Clinical trials · California
Obesity & Overweight clinical trials in California
We’re tracking 69 recruiting obesity & overweight studies with a site in California — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07743463RecruitingPhase 3
Daily pill for weight loss in adults with excess weight or weight-related health issues
This study tests a once-daily pill called ASC30 to help adults with obesity or overweight who also have conditions like high blood pressure, sleep apnea, or heart disease lose weight. The pill may work by affecting appetite and blood sugar, and the study aims to see how effective and safe it is.
Banning, CaliforniaAges 18 years+ - NCT07843472RecruitingPhase 3
Petrelintide for weight loss in people with heart disease
This study tests a new medication called petrelintide to help people with overweight or obesity and heart disease lose weight. It may offer a new way to manage weight and improve heart health.
Los Angeles, CaliforniaAges 40 years+ - NCT07843485RecruitingPhase 3
Weight loss medication for adults with type 2 diabetes
This study tests a new medicine called petrelintide to help people with excess weight and type 2 diabetes lose weight and improve blood sugar control. It may be an option if you've struggled with weight loss through diet alone.
Los Angeles, CaliforniaAges 18 years+ - NCT06937086RecruitingPhase 3
Mirikizumab plus tirzepatide for UC with obesity
This study tests whether adding mirikizumab to the weight-loss drug tirzepatide helps people with moderate-to-severe ulcerative colitis who also have obesity or overweight. It aims to see if the combination reduces bowel inflammation and helps with weight management.
Anaheim, CaliforniaAges 18–70 - NCT07654374RecruitingPhase 3
Study of a new pill for weight loss and diabetes
This study tests a new daily pill (aleniglipron) to help adults with excess weight and type 2 diabetes lose weight and improve blood sugar control. It may be a good fit if you have a BMI of 27 or higher and your diabetes is managed with A1c between 6.5% and 10%.
Escondido, CaliforniaAges 18–79 - NCT07794579RecruitingPhase 3
Study of orforglipron for people with overweight at risk of health problems
This trial tests a new medicine, orforglipron, to help people with overweight who are at risk of developing weight-related health issues. It aims to see if the medicine can help with weight management and reduce risks before more serious conditions develop.
Lake Forest, CaliforniaAges 18 years+ - NCT07654361RecruitingPhase 3
A new pill for weight loss in obesity and overweight
This study tests an investigational pill called aleniglipron to see if it helps people with obesity or overweight who also have a weight-related health problem (like high blood pressure) lose weight safely. It is a Phase 3 trial, meaning it is in the final stages before seeking approval.
Escondido, CaliforniaAges 18–79 - NCT06857942RecruitingPhase 4
Tirzepatide added to ixekizumab for psoriasis and weight issues
This trial tests whether adding tirzepatide (a weight-loss and diabetes drug) to ixekizumab (a psoriasis treatment) helps people with moderate-to-severe psoriasis who are overweight or have obesity. It is for those already taking ixekizumab for about 3 months.
Fountain Valley, CaliforniaAges 18 years+ - NCT07776678Recruiting
Body fat and muscle measurement study
This study uses advanced body scans (like MRI and DXA) to better measure body fat and muscle. It may help improve how obesity is diagnosed and treated.
Menlo Park, CaliforniaAges 18 years+ - NCT07784725RecruitingPhase 3
Study of a weight loss injection for adults with obesity
This study tests a new medicine to help adults with obesity or overweight lose weight. It's for people who have had trouble losing weight in the past and don't have diabetes.
Escondido, CaliforniaAges 18 years+ - NCT07776509RecruitingPhase 3
Adding a new drug to current weight-loss therapy for adults with obesity or overweight
This study tests a new medication (AZD6234) added to your current weight-management medication (an incretin-based drug) to see if it helps with weight loss. You may be eligible if you are overweight or obese with related health issues or type 2 diabetes.
Escondido, CaliforniaAges 18 years+ - NCT07823608RecruitingPhase 3
Monthly study medicine for adults with sleep apnea and overweight who use a breathing machine
This study tests an investigational medicine taken once a month for adults with moderate to severe sleep apnea who are overweight or have obesity and use a CPAP or similar breathing machine. It aims to see if the medicine improves sleep-related breathing.
Riverside, CaliforniaAges 18 years+ - NCT07090005Recruiting
Endoscopic weight loss: comparing EndoZip and Apollo ESG
This study compares two different endoscopic procedures (EndoZip and Apollo ESG) to help obese patients lose weight. Both are done through the mouth without cutting the skin, and the goal is to see which works better and is safer.
