Clinical trials
Orthopedic Surgery clinical trials
Below are recruiting orthopedic surgery clinical trials, each written for real people, not researchers. We’re tracking 49 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06604364Recruiting
Virtual reality to reduce anxiety before children's arm or leg surgery
This study tests whether watching a virtual reality video can help calm children aged 7 to 12 before minor orthopedic surgery. If your child is having a short procedure (less than an hour) with a numbing shot instead of full sleep medicine, this might be a good fit.
BolognaAges 7–12 - NCT07342647Recruiting
Safer antibiotics for people with beta-lactam allergies in joint replacement surgery
This trial tests a better way to choose antibiotics during joint replacement surgery for patients who are allergic to beta-lactams (a common class of antibiotics). The goal is to prevent infections while avoiding allergic reactions.
StrasbourgAges 18 years+ - NCT07290504Recruiting
Tourniquet Release Methods for People with High Blood Pressure
This study tests two ways of releasing a tourniquet (a pressure cuff) after arm surgery to see which keeps blood pressure more stable in people with controlled high blood pressure. If you are having arm or hand surgery with a tourniquet, you may be able to join.
CairoAges 18–65 - NCT04109638Recruiting
PEMF therapy to reduce pain after shoulder or knee surgery
This trial studies whether PEMF, a type of non-surgical device that uses pulsed electromagnetic fields, can reduce pain after shoulder or knee surgery. If you join, you’ll also be expected to do post-surgery physical therapy exercises and report your pain and function.
Redwood City, CaliforniaAges 18 years+ - NCT07699601RecruitingPhase 2/Phase 3
Testing a pain tablet after orthopedic surgery
This trial tests an investigational tablet called HL-1186 for controlling pain after orthopedic surgery. It explores whether the drug can safely reduce moderate to severe pain when given after the procedure.
Changsha, HunanAges 18–75 - NCT05502380RecruitingPhase 3
Antibiotic prevention study for high-risk bone and spine surgeries
This Phase 3 study tests whether giving a broad set of preventive antibiotics before certain high-risk orthopedic surgeries lowers the chance of serious wound or bone infection. It mainly targets people who have contaminated wounds, tumor-related surgery, or known high-risk germs on the skin.
ZurichAges 18 years+ - NCT05899153Recruiting
Gait training with feedback for children with cerebral palsy
This trial tests whether walking practice with real-time feedback (“biofeedback”) can improve how people with cerebral palsy move their legs. It’s designed to help with safer, more efficient walking during treadmill training.
Saint Paul, MinnesotaAges 7–18 - NCT06320041RecruitingPhase 4
Oliceridine for pain after orthopedic surgery
This trial tests a new painkiller called oliceridine for moderate to severe pain after orthopedic surgery. It may help you recover more comfortably with fewer side effects.
Yiwu, ZhejiangAges 18–100 - NCT06341920Recruiting
BoneFit: exercise before hip or knee replacement
This trial tests a pre-surgery exercise program called BoneFit for people waiting at least 6 months for a hip or knee replacement. The goal is to see if getting stronger before surgery helps recovery.
HullAges 18–75 - NCT06467409RecruitingPhase 2
Study of LPM3480392 for pain after knee surgery
This trial tests an injection called LPM3480392 to see if it safely reduces moderate to severe pain after knee replacement or ligament repair surgery. It aims to help people who need strong pain relief after this type of surgery.
WuhanAges 18 years+ - NCT06664203Recruiting
Nerve block for arm surgery pain relief
This trial tests a special type of nerve block (called variable volume truncal block) for pain relief during arm, elbow, forearm, hand, or wrist surgery. It may help reduce pain and the need for strong pain medicines.
IstanbulAges 18–65 - NCT06818552Recruiting
Vascular surgeon's role in orthopedic tumor surgery
This trial is looking at how a vascular surgeon can help during surgery for tumors that involve blood vessels. It may help people with bone or soft tissue tumors that are close to or wrapped around major blood vessels.
