Clinical trials
Orthostatic Hypotension clinical trials
Below are recruiting orthostatic hypotension clinical trials, each written for real people, not researchers. We’re tracking 25 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT01370512Enrolling by invitationPhase 2
Droxidopa plus pyridostigmine for low blood pressure on standing
This Phase 2 study tests whether the medicines droxidopa and pyridostigmine can improve symptoms of orthostatic hypotension, which is low blood pressure when you stand up. It is designed for people whose low blood pressure is caused by problems with the nerves that control blood pressure.
Rochester, MinnesotaAges 18 years+ - NCT04782830Recruiting
Wearable sensor study for low blood pressure on standing
This study uses an accelerometer (a wearable motion sensor) to measure symptoms and blood pressure changes when you stand up. It may help doctors better track how neurogenic orthostatic hypotension affects you and how well current treatments are working.
Nashville, TennesseeAges 40–80 - NCT05295810Recruiting
Breathing test for people with low blood pressure on standing
This study checks how your body controls breathing and heart rate when you stand up, especially if you get dizzy from low blood pressure. It may help researchers understand what causes symptoms and how to improve testing for people with this condition.
Calgary, AlbertaAges 18–100 - NCT07089043RecruitingPhase 2
Study for people with dizziness when standing from Parkinson's or nerve failure
This study tests a new treatment for dizziness and low blood pressure when standing, caused by Parkinson's disease or pure autonomic failure. It may help if you already take medications like midodrine or droxidopa.
Scottsdale, ArizonaAges 18–85 - NCT06920134Recruiting
Spinal cord stimulation for blood pressure in Parkinson's disease
This trial tests if electrical stimulation of the spinal cord can help manage blood pressure drops (orthostatic hypotension) in people with Parkinson's and related conditions. It might make daily activities like standing and walking easier.
Lausanne, Canton of VaudAges 18–90 - NCT05731986Recruiting
Skin nerve stimulation to raise blood pressure after spinal injury
This study tests whether a device that delivers mild electrical stimulation through the skin can improve low blood pressure after an acute spinal cord injury. It may help reduce episodes of dizziness or faint-feeling caused by blood pressure dropping when you sit up.
West Orange, New JerseyAges 18–75 - NCT06831500RecruitingPhase 1/Phase 2
Study on carbidopa/levodopa ratio for low blood pressure in MSA-P and Parkinson's
This study tests whether adjusting the ratio of carbidopa and levodopa (medications used for Parkinson's) can help reduce dizziness or fainting from low blood pressure when standing up, in people with Multiple System Atrophy (Parkinsonian type) or Parkinson's disease.
Lausanne, Canton of VaudAges Any age - NCT05725499Recruiting
Check if skin stimulation lowers blood pressure drops after spinal injury
This study tests a skin “stimulation” treatment to see if it helps stabilize blood pressure in people with spinal cord injury who get low blood pressure when sitting up. If you often have dizziness, faintness, or low readings after changing positions, this trial may help find safer ways to manage it.
West Orange, New JerseyAges 18–75 - NCT07195903Recruiting
Stand-up study for dizziness when standing
This study tests a new approach to help people who feel dizzy or faint when standing up, especially if standard treatments haven't worked. It aims to improve daily life and reduce risks from low blood pressure.
Roslyn, New YorkAges 18 years+ - NCT05621460Recruiting
Water carbonation and how well you tolerate standing up
This study tests whether drinking carbonated (fizzy) water changes how well your body handles standing up without feeling faint. If you are healthy and don’t have certain heart or nerve problems, you may be able to take part.
Burnaby, British ColumbiaAges 19–50 - NCT05839652RecruitingPhase 4
Treatment for blood pressure drops after spinal cord injury
This Phase 4 trial studies a treatment to help people with spinal cord injuries who get orthostatic hypotension, meaning blood pressure drops when they change position. If you fit the specific injury and health criteria, the study may offer a structured way to improve symptoms and monitor safety.
West Orange, New JerseyAges 18–60 - NCT07579026Recruiting
Breathing exercises for pregnant women with POTS
This study tests whether special breathing exercises can help pregnant women with POTS (a condition where your heart races when you stand up). POTS causes dizziness, lightheadedness, and fainting, and this trial aims to see if breathing retraining makes these symptoms better during pregnancy.