Los Angeles, CaliforniaAges 21–65 - NCT06067763Enrolling by invitation
Project Health: Preventing unhealthy weight gain in young adults
This study tests a program to help young adults improve their eating and exercise habits, with the goal of preventing obesity. It is designed for people who are concerned about their weight and want to make healthier lifestyle choices.
Stanford, CaliforniaAges 17–20 - NCT06924320RecruitingPhase 1/Phase 2
Study of two medicines for weight loss and diabetes
This study tests two investigational medications, MET233 and MET097, in people with obesity or overweight, with or without type 2 diabetes. It aims to see if the combination can help with weight loss and blood sugar control.
Cypress, CaliforniaAges 18–75 - NCT07511205RecruitingPhase 1
Study of AZD1043 for overweight or obesity
This trial tests a new medicine called AZD1043 in healthy adults who are overweight or have obesity. It aims to see if the medicine is safe and how the body handles it.
Glendale, CaliforniaAges 18–65 - NCT07846033RecruitingPhase 1
Study of the experimental drug VK3019 for adults with overweight or obesity
This early-phase study tests an experimental medicine called VK3019 in adults who are overweight or have obesity but are otherwise healthy. The goal is to see if the drug is safe and how the body handles it, which may lead to future weight-management options.
Lake Forest, CaliforniaAges 18–60 - NCT07392190RecruitingPhase 3
Study of eloralintide for people with persistent obesity
This trial tests if adding eloralintide helps people who are still obese or overweight while taking weekly incretin therapy. It aims to support additional weight loss for those who haven't reached their goals.
San Diego, CaliforniaAges 18 years+ - NCT07837973RecruitingPhase 2
Medicine to maintain weight loss after weight-loss shots
This study tests a new medicine called ALV-100 to see if it can help people who have already lost weight with a weight-loss injection or pill keep the weight off. You must be currently on a stable weight-loss medicine and have lost at least 10% of your body weight to join.
Oceanside, CaliforniaAges 18–75 - NCT07806838Recruiting
Dietary supplements to preserve muscle during GLP-1 weight loss
This study looks at whether certain dietary supplements can help preserve muscle mass while you are taking a GLP-1 medication for weight loss. You would take the supplements or a placebo for a period while continuing your GLP-1 treatment, and the researchers will measure changes in your muscle and strength.
Los Angeles, CaliforniaAges 18 years+ - NCT07770841RecruitingPhase 3
Oral medication for weight loss study
This study tests an oral medicine (semaglutide) to see if it helps adults with excess weight lose weight. It might offer an easier, pill-based treatment option for weight management.
Escondido, CaliforniaAges 18 years+ - NCT07720271RecruitingPhase 3
Zenagamtide weight loss study for adults
This study is testing a new tablet called Zenagamtide to help people with extra body weight lose weight. It's for adults who are not diabetic and haven't used similar weight loss drugs before.
Walnut Creek, CaliforniaAges 18 years+ - NCT07710768RecruitingPhase 1
A study on how UBT251 affects certain drugs in people with extra weight
This study tests if a new medicine called UBT251 changes how the body processes caffeine, midazolam (a sedative), and warfarin (a blood thinner). It is for generally healthy adults with a Body Mass Index (BMI) between 27 and 40.
Cypress, CaliforniaAges 18–65 - NCT07684235RecruitingPhase 3
Long-term study of a weight-loss drug for trial graduates
This study tests a drug called Maridebart Cafraglutide for long-term weight management in people who completed a previous related trial. It looks at how well the drug works and its safety over time.
Fountain Valley, CaliforniaAges 18–99
Obesity & Overweight trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting obesity & overweight studies listed above.
- Artemis Institute for Clinical Research · 3 studies
- Diablo Clinical Research · 3 studies
- Research Site · 3 studies
- Cedars-Sinai Medical Center · 2 studies
- Institute for Metabolic Research Los Angeles · 2 studies
- Southern California Clinical Research · 2 studies
- ACCOMPLISH-1 Research Site
- ACCOMPLISH-2 Research Site
What taking part in a obesity & overweight study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Obesity & Overweight trials in other states
Common questions
- Are there obesity & overweight clinical trials in California?
- Yes. We're currently tracking 69 recruiting obesity & overweight studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a obesity & overweight study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a obesity & overweight trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New obesity & overweight studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.