Bologna, ItaliaAges 18 years+ - NCT07047469Recruiting
Ultrasound-guided spinal anesthesia in orthopedic surgery
This study compares two ways of giving spinal anesthesia (midline vs. paramedian) using ultrasound guidance in adults having orthopedic surgery. The goal is to see which approach is safer and more effective.
SohagAges 18–50 - NCT07353996RecruitingPhase 4
Finding the right dose of a new IV painkiller after bone surgery
This trial tests a single dose of a new pain medicine called tegileridine fumarate given through a vein right after orthopedic surgery (like spine, hip, or knee surgery). The goal is to find the best dose that works well for pain without causing side effects.
Hanzhong, ZhejiangAges 18–75 - NCT07392099Recruiting
Comparing a single pain relief class vs. usual care after orthopedic surgery
This study tests whether a single, 1-hour class on pain management (called Empowered Relief) can help people recover better after orthopedic surgery (like hip or knee replacement) compared to usual care. It is for people who have had moderate to severe pain for at least 3 months and are fluent in French.
Sherbrooke, QuebecAges 18 years+ - NCT07443085RecruitingPhase 2
Dexmedetomidine dose and delirium risk after orthopedic surgery
This trial tests different doses of a medicine called dexmedetomidine to see if it can reduce confusion (delirium) after major leg surgery in older adults. If you are 65 or older and planning to have hip or knee replacement surgery, you may be eligible.
Banhā, Al QalyobiaAges 55–70 - NCT07512752Recruiting
Preoperative Stress and Confusion After Orthopedic Surgery
This study examines how anxiety before major joint surgery (hip or knee) affects confusion and delirium after surgery in adults 65 and older. Understanding this connection may help doctors better manage patients' emotional and mental health around surgery.
ElâzığAges 65 years+ - NCT07657039Recruiting
Comparing climate impact of common orthopedic surgeries
This study looks at how much different hand and foot surgeries affect the environment. If you are having one of these procedures at Danderyd's Hospital, you may be able to help researchers learn which methods have a smaller climate footprint.
StockholmAges 18 years+ - NCT06854913Enrolling by invitation
Shoulder Surgery and Sleep in Workers
This study looks at how shoulder surgery affects the sleep of people who do physical work. If you are having shoulder surgery, researchers want to see if your sleep changes after the operation.
Rome, ItalyAges 18 years+ - NCT05112302Enrolling by invitation
Virtual reality during orthopedic anesthesia
This study tests whether using virtual reality during hip or knee surgery (while you’re receiving a nerve block for anesthesia) helps make the experience more comfortable. You’d try the VR during your procedure, and the team will compare outcomes with usual care.
Jackson, FloridaAges 18 years+ - NCT06179004RecruitingPhase 3
Numbing medicine comparison for wrist surgery pain
This study compares two types of numbing medicine (bupivacaine and liposomal bupivacaine) given near the collarbone before wrist surgery to see which provides better pain relief afterward.
Chapel Hill, North CarolinaAges 18 years+ - NCT06381791RecruitingPhase 1/Phase 2
CBD for pain after shoulder surgery
This study tests if CBD (a cannabis extract) can help manage pain after rotator cuff repair surgery. It aims to find a better way to control pain and reduce the need for stronger painkillers.
Houston, TexasAges 18 years+ - NCT05534724Recruiting
Compare early vs partial weight bearing after bunion surgery
This study compares whether it’s safer to put weight on your foot early versus only partly after bunion surgery. It may help your care team choose the best recovery plan for healing and comfort.
LuganoAges 18–85 - NCT06877078Recruiting
Podcast for constipation before surgery
This study tests if listening to a podcast about preventing constipation before surgery can help people who are having back, shoulder, knee, or hip surgery. If you are scheduled for one of these surgeries, you may be able to take part.
SilkeborgAges 18 years+
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Common questions
- Are there clinical trials for orthopedic surgery?
- Yes. Clin2 currently lists 49 recruiting orthopedic surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a orthopedic surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a orthopedic surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.