Sialkot, Punjab ProvinceAges 19–35 - NCT07196397Recruiting
Polish Registry of Heart Nerve Procedures
This registry tracks people who have had or plan to have a procedure that changes the nerves controlling heart rate, such as cardioneuroablation. It aims to better understand and treat conditions like inappropriate tachycardia, POTS, and fainting spells.
RzeszówAges 18 years+ - NCT07502599Recruiting
Fainting detection and early warning in syncope study
This study tests a new way to detect and warn about fainting in people with certain types of syncope (temporary loss of consciousness). It may help those who have already had a specific fainting evaluation called an ARS assessment.
Rochester, MinnesotaAges 18 years+ - NCT05400174Recruiting
How blood pressure changes affect thinking and brain flow in Parkinson’s
This study measures how your blood pressure affects thinking skills and how blood flows in the brain in people with Parkinson’s. It may help researchers understand what blood-pressure changes could mean for cognition in Parkinson’s.
San Diego, CaliforniaAges 50 years+ - NCT04493372Recruiting
Testing how well nerves control the heart after spinal cord injury
This study looks at how well the body’s automatic nerve functions (like heart and blood pressure control) work after a traumatic spinal cord injury. The goal is to better understand preserved nerve function and autonomic (automatic body) control, which could help guide future treatments.
Rochester, MinnesotaAges 18–50 - NCT05369520Recruiting
Noninvasive spinal stimulation to improve bladder and autonomic function
This trial tests a noninvasive way to stimulate the spinal cord to help the body’s “automatic functions” (like bladder, bowel, and sexual function) after spinal cord injury. If you’ve had a stable, complete spinal cord injury for more than a year, you may be eligible to try this approach and help researchers evaluate recovery.
Vancouver, British ColumbiaAges 19–60 - NCT05489575Recruiting
CPAP machine for high blood pressure when lying down at night
This study tests whether using a CPAP breathing machine at night can lower high blood pressure that happens while you sleep. It targets people with nervous-system problems that affect blood pressure changes when standing.
Nashville, TennesseeAges 40–80 - NCT05908760Recruiting
Breathing carbon dioxide may help low blood pressure symptoms
This proof-of-concept pilot study tests whether a controlled breathing test that re-breathes carbon dioxide can improve symptoms or body responses in people with neurogenic orthostatic hypotension (a drop in blood pressure when standing). It may help researchers understand how the nervous system involved in blood pressure control works.
Calgary, AlbertaAges 18–100 - NCT06647641Recruiting
Genetics study for PSP, CBS, MSA, and related conditions
This study looks at genetic factors in people with PSP, CBS, MSA, or similar brain conditions, and also in their family members. It involves genetic testing to learn more about these diseases and may help find new treatments.
Boston, MassachusettsAges 35 years+ - NCT06714565Recruiting
Can blood pressure and brain oxygen predict falls?
This study looks at how measuring blood pressure and oxygen levels in the brain may help predict falls in older adults. If you have fallen before, your participation could help doctors find better ways to prevent future falls.
AmsterdamAges 65 years+ - NCT06841198Recruiting
Heart and blood vessel health after spinal cord injury
This study looks at how the heart and blood vessels change in the first year after a spinal cord injury. It also tests if electrical stimulation can help improve low blood pressure, which is common after injury.
West Orange, New JerseyAges 18–75 - NCT01799915Recruiting
Study of causes and progression of synuclein-related nerve conditions
This study follows people over time to better understand “synucleinopathies,” which are conditions that affect the nervous system as it develops and progresses. You may be asked to return for visits and report symptoms, especially those that happen when you stand up.
Boston, MassachusettsAges 18 years+ - NCT02897063RecruitingPhase 1
Test medicines for low blood pressure in nerve-related disorders
This early (Phase 1) study tests whether midodrine and droxidopa can improve blood-flow pooling in the belly in people with nerve problems that affect blood pressure when standing. It’s looking at safety and how the body responds, which may help reduce dizziness or fainting for some participants.
Nashville, TennesseeAges 40–80
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Orthostatic Hypotension trials by city
Studies with a site in or near these metro areas.
Orthostatic Hypotension trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for orthostatic hypotension?
- Yes. Clin2 currently lists 25 recruiting orthostatic hypotension studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a orthostatic hypotension trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a orthostatic hypotension trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.