Clinical trials
Oral Disease clinical trials
Below are recruiting oral disease clinical trials, each written for real people, not researchers. We’re tracking 193 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06600178RecruitingPhase 1
Heart medication for women with chest pain and small vessel disease
This trial tests a diabetes medication called SGLT2 inhibitors to see if it can improve blood flow to the heart and reduce chest pain in women who have small vessel heart disease (microvascular dysfunction) but not blocked large arteries. Participants will take the medication and be monitored for symptom relief and heart function improvements.
Charlottesville, VirginiaAges 18 years+ - NCT06817031Enrolling by invitationPhase 2
Probiotics for gut health in pregnancy – Bangladesh study
This study tests whether a daily probiotic capsule during pregnancy can improve the health of a mother's gut, especially if she is exposed to unclean water or poor sanitation. Pregnant women early in their second trimester who live in the Matlab area of Bangladesh may join.
ChāndpurAges 18 years+ - NCT07714746RecruitingPhase 3
Ivabradine for treating cardiogenic shock after heart attack
This trial tests if ivabradine, a drug that lowers heart rate, can help patients in cardiogenic shock after a type of heart attack called STEMI. It is for patients with a fast heart rate (at least 100 beats per minute) who cannot take beta-blockers.
KarachiAges 18–75 - NCT04381143RecruitingPhase 4
Aspirin to prevent problems in people on dialysis
This trial studies whether taking aspirin can reduce heart and clot-related complications in adults receiving long-term dialysis. It may help by improving blood clotting behavior, but it also requires that aspirin is safe for you.
Fuzhou, FujianAges 18 years+ - NCT04895436RecruitingPhase 2
Oral venetoclax plus IV obinutuzumab after prior CLL treatment
This trial tests whether adding oral venetoclax together with an IV antibody called obinutuzumab can control CLL when the disease comes back after a specific prior treatment. It also looks closely at side effects to see what changes in “disease activity” and safety to expect.
La Jolla, CaliforniaAges 18 years+ - NCT05889182RecruitingPhase 3
Testing an oral medicine for moderate to severe hidradenitis
This Phase 3 study tests upadacitinib taken by mouth to reduce hidradenitis suppurativa (HS) symptoms and disease activity, and to track side effects. It is for people who have already tried anti-TNF treatments and still had inadequate response or couldn’t tolerate them.
Birmingham, AlabamaAges 12 years+ - NCT07403604RecruitingPhase 1
Lowering Insulin to Reduce Fat Buildup in the Liver
This study tests if lowering insulin levels can reduce fat buildup in the liver for people with a fatty liver condition called MASLD. It's looking for adults who are overweight and have early signs of insulin resistance but not diabetes.
New York, New YorkAges 18–65 - NCT07276997RecruitingPhase 2
Study of Icalcaprant for major depressive disorder
This trial tests an oral medication called icalcaprant for adults with major depressive disorder (MDD). It aims to see if the drug can reduce depression symptoms and what side effects may occur.
Dothan, AlabamaAges 18–65 - NCT03809728Recruiting
Finding blood tests linked to outcomes in Crohn’s and colitis
This study looks for “biomarkers” (lab markers, like substances in blood or tissue) that may predict how Crohn’s disease or ulcerative colitis will go and how patients may respond. It may help doctors choose better monitoring or treatments in the future.
Vandœuvre-lès-NancyAges 18 years+ - NCT03991169RecruitingPhase 4
Oral iron for children with chronic kidney disease
This trial studies whether taking iron by mouth can improve iron levels and anemia (low red blood cell counts) in children with chronic kidney disease. It may help reduce fatigue and support normal blood-making, by comparing different approaches for children who meet specific iron test results.
New York, New YorkAges 1–21 - NCT05413655RecruitingPhase 2
Oral drug for mild Alzheimer’s disease symptoms
This Phase 2 trial tests an oral medicine (EX039) to see if it can help people with mild Alzheimer’s disease. It focuses on slowing or improving thinking and memory problems over time.
TaipeiAges 50–80 - NCT07476703Recruiting
Extended study on the SCAPIS Stockholm reexamined group
This trial studies data and samples from people already taking part in the main SCAPIS reexamination study in Stockholm. It looks for new findings to help understand heart and lung health.
