Clinical trials
Oral Microbiome clinical trials
Below are recruiting oral microbiome clinical trials, each written for real people, not researchers. We’re tracking 25 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05830591Recruiting
Gut microbiome study in autism in children
This trial studies differences in the gut bacteria (microbiome) between children with autism and healthy children. It may help researchers understand what roles the gut may play in autism and guide future treatments.
TriesteAges 1–17 - NCT07111455Recruiting
Oral bacteria changes with chemoimmunotherapy for mouth cancer
This study is testing whether a combination of chemotherapy and immunotherapy before surgery can help treat advanced oral cancer. Researchers will also look at how the cancer changes the bacteria in your mouth.
Guangzhou, GuangdongAges 18–80 - NCT07761546Enrolling by invitation
Ai-test: microbiome nutrition for low testosterone
This study tests whether a special diet can improve symptoms of low testosterone in men. It is intended to help men with certain symptoms like a low sex drive or trouble having erections and whose blood tests show low to borderline testosterone levels.
AydinAges 30–65 - NCT02898818Recruiting
Study of interactions between vaginal and oral microbiomes
This study looks at how the bacteria (microbes) in the vagina and in the mouth may affect each other. It may help improve understanding of vaginal health and related conditions.
Turku, TurkuAges 18 years+ - NCT07622628Recruiting
AI-Guided Microbiome Nutrition for Better Blood Sugar Control
This trial tests whether a personalized nutrition plan based on your gut bacteria (microbiome) can help improve blood sugar control in type 2 diabetes. Researchers will use artificial intelligence to match you with a diet tailored to your unique gut bacteria.
IzmirAges 18–65 - NCT05603650Recruiting
Mouthwash study for healthy bacteria in your mouth and gut
This study tests how a mouthrinse changes the helpful bacteria in your mouth and stomach/gut. You may need several visits and phone follow-ups to see how your microbiome shifts over time.
Irvine, CaliforniaAges 18 years+ - NCT06724133Recruiting
Mouth bacteria and colon polyps study
This study looks at the bacteria in your mouth and how they might be linked to colon polyps. Researchers want to see if certain mouth bacteria affect the body's immune system and increase the risk of polyps.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05133102Recruiting
Collecting saliva to study Barrett’s esophagus over time
This study collects saliva (and, for some people, looks at stomach/esophagus samples) to understand how the mouth and gut “microbiome” changes over time in people with Barrett’s esophagus. It may help researchers find patterns that relate to Barrett’s esophagus and future risk.
Ann Arbor, MichiganAges 18 years+ - NCT06124833Recruiting
Gut and mouth microbiome study for Korean IBD patients and their family
This study looks at the bacteria in your gut and mouth to understand more about inflammatory bowel disease (IBD). It compares patients with their close family members who do not have IBD to see what might be different.
SeoulAges 13–85 - NCT06172764RecruitingPhase 4
Vitamin D for early cavities: a saliva study
This study tests whether vitamin D supplements can help improve the health of your mouth by looking at changes in saliva and the bacteria that cause cavities. If you have early cavities and low vitamin D, you may be able to join.
Karachi, SindhAges 12–50 - NCT06190847Recruiting
Oral bacteria and response to chemoradiotherapy in esophageal cancer
This study looks at how the bacteria in your mouth might affect how well chemoradiotherapy (a combination of chemotherapy and radiation) works for esophageal cancer that cannot be removed by surgery. The goal is to see if the oral microbiome can predict treatment response.
Hefei, AnhuiAges 18–85 - NCT06699199RecruitingPhase 4
Testing silver diamine fluoride on mouth bacteria in kids
This study tests if a liquid medicine (silver diamine fluoride) painted on baby teeth cavities can change the bacteria in a child's mouth. It is for healthy children ages 4–10 with an open cavity.
