Clinical trials
Neuropathy, Painful clinical trials
Below are recruiting neuropathy, painful clinical trials, each written for real people, not researchers. We’re tracking 60 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06914557RecruitingPhase 2
Scrambler therapy plus duloxetine for chemo nerve pain
This study tests whether adding a non-invasive device called Scrambler Therapy to the usual nerve pain medicine (duloxetine) can better relieve chemotherapy-induced nerve pain. It is for people with cancer who still have significant nerve pain despite taking duloxetine.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07427537Recruiting
Studying nerve damage from chemotherapy in colorectal and lung cancer patients
This study looks for small molecules in the blood that might predict nerve damage caused by certain chemotherapies. If you have colorectal or lung cancer and are starting a specific chemo plan, this trial could help researchers understand why some people get nerve problems and others don't.
Clermont-FerrandAges 18 years+ - NCT07298408RecruitingPhase 1/Phase 2
CBD for Diabetic Nerve Pain: A Pilot Study
This trial tests whether a daily dose of CBD (a cannabis compound) can help reduce nerve pain from type 2 diabetes. It's a small, early study to see if it's safe and effective.
Tallahassee, FloridaAges 40–70 - NCT07231419RecruitingPhase 3
Study of suzetrigine for diabetic nerve pain
This trial tests an experimental pain drug called suzetrigine for people with diabetic peripheral neuropathy (nerve damage from diabetes that causes pain in the feet and legs). It aims to see if the drug can safely reduce pain over time.
Birmingham, AlabamaAges 18–80 - NCT06619860RecruitingPhase 2
VX-993 for diabetic nerve pain
This trial tests a new medicine called VX-993 for people with diabetes who have had nerve pain in both feet or legs for at least a year. The goal is to see if it reduces pain and is safe.
Cullman, AlabamaAges 18–80 - NCT06628908RecruitingPhase 3
Study of suzetrigine for painful diabetic nerve damage
This trial tests an experimental medicine called suzetrigine to see if it can safely reduce pain caused by nerve damage from diabetes (diabetic peripheral neuropathy). It might be an option if you have had daily pain in both legs and current treatments haven't worked well enough.
Anniston, AlabamaAges 18–80 - NCT04687215Recruiting
Spinal cord stimulation for painful diabetic nerve pain
This trial studies whether a spinal cord stimulator can reduce pain from diabetic nerve damage in the legs. It focuses on people with long-lasting type 2 diabetes and significant, treatment-resistant pain.
Chicago, IllinoisAges 18 years+ - NCT07304401Recruiting
Closed-loop spinal cord stimulation for chemo-related nerve pain
This trial tests whether a new type of spinal cord stimulator (SCS) can reduce pain caused by chemotherapy. If you have lasting nerve pain after cancer treatment and standard pain medications haven't helped, this device might offer relief.
ArnhemAges 18 years+ - NCT06527183Recruiting
Fibromyalgia and small fiber nerve study
This study looks at whether people with fibromyalgia or long-term chronic pain have damage to the small nerve fibers in their skin. Understanding this could help develop better treatments.
Boulogne-BillancourtAges 18 years+ - NCT07390279Recruiting
Radiofrequency treatment for shingles-related nerve pain
This study tests a safe, non-surgical treatment called transcutaneous pulsed radiofrequency to see if it can help reduce nerve pain that continues after shingles. It targets the painful area through pads on the skin.
Istanbul, IstanbulAges 18 years+ - NCT06980948RecruitingPhase 1/Phase 2
Gene therapy study for nerve pain from small fiber neuropathy
This trial tests a new gene therapy called ST-503 for people with long-lasting nerve pain from small fiber neuropathy that hasn't improved with standard treatments. The study will check if the treatment is safe and tolerable.
Scottsdale, ArizonaAges 18 years+ - NCT05295498Recruiting
Brain stimulation trial for nerve pain relief
This trial studies whether repeated magnetic stimulation of the brain can reduce ongoing nerve pain. It may help people whose nerve pain has been steady for at least a month and who still need pain medicine more than once a week.
