Clinical trials
Painful Diabetic Neuropathy clinical trials
Below are recruiting painful diabetic neuropathy clinical trials, each written for real people, not researchers. We’re tracking 64 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06619860RecruitingPhase 2
VX-993 for diabetic nerve pain
This trial tests a new medicine called VX-993 for people with diabetes who have had nerve pain in both feet or legs for at least a year. The goal is to see if it reduces pain and is safe.
Cullman, AlabamaAges 18–80 - NCT06544876Recruiting
Balance and recovery in diabetes nerve damage
This study looks at how diabetes-related nerve damage affects balance and the ability to recover from a stumble. It may help find better ways to prevent falls.
Austin, TexasAges 50–99 - NCT06628908RecruitingPhase 3
Study of suzetrigine for painful diabetic nerve damage
This trial tests an experimental medicine called suzetrigine to see if it can safely reduce pain caused by nerve damage from diabetes (diabetic peripheral neuropathy). It might be an option if you have had daily pain in both legs and current treatments haven't worked well enough.
Anniston, AlabamaAges 18–80 - NCT06158529Recruiting
High-frequency spinal cord stimulation for diabetic nerve pain
This trial tests if a special type of spinal cord stimulation (high-frequency SCS) can better relieve painful nerve damage caused by diabetes. If you have long-term burning, stabbing, or electric-shock-like pain in both legs, this treatment may help reduce that pain.
BeijingAges 18–80 - NCT07231419RecruitingPhase 3
Study of suzetrigine for diabetic nerve pain
This trial tests an experimental pain drug called suzetrigine for people with diabetic peripheral neuropathy (nerve damage from diabetes that causes pain in the feet and legs). It aims to see if the drug can safely reduce pain over time.
Birmingham, AlabamaAges 18–80 - NCT07209514Enrolling by invitation
Testing a spinal cord stimulator for diabetic nerve pain in the legs
This trial is studying a device called the Medtronic Inceptiv™ Closed-Loop DTM Spinal Cord Stimulator to see if it can help reduce pain from diabetic peripheral neuropathy (nerve damage caused by diabetes) in the lower legs. It is for people whose pain has lasted at least 6 months and hasn't been helped by other treatments.
Grand Island, NebraskaAges 19 years+ - NCT07743073Recruiting
Ceylon cinnamon for diabetic nerve pain
This study tests whether taking Ceylon cinnamon daily can help lower blood sugar, improve cholesterol, and reduce nerve pain in adults with type 2 diabetes and painful diabetic peripheral neuropathy. If you qualify, you might get a natural supplement that could ease your symptoms.
AmmanAges 18 years+ - NCT07712913RecruitingPhase 3
Pregabalin for nerve pain from diabetes or shingles
This trial tests an extended-release version of pregabalin (a pain medication) for people with long-term nerve pain caused by diabetes or shingles. It aims to see if this once-daily pill can reduce pain with fewer side effects.
Salvador, Estado de BahiaAges 18–75 - NCT04678895RecruitingPhase 2
Low-dose naltrexone for nerve pain from diabetes
This Phase 2 trial studies whether a low dose of naltrexone can reduce painful nerve pain caused by diabetes. It may help people whose diabetic nerve pain did not improve with at least one standard treatment.
Lebanon, New HampshireAges 18 years+ - NCT04687215Recruiting
Spinal cord stimulation for painful diabetic nerve pain
This trial studies whether a spinal cord stimulator can reduce pain from diabetic nerve damage in the legs. It focuses on people with long-lasting type 2 diabetes and significant, treatment-resistant pain.
Chicago, IllinoisAges 18 years+ - NCT04699734Recruiting
Nerve block for nerve pain from diabetes
This trial studies whether a numbing “nerve block” can reduce long-lasting nerve pain caused by diabetic neuropathy. You may keep your usual pain medicines, and the study will mainly check whether you fit the safety and diagnosis criteria.