Jeddah, Mecca RegionAges 4–12 - NCT07236125Recruiting
Nitrate-rich foods and mouth bacteria in children with high blood pressure
This study looks at how eating nitrate-rich vegetables (like spinach and beets) might affect the helpful bacteria in your child's mouth and their blood pressure. It's for children ages 10 to 18 who have primary hypertension (high blood pressure not caused by another condition) and are otherwise healthy.
Istanbul, FatihAges 10–18 - NCT07296965Recruiting
Oral bacteria in carotid artery plaque study
This study looks at the bacteria living in your mouth and whether they are linked to plaque buildup in the carotid artery (the main artery in your neck). If you are already scheduled for surgery to remove that plaque, the researchers will take samples from your mouth and the plaque to compare them.
BudapestAges 18 years+ - NCT07453212Enrolling by invitation
Food supplement for dry eye caused by meibomian gland issues
This trial tests a food supplement designed to improve dry eye symptoms by targeting the microbiome. It may help if you have dry eye due to meibomian gland problems and are not using contact lenses or certain other eye treatments.
IstanbulAges 18–65 - NCT04046900RecruitingPhase 1/Phase 2
Fecal-style transplant of vaginal microbiome for recurring BV
This trial tests whether transplanting “good bacteria” into the vagina can treat recurrent bacterial vaginosis (BV). It may help restore a healthier vaginal bacterial balance and reduce BV episodes.
Boston, MassachusettsAges 18–50 - NCT05412758Recruiting
Breath and blood tests to study stomach and food-pipe cancer
This study looks at how certain “volatile” substances in breath change in people with stomach or food-pipe (oesophageal) cancer, compared with people who have other non-cancer stomach/food-pipe conditions. It may help researchers find better, earlier ways to assess cancer—especially in people who have not started treatment yet.
LondonAges 18–90 - NCT06279065Recruiting
Gut bacteria and giant cell arteritis study
This trial looks at how the bacteria in your gut might affect giant cell arteritis, a condition that causes inflammation in blood vessels. It aims to help doctors better understand the disease.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT07676461Recruiting
Microbiome study in advanced cancer patients starting immunotherapy
This study looks at the bacteria in your mouth, gut, and tumors to see if they affect how well first-line immunotherapy works. It is for people with advanced stomach, colorectal, breast, cervical, or head-and-neck cancer.
Bogotá, Bogota D.C.Ages 18 years+ - NCT07439718Recruiting
Nutrition drink study for healthy adults
This study tests how a special nutritional drink affects the tiny organisms living in your small intestine. You will take the drink and provide stool samples to help researchers understand gut health.
LausanneAges 18–60 - NCT05598112RecruitingEarly Phase 1
Oral stool-based microbiome treatment for healthy aging
This early-stage study tests whether changing the gut bacteria using an oral stool-based treatment (called oral FMT) can improve health in older adults. It aims to see if this approach affects aging-related changes, including gut and body function.
Beijing, Beijing MunicipalityAges 70–85 - NCT07501455Recruiting
Studying toothpaste and mouth rinse effects on gum inflammation
This study tests whether using a certain toothpaste and mouth rinse can reduce gum inflammation (gingivitis) better than brushing alone. It is for people with mild to moderate gum disease who have not used tobacco or certain medications recently.
Somerville, MassachusettsAges 18–60 - NCT05852145RecruitingPhase 1/Phase 2
Testing sweet drinks effect on children’s mouth health
This early-stage study looks at how drinking soft drinks with and without sweeteners affects children’s mouths and teeth. It may help researchers understand which types of sweet drinks contribute to more tooth damage.
Mexico City, CuahutemocAges 12–18 - NCT05837221Recruiting
Study of the mouth microbiome in oral cancer
This study looks at the types of bacteria in the mouth (the microbiome) in people with oral squamous cell cancer and compares them to people without this cancer. It may help researchers understand what’s different in oral cancer and what could be useful for diagnosis or treatment planning.
Aurora, ColoradoAges 18–100
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Common questions
- Are there clinical trials for oral microbiome?
- Yes. Clin2 currently lists 25 recruiting oral microbiome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a oral microbiome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a oral microbiome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.