Clinical trials
Parkinsonism clinical trials
Below are recruiting parkinsonism clinical trials, each written for real people, not researchers. We’re tracking 749 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05152394RecruitingPhase 1
Testing cord stem cell exosome treatment for Parkinson’s safety
This Phase 1 study tests whether a treatment made from donated umbilical cord “exosomes” is safe in people with Parkinson’s disease. It mainly looks at side effects and safety, and could help guide future treatments if it proves tolerable.
St John'sAges Any age - NCT05171205Recruiting
Spinal cord stimulation for people with parkinsonism symptoms
This trial studies whether spinal cord stimulation can improve symptoms in people with parkinsonism (Parkinson-like movement problems). It aims to see if the treatment is safe and helpful for the right patients.
Shanghai, Shanghai MunicipalityAges 50–80 - NCT05182892Recruiting
Reducing speech side effects from DBS using speech recordings
This study tests whether automated analysis of your speech can help reduce speech problems caused by deep brain stimulation (DBS) in Parkinson’s disease. It may help your team adjust DBS settings to improve how you speak while keeping Parkinson symptoms controlled.
PragueAges 18 years+ - NCT05205291Recruiting
Imaging inflammation in Parkinson’s using PET/MR scans
This study uses special brain scans (PET/MR) to see inflammation in people with Parkinson’s disease or related conditions. It may help researchers better understand what drives symptoms and how inflammation changes in the brain.
ExeterAges 50–85 - NCT05268887Recruiting
Light, sound, and touch therapy for Parkinson’s symptoms
This trial tests whether high-frequency light, sound, and gentle touch can improve movement and thinking problems in people with Parkinson’s disease. You may help the researchers learn if this kind of stimulation is safe and beneficial alongside your usual Parkinson’s medications.
Cambridge, MassachusettsAges 45–90 - NCT05307055Recruiting
Testing brain effects after low-frequency stimulation in Parkinson’s
This study looks at how Parkinson’s disease symptoms and brain thinking (neurocognitive function) may change after low-frequency stimulation from an implanted brain device. It may help researchers understand whether this specific stimulation pattern could improve thinking or brain-related symptoms.
Los Angeles, CaliforniaAges 18 years+ - NCT05347407Recruiting
Gut nerve cell biomarkers study for Parkinson’s risk
This trial studies nerve cell “biomarkers” from the gut to learn whether they can help detect Parkinson’s disease (or related conditions) earlier. You may be asked to undergo a colonoscopy to collect gut tissue for testing.
New York, New YorkAges 45–75 - NCT05348837Recruiting
Two-week sleep tracking for people with Parkinson’s
This study uses a wristband and a headband to track your sleep for two weeks. It’s meant to better understand sleep patterns in Parkinson’s, and may require temporarily changing your evening medication timing.
Aurora, ColoradoAges 18–80 - NCT05385315Recruiting
Blood test study to help detect Parkinson’s disease early
This study looks for a new blood marker that could help doctors detect Parkinson’s disease earlier. Depending on your diagnosis and treatment status, your blood may be compared with other people’s to see how well the test works.
GrenobleAges 18 years+ - NCT05400499Recruiting
Deep brain stimulation study in Parkinson’s visuomotor function
This trial studies how deep brain stimulation affects hand-eye (visuomotor) coordination in people with Parkinson’s. It may help researchers understand whether the stimulation settings change movement control for daily tasks.
Cleveland, OhioAges Any age - NCT05433441Recruiting
Parkinson care team program for people living at home
This study tests whether “Parkinson specialized teams” can improve care for people with Parkinson’s disease who live at home, with help from a main family caregiver. It looks at whether specialized support can be followed over time and whether it helps daily functioning.
BordeauxAges 18 years+ - NCT05444907Recruiting
Testing treatment response in DBS-related mania in Parkinson’s
This study is looking at people with Parkinson’s who developed mania (a high-energy mood episode) after deep brain stimulation (DBS) was turned on or its settings were changed. It may help doctors better understand why this happens and how to manage it safely.
LisbonAges 18 years+ - NCT05482126Recruiting
Studying brain sensing in advanced Parkinson’s during deep brain stimulation
This study looks at how the brain “filters” sensory information in people with advanced Parkinson’s disease, using brain imaging and deep brain stimulation (DBS) that you may already be getting as routine care. The goal is to better understand what drives Parkinson’s symptoms and how DBS might affect the brain.