Aarhus N, JutlandAges 18 years+ - NCT05483816Recruiting
Sensory stimulation trial for nerve pain in people with neuropathy
This study tests a multi-sensory (multiple-sense) stimulation approach to see if it can help people with nerve-related pain in the legs/feet. You must be able to safely take part in MRI-related sessions and answer questions about pain and health history.
Zurich, Canton of ZurichAges 18–80 - NCT05623111RecruitingPhase 2
Nerve-area Botox shots for diabetic foot nerve pain
This Phase 2 trial tests whether injecting incobotulinumtoxin-A near painful nerves can reduce nerve-type pain in the feet for people with diabetes. If you have lasting, fairly symmetrical pain in both feet, the injections may help calm the nerve pain signals.
Glostrup MunicipalityAges 18 years+ - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT06471517Recruiting
Nerve device for diabetic foot numbness
This trial tests a special device that uses mild electrical pulses to help improve problems caused by diabetic nerve damage, such as numbness and pain in the feet. If you have diabetic neuropathy and can walk on your own, this study may be a good option.
BelgradeAges 18 years+ - NCT06479577Recruiting
Comparing ultrasound and laser therapy for diabetic foot pain
This study compares two physical therapy methods (ultrasound and high-intensity laser therapy) to see which one better reduces nerve pain, improves strength, and boosts quality of life in people with diabetic foot pain.
Bahawalpur, Punjab ProvinceAges 50–75 - NCT06480786Recruiting
Spinal cord stimulator for diabetic nerve and artery pain
This study tests if a spinal cord stimulator (a device that sends mild electrical pulses to the spine) can relieve severe leg pain caused by diabetic nerve damage and poor blood flow. It may help people who have not found enough relief from other treatments.
Omaha, NebraskaAges 19–89 - NCT06483620Recruiting
Arabic quality of life questionnaire for diabetic neuropathy
This trial tests a new Arabic questionnaire to measure quality of life for people with diabetic neuropathy. It helps doctors understand how nerve pain affects daily life.
Cairo, Giza GovernorateAges 18–70 - NCT06591780Recruiting
Biofeedback to improve walking for diabetic nerve damage
This study tests a special biofeedback system to help people with diabetic nerve damage walk better. You'll use sensors during treadmill walking to see if real-time feedback can improve your stride and balance.
Pensacola, FloridaAges 45–90 - NCT06603792RecruitingEarly Phase 1
Neurofeedback for diabetic nerve pain
This trial tests whether a brain-training technique called neurofeedback can help reduce nerve pain caused by diabetes. It is for people with type 1 or type 2 diabetes who have had moderate-to-severe nerve pain for at least 3 months.
OdenseAges 18–82 - NCT06614322RecruitingPhase 2
Testing Pain Sensitivity and Pain Relief for Nerve Pain in Feet
This study looks at how people with long-term nerve pain in their feet respond to pain relief. It aims to match the right treatment to each person based on their pain sensitivity.
Boston, MassachusettsAges 18–80 - NCT06668623Recruiting
Reiki for nerve pain and sleep in diabetic neuropathy
This trial tests if Reiki, a gentle hands-on energy therapy, can reduce nerve pain and improve sleep in people with diabetic neuropathy. It may offer a non-drug option for managing symptoms.
Kayseri, KocasinanAges 18–70 - NCT06798181Recruiting
Neuropathic pain and type 2 diabetes study
This study looks at nerve pain (called neuropathic pain) in people with type 2 diabetes. It aims to understand this type of pain better so doctors can help improve comfort and quality of life.
BilecikAges 18–100 - NCT07078565Recruiting
Tai Chi vs. Otago Exercises for Diabetic Nerve Pain
This study compares gentle Tai Chi exercises with a modified Otago exercise program to see which better helps with pain, balance, and movement in people with diabetic nerve pain. If you have had type 2 diabetes for at least 5 years and have chronic nerve pain, this trial may help you find relief and improve your mobility.
Lahore, Punjab ProvinceAges 40–80
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Common questions
- Are there clinical trials for painful diabetic neuropathy?
- Yes. Clin2 currently lists 64 recruiting painful diabetic neuropathy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a painful diabetic neuropathy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a painful diabetic neuropathy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.