Clinical trials
Nicotine Use Disorder clinical trials
Below are recruiting nicotine use disorder clinical trials, each written for real people, not researchers. We’re tracking 156 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06790576RecruitingPhase 1
Optimizing TMS for stimulant use disorder
This test uses a safe, non-invasive brain stimulation method called TMS (transcranial magnetic stimulation) to see if it can help people with stimulant use disorder reduce their cravings and stay sober. You would need to be in an addiction treatment program and have been clean for at least 2 weeks to join.
Minneapolis, MinnesotaAges 18 years+ - NCT07490600Recruiting
Testing brain stimulation and rewards for quitting cocaine
This trial combines deep transcranial magnetic stimulation (TMS) with a reward program (contingency management) to help people stop using cocaine. It may help if you are struggling with moderate to severe cocaine use and want a non-drug treatment.
Houston, TexasAges 18–65 - NCT06320366Recruiting
Faster TMS for methamphetamine use disorder
This study tests a faster brain stimulation technique (TMS) to help people reduce methamphetamine use. It may be a good option if you have moderate to severe methamphetamine use disorder and are looking for new treatment approaches.
Aurora, ColoradoAges 21–65 - NCT06457243Recruiting
Brain stimulation for methamphetamine use disorder
This trial tests a type of brain stimulation (called cTBS) to see if it can reduce methamphetamine cravings and improve thinking. If you are in recovery or still using, you may be able to join.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT04066192RecruitingPhase 2
Brexpiprazole trial for alcohol use disorder in adults
This study tests whether brexpiprazole can help adults with alcohol use disorder. You must currently not be taking alcohol-focused treatment or alcohol medicines, and you’ll likely complete questionnaires and brain scans.
Aurora, ColoradoAges 21–65 - NCT05408247RecruitingPhase 4
N-acetylcysteine to help people cut back on alcohol
This trial tests whether N-acetylcysteine (a supplement-like medicine) can help people with alcohol use disorder reduce or stop drinking. You may be randomly assigned to receive N-acetylcysteine or a comparison treatment, and you’ll complete interviews during the study.
Sydney, New South WalesAges 18–70 - NCT05452772RecruitingPhase 2
Psilocybin plus niacin to help quit smoking
This Phase 2 study tests whether a psilocybin “session” with niacin can help people quit smoking. It’s for adults who smoke daily and want to quit but have tried and struggled before.
Birmingham, AlabamaAges 21 years+ - NCT05587361RecruitingPhase 4
Nicotine cue study using propranolol to study craving
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
Tulsa, OklahomaAges 21–60 - NCT05781009RecruitingPhase 2
Pregnenolone treatment for alcohol use disorder
This Phase 2 study tests pregnenolone to help reduce or improve alcohol use disorder symptoms. It looks for adults who drink regularly and meet diagnostic criteria for moderate to severe alcohol use disorder, while excluding people with certain other substance use, medicines, or serious mental/medical conditions.
New Haven, ConnecticutAges 18–70 - NCT05859347Recruiting
Brain stimulation study for cannabis use disorder
This trial tests whether a treatment called repetitive transcranial magnetic stimulation (a non-surgical magnetic stimulation to the brain) can help people reduce or stop cannabis use. You may be eligible if you have cannabis use disorder and meet specific safety and symptom criteria.
Toronto, OntarioAges 18–65 - NCT05986578Recruiting
Brain stimulation for cocaine use disorder
This study tests whether brain stimulation can help people with cocaine use disorder. It is a research study that aims to identify brain targets for treatment with a non-invasive technique called transcranial magnetic stimulation (TMS).
Houston, TexasAges 18–65 - NCT05988632RecruitingPhase 1/Phase 2
Insulin nasal spray for alcohol use disorder
This trial tests whether a nasal spray with insulin can help people with alcohol use disorder. It may affect how the brain responds to alcohol and reduce drinking.