KrakowAges 18 years+ - NCT07352514Recruiting
Natural supplements and exercise for chemo nerve pain
This study tests if a combination of two natural supplements (PEA and Scutellaria) plus a specific exercise program can help reduce nerve pain caused by chemotherapy. It is for people who have had chemotherapy in the last 6 months and still have moderate to severe nerve pain.
Palermo, ItaliaAges 18 years+ - NCT05786599RecruitingPhase 2/Phase 3
Low-dose methadone for chemotherapy nerve pain
This trial studies whether methadone can reduce painful nerve damage caused by certain chemotherapy drugs. It is for adults who have ongoing nerve pain for months after chemotherapy ended and may help by lowering neuropathic (nerve) pain.
Nanaimo, British ColumbiaAges 19 years+ - NCT05747937Recruiting
Tracking nerve changes in people with ALS
This study follows people with ALS over time to learn how the body’s automatic nerves and nerve sensing (how you feel touch and pain) change. It may help researchers understand ALS better and guide future care.
Telese Terme, BeneventoAges 18 years+ - NCT05748015Recruiting
Checking how the nervous system is affected in multiple sclerosis
This study looks at signs of how your automatic “control” nerves (the autonomic nervous system) may be affected in people with multiple sclerosis. It may help researchers better understand different types of MS and how to recognize nervous-system involvement.
Telese Terme, BeneventoAges 18 years+ - NCT07126197Enrolling by invitation
Lymphovenous bypass for diabetic nerve pain
This study tests if a surgery called lymphovenous bypass can reduce nerve pain caused by diabetes. It may help people with diabetic peripheral neuropathy, even if they have foot ulcers.
TaipeiAges 20–80 - NCT07325851Recruiting
Ozone therapy for chronic pain when other options fail
This study is testing ozone therapy as a palliative treatment for people with chronic pain who haven't found relief from other options. It aims to see if adding ozone can improve pain and quality of life.
Las Palmas de Gran Canaria, Las PalmasAges 18 years+ - NCT07794475RecruitingPhase 1/Phase 2
Trimetazidine for diabetic nerve pain
This trial tests whether the drug trimetazidine can improve nerve damage symptoms in people with type 2 diabetes and diabetic neuropathy. It also looks at how the drug affects a substance in the blood called endothelin-1, which may be involved in nerve damage.
CairoAges 18–65 - NCT04909138Recruiting
Intermittent nerve stimulation instead of daily low-frequency therapy
This study tests whether switching from continuous implanted nerve stimulation to an intermittent schedule can keep pain relief for people with chronic back and/or leg pain. You would be compared in a structured study plan to see if the alternate dosing works for you and is safe.
Chicago, IllinoisAges 18–90 - NCT06834685Recruiting
Laser therapy for nerve pain after chemotherapy
This study tests a special laser treatment (photobiomodulation) to reduce nerve pain caused by chemotherapy in cancer patients. If you have had nerve pain for at least 3 months after chemo and can attend twice-weekly sessions, this may help ease your pain.
Mougins, Alpes MaritimesAges 18 years+ - NCT07779135Recruiting
Aromatherapy for nerve pain from breast cancer treatment
This study tests whether using essential oils can help reduce pain, tingling, or numbness in hands and feet caused by paclitaxel chemotherapy for breast cancer. If regular pain medications aren't working well, this natural approach may offer additional relief.
ColmarAges 18 years+ - NCT06744816RecruitingEarly Phase 1
Can capsaicin cream ease nerve pain after chemotherapy?
This study tests whether a capsaicin cream (made from chili peppers) can help reduce pain in the legs caused by nerve damage from past chemotherapy. It's for people who still have pain 3 months or more after finishing chemo.
Houston, TexasAges 18 years+ - NCT06162403Recruiting
Nerve stimulation for chemo-related leg pain
This study tests whether a small device that sends gentle electrical pulses to nerves in your leg can relieve pain caused by chemotherapy. If you have ongoing nerve pain in your legs from past chemo, this treatment might offer a new way to manage it.
Houston, TexasAges 18–85
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Common questions
- Are there clinical trials for neuropathy, painful?
- Yes. Clin2 currently lists 60 recruiting neuropathy, painful studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a neuropathy, painful trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a neuropathy, painful trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.