibiotics for children with complicated urinary tract infections
This trial tests whether one dose of intravenous (IV) antibiotics is as effective as the usual multiple-dose course for children with complicated urinary tract infections (UTIs) who need IV treatment in the emergency department. It aims to reduce hospital stays and the need for repeated IV lines.
Adelaide, South AustraliaAges 3 months–18 years - NCT04299828Recruiting
Study of inflammation activity during complex heart surgery
This study measures how active white blood cells and inflammation are during complex heart surgery using a heart-lung machine. It may help doctors better understand what triggers inflammation during surgery and how to improve care.
Boston, MassachusettsAges Any age - NCT04787744RecruitingPhase 2/Phase 3
Test standard prostate cancer treatment with or without targeted spot radiation
This study tests whether adding targeted local treatment (like radiation to a few spots seen on scans) improves outcomes for some people with limited (oligometastatic) prostate cancer. It compares standard systemic therapy alone versus standard therapy plus PET-scan–guided spot treatment.
Long Beach, CaliforniaAges 18 years+ - NCT04799301RecruitingPhase 1
Measure how much sugar you eat using blood and hair samples
This Phase 1 study tests whether “biomarkers” in your blood and hair can accurately measure how much sugar you consume. It may help researchers find better ways to track dietary sugar intake in future nutrition and health studies.
Phoenix, ArizonaAges 18–65 - NCT04781322RecruitingPhase 1
Study drug to reduce LDL cholesterol effects in heavy drinkers
This Phase 1 study tests how safe a cholesterol-lowering antibody (alirocumab) is in people who drink heavily but are not seeking alcohol treatment. It also looks at early drug effects in the body to see how it might change cholesterol-related signals.
Bethesda, MarylandAges 21–65 - NCT04772170Recruiting
Study wearable and symptom monitoring during respiratory virus challenges
This observational study looks for digital health patterns during studies where people are intentionally exposed to a respiratory virus. If you join a respiratory virus challenge at NIH, you may help researchers discover better ways to monitor and understand illness using wearable devices and shared health data.
Bethesda, MarylandAges 18–65 - NCT04071847Recruiting
Study tracking results after Abbott deep brain stimulator surgery
This study follows people who are getting a new Abbott deep brain stimulator (DBS) device or replacing the battery/implantable pulse generator to see how outcomes change over time. It mainly applies to certain DBS targets and diagnoses, and it uses follow-up visits to track results.
Tucson, ArizonaAges Any age - NCT04629469Recruiting
Two types of MRI scans in children
This study compares two MRI scan settings (a lower and higher magnetic field) in children to see how well they work for pediatric patients. It may help doctors choose the best MRI approach for kids without changing any care beyond the scan itself.
Kansas City, MissouriAges birth–22 years - NCT04775914Recruiting
Test a heart procedure guide during emergency STEMI treatment
This trial studies whether adding a special heart “reset” step (ischemic postconditioning) and using an imaging guide during the emergency procedure can improve outcomes for people having a STEMI heart attack. It’s meant to optimize treatment when a blocked heart artery is being opened.
Copenhagen, Capital RegionAges 18 years+ - NCT04833465Recruiting
Testing a new outcome measure in kids with rheumatology diseases
This study looks at how to measure treatment success in children with juvenile idiopathic arthritis (JIA), lupus (SLE), or fibromyalgia (FM). It may help doctors track symptoms more reliably over time.
Washington D.C., District of ColumbiaAges 5–21 - NCT04797286RecruitingPhase 2
Sildenafil for early lung blood-pressure problems in scleroderma
This trial tests whether sildenafil can improve early “high pressure in the lung blood vessels” in people with scleroderma. It may help slow worsening breathing and lung blood-vessel disease before it becomes severe.
New Orleans, LouisianaAges 18 years+ - NCT04778761Recruiting
Video program to help with end-of-life care planning
This trial tests a video-based program that helps people with a life-limiting illness plan their future healthcare wishes. If you may benefit, it may make conversations about advance care planning easier and more structured.
Jersey City, New JerseyAges 21 years+ - NCT04778046RecruitingPhase 2
Study lung pressure treatment for people waiting for transplant
This Phase 2 trial is for adults with pulmonary hypertension who are on the lung transplant waiting list at Duke. It aims to test whether the study treatment can improve lung pressure and related health outcomes, while using things like MRI to monitor changes.
Durham, North CarolinaAges 18 years+ - NCT04786223Enrolling by invitationPhase 2
Testing an anti-inflammatory PET imaging treatment in memory loss
This Phase 2 study tests whether targeting “neuroinflammation” (inflammation in the brain) can help in Alzheimer’s disease and related memory disorders. You may help researchers by doing several brain scans (including a special PET/CT scan) along with MRI and amyloid imaging to understand what’s happening in the brain.
Rochester, MinnesotaAges 60 years+ - NCT04815694Recruiting
MRI-guided radiotherapy for rectal cancer
This trial tests whether using MRI scans to guide radiotherapy can improve treatment for people with a certain type of rectal cancer. It focuses on patients whose tumors have not spread to other parts of the body and who have specific tumor features seen on MRI.
Roma, RomaAges 18 years+ - NCT04784052RecruitingPhase 1/Phase 2
Briquilimab with reduced donor stem cell transplant for Fanconi anemia
This study tests whether a reduced-intensity donor stem cell transplant (with briquilimab as part of the conditioning) can safely treat bone marrow failure in people with Fanconi anemia. It may help by lowering how much intensive treatment is needed before the transplant, while still helping the donor cells grow.
Stanford, CaliforniaAges 2 years+ - NCT04777357RecruitingPhase 3
Cariprazine for bipolar depression in ages 10 to 17
This Phase 3 study tests whether cariprazine can improve depression symptoms in children and teens with bipolar I disorder, and also tracks side effects. It may help if your depressive episode is ongoing and you meet specific mood and screening score requirements.
Bentonville, ArkansasAges 10–17 - NCT04808505RecruitingPhase 3
Study of enzyme therapy for children with infant-onset Pompe disease
This trial tests how well a new enzyme treatment (cipaglucosidase alfa with miglustat) works and how safe it is in children and babies with infant-onset Pompe disease. It may help by improving muscle function after earlier treatment or, for some babies, starting treatment when no prior enzyme therapy has been given.
Gainesville, FloridaAges Up to 17 years - NCT04816773Enrolling by invitation
Long-term follow-up for specific knee replacement parts
This study follows people for up to 10 years after a knee replacement done with specific manufacturer parts. It helps the company and doctors understand how well these knee implants work and whether they cause any long-term problems.
Fremont, CaliforniaAges 21 years+
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Common questions
- Are there clinical trials for musculoskeletal diseases or conditions?
- Yes. Clin2 currently lists 4,021 recruiting musculoskeletal diseases or conditions studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a musculoskeletal diseases or conditions trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a musculoskeletal diseases or conditions trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.