Providence, Rhode IslandAges 21 years+ - NCT05995769RecruitingPhase 2
Psilocybin therapy with talk therapy for alcohol problems
This trial tests whether psilocybin (the active ingredient in magic mushrooms), given with talk therapy, can help people who want to reduce their heavy drinking. It is for people with at least moderate alcohol use disorder who are motivated to change.
Calgary, AlbertaAges 22–65 - NCT05997212Recruiting
Can brain stimulation help with thinking skills in alcohol use disorder?
This study tests if a noninvasive brain stimulation technique called repetitive TMS (rTMS) can improve thinking skills like decision-making and focus in people recovering from alcohol use disorder. You must have been alcohol-free for 8 weeks to 5 years.
Querétaro City, QuerétaroAges 25–59 - NCT06105853Recruiting
Stress and brain activity in alcohol use disorder
This study looks at how people with alcohol use disorder respond to stress and what happens in the brain. You'll use a smartphone and may have an MRI scan to understand your stress responses.
Mannheim, Baden-WurttembergAges 18–65 - NCT06643988Recruiting
Memory and thinking study for opioid use disorder
This study looks at how people with opioid use disorder remember personal events. You'll do tasks on a cellphone and at home while taking medication for opioid use disorder.
Philadelphia, PennsylvaniaAges 18–60 - NCT06415721Recruiting
TMS guided by brain scans for alcohol use disorder
This study uses a brain stimulation technique called TMS combined with MRI scans to treat alcohol use disorder. It aims to see if targeting specific brain connections can help reduce drinking.
Palo Alto, CaliforniaAges 25–75 - NCT06426303RecruitingPhase 4
Alcohol Use Disorder Treatment in Veterans: Brain and Inflammation
This study is for veterans with alcohol use disorder who have been sober for 5 days to 3 weeks. It looks at how trauma, inflammation, and brain function relate to alcohol problems and how well treatment works. You will be in a group that gets medication or a placebo.
Portland, OregonAges 18–60 - NCT06512389RecruitingPhase 2
Testing CBD for alcohol cravings
This study tests whether a medication called cannabidiol (CBD) can help reduce cravings for alcohol. Over several weeks, you will take the study pill and attend lab sessions where you can choose to drink alcohol in a safe setting.
Toronto, OntarioAges 19 years+ - NCT06538558RecruitingPhase 1
Study of tezampanel for opioid withdrawal
This trial tests if tezampanel can help relieve withdrawal symptoms in people with opioid use disorder who are seeking treatment. Participants must already be in an outpatient addiction program.
Indianapolis, IndianaAges 18–65 - NCT06559995RecruitingPhase 2/Phase 3
Ketone drink for alcohol withdrawal
This study tests whether a special ketone drink can ease alcohol withdrawal and help your brain heal. If you have been drinking heavily for at least 3 years and are having withdrawal symptoms now, this might be an option for you.
Philadelphia, PennsylvaniaAges 18–65 - NCT06620276Recruiting
Ketamine and therapy for alcohol use disorder and depression
This trial tests if combining ketamine infusions with weekly therapy can help people who have both alcohol use disorder and hard-to-treat depression. You may qualify if you drink at least moderately, have treatment-resistant depression, and are willing to attend 8 therapy sessions.
Montreal, QuebecAges 18–70 - NCT06866379Recruiting
Brain study on alcohol use disorder: septal nuclei
This study uses brain scans (fMRI) to look at a small area deep in the brain called the septal nuclei, which may play a role in alcohol use disorder. It aims to understand how the brain's structure and activity relate to heavy drinking, which could lead to better treatments.
FrederiksbergAges 30–65 - NCT06870110Recruiting
Brain training for opioid use disorder
This trial tests a brain-training program for people with opioid use disorder. It uses an EEG headset to measure brain activity while you do computer exercises, and aims to see if this training can help recovery.
Minneapolis, MinnesotaAges 18–65
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Common questions
- Are there clinical trials for nicotine use disorder?
- Yes. Clin2 currently lists 156 recruiting nicotine use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a nicotine use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a nicotine use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.