Birmingham, AlabamaAges 18–89 - NCT05505019Recruiting
Using music to reduce apathy in Parkinson’s disease
This study tests whether music can help reduce apathy (low motivation) in people with Parkinson’s disease. It may help your mood and daily drive by targeting brain and behavior pathways tied to apathy.
Vancouver, British ColumbiaAges 40–85 - NCT05518617Recruiting
Imaging study for inherited Parkinson’s using PET, SPECT, and spinal fluid
This trial tests how well special brain scans (PET/SPECT) and spinal fluid tests can show changes in people with inherited (genetic) Parkinson’s. It may help researchers understand what’s happening in the brain and improve how these conditions are measured.
Exeter, DevonAges 25–80 - NCT05536388Recruiting
Study of a new drug for GBA-related Parkinson’s
This study is looking for ways to find new drugs that may help people with Parkinson’s caused by changes in the GBA gene. It may also include people with Gaucher disease and healthy volunteers, using blood and possibly skin samples.
New York, New YorkAges 18 years+ - NCT05539196Recruiting
Registry for Exablate treatment in Parkinson’s with medication problems
This trial is a real-world registry that follows people with Parkinson’s who are planning to get an Exablate 4000 procedure (a focused ultrasound treatment) for one-sided symptoms that are difficult to control with medication. It mainly checks outcomes and safety over time, helping doctors understand how well this treatment works in everyday care.
Baltimore, MarylandAges 30–99 - NCT05550714Recruiting
Choosing anesthesia type during deep brain stimulation for Parkinson’s
This study compares different anesthesia choices during deep brain stimulation surgery for Parkinson’s disease, using a technique that guides electrode placement. It may help your care team choose the safest and most comfortable anesthesia approach for surgery.
BeijingAges 50–80 - NCT05557864Recruiting
Brain scan study for Parkinson’s patients with deep brain stimulators
This study looks at how the location of a deep brain stimulator in Parkinson’s disease affects movement problems. It mainly uses advanced 7T brain imaging to compare brain activity and motor symptoms.
Minneapolis, MinnesotaAges 21–89 - NCT05576818RecruitingPhase 3
Synbiotic add-on for people with Parkinson’s disease
This trial tests whether adding a synbiotic (a mix of probiotics and prebiotics) along with standard Parkinson’s medicines can improve symptoms or health outcomes. It’s mainly for adults with Parkinson’s disease at earlier to mid-stages who take dopamine replacement therapy.
Tanta, El GharbiaAges 45–65 - NCT05603715RecruitingPhase 2
Pyridostigmine to help constipation in Parkinson’s
This trial tests whether pyridostigmine can improve constipation symptoms in people with Parkinson’s disease. If you have Parkinson’s and functional constipation (with infrequent bowel movements), this study may offer a new medication option and closely track your bowel function.
Burlington, VermontAges 18 years+ - NCT05626608Recruiting
Directional brain stimulation for Parkinson’s tremor and movement control
This trial tests a continuous electrical brain stimulation device placed in a deep brain area to help Parkinson’s symptoms—especially tremor and trouble with movement. It may help improve daily function and reduce periods when medicine does not work well.
Montpellier, FranceAges 18–70 - NCT05644327Recruiting
Exercise program to improve sleep in Parkinson’s disease
This study looks at whether an exercise program can improve sleep problems in people with Parkinson’s disease. It’s mainly for those who already have poor sleep quality while taking stable Parkinson’s medicine.
Laval, QuebecAges 40 years+ - NCT05658302Recruiting
Deep brain stimulation for Parkinson’s, using targeted stimulation
This study is testing a specific approach to deep brain stimulation (DBS) for people with Parkinson’s disease who are getting DBS surgery as part of routine care. It may help doctors learn whether circuit-based, more targeted stimulation is safe and useful for Parkinson’s symptoms.
Minneapolis, MinnesotaAges 21 years+
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Common questions
- Are there clinical trials for parkinsonism?
- Yes. Clin2 currently lists 749 recruiting parkinsonism studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a parkinsonism trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a parkinsonism trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.