StockholmAges 56–74 - NCT07296965Recruiting
Oral bacteria in carotid artery plaque study
This study looks at the bacteria living in your mouth and whether they are linked to plaque buildup in the carotid artery (the main artery in your neck). If you are already scheduled for surgery to remove that plaque, the researchers will take samples from your mouth and the plaque to compare them.
BudapestAges 18 years+ - NCT07187388Recruiting
Electrical stimulation for jaw pain in motor neuron disease
This study tests whether gentle electrical stimulation around the jaw can ease facial pain, improve jaw movement, and help oral health in people with certain motor neuron diseases like ALS or PLS. It may be a good fit if you have jaw pain and meet a few health conditions.
Davie, FloridaAges 18 years+ - NCT05232331Recruiting
Eat nitrate-rich vegetables to study gum inflammation and mouth bacteria
This study looks at whether eating more nitrate-rich vegetables changes inflammatory markers and the balance of bacteria in the mouth for people with periodontitis (serious gum disease). It may help us understand better diet-based support alongside standard non-surgical gum treatment.
Guadalajara, JaliscoAges 30–65 - NCT05688982Recruiting
Check oral health needs and local care resources in the ER
This study asks people in the emergency department (and their parents/guardians) about oral health needs and what local resources they can access. It aims to map gaps in dental and oral health support so future care can be better targeted.
Boston, MassachusettsAges 1 year+ - NCT06021808Recruiting
LAA clip vs. blood thinners to prevent stroke in non-paroxysmal AF
This study compares two ways to prevent stroke in people with persistent or long-standing atrial fibrillation (AF): taking a blood thinner (NOAC) or having a minimally invasive procedure to clip off the left atrial appendage (LAA). The goal is to see which approach works better at preventing stroke without causing major bleeding.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06110143Recruiting
Gum health and pregnancy complications study
This study looks at how gum disease (periodontitis) during pregnancy might affect pregnancy outcomes. It may help you if you have gum disease and want to learn more about its impact on your pregnancy.
Holbæk, HolbaekAges 16–48 - NCT07025629RecruitingPhase 3
Dapagliflozin after ICU discharge for heart and kidney health
This study tests if the drug dapagliflozin (a medicine that helps protect the heart and kidneys) can improve recovery in patients who needed a breathing machine or blood pressure support in the ICU. If you qualify, you would take the drug after leaving the ICU to see if it lowers the risk of heart or kidney problems.
ParisAges 18 years+ - NCT07281456RecruitingPhase 2
Testing a new oral drug for Sjögren's disease safety
This study tests the safety of a daily pill called Tofacitinib for adults with mild-to-moderate Sjögren's disease. It aims to see if this drug helps manage symptoms when other treatments haven't worked well.
Bethesda, MarylandAges 18–75 - NCT07045493Enrolling by invitationPhase 2
Combination therapy for soil-transmitted worms in children aged 2-5
This trial tests whether a combination of medicines works better than a single medicine to treat common intestinal worms (like hookworm and roundworm) in young children in Bangladesh. It is for children who are either stunted (shorter than average for their age) or healthy, and who have a confirmed worm infection.
DhakaAges 2–5 - NCT05800275RecruitingPhase 2
Tucatinib and capecitabine plus spinal trastuzumab for HER2+ cancer
This Phase 2 trial tests a combination of tucatinib and capecitabine (taken by mouth) plus trastuzumab delivered into the spinal fluid, to treat breast cancer that has spread to the leptomeninges (lining around the brain/spinal cord). It may help reduce cancer activity in the spinal fluid and improve symptoms.
BordeauxAges 18 years+ - NCT06620523RecruitingPhase 2
Preventing kidney injury after heart bypass surgery
This trial tests whether combining two natural supplements (CoQ10 and glutathione) can protect your kidneys during heart bypass surgery. It may help prevent acute kidney injury, a common complication after these procedures.
Washington D.C., District of ColumbiaAges 18–70 - NCT07563582Recruiting
Iron Supplement for Children with Celiac Disease and Low Iron
This study tests whether a special iron supplement taken by mouth helps children who have celiac disease (a condition where the body can't digest gluten) and low iron levels or anemia (not enough healthy red blood cells). The iron supplement is designed to be easily absorbed by the body.
Genova, ItalyAges 8–18
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Common questions
- Are there clinical trials for oral disease?
- Yes. Clin2 currently lists 193 recruiting oral disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a oral disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a oral disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.