Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 270 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07421960Recruiting
Periodontitis and sleep quality study
This study looks at how gum disease (periodontitis) might be related to sleep quality. It compares people with healthy gums to those with gum disease.
Istanbul, IstanbulAges 18–65 - NCT07282756Recruiting
Lovastatin gel for gum disease treatment
This study tests whether a lovastatin gel applied to the gums (after a deep cleaning) helps treat gum disease better than cleaning alone. Participants must not have had previous gum treatment or antibiotics recently, and can be a smoker or non-smoker.
Bielsko-Biala, Silesian VoivodeshipAges 18–59 - NCT07551115Recruiting
Oral Parasites and Gum Health Study
This study examines whether certain microscopic parasites in the mouth are linked to gum disease. Researchers will compare people with healthy gums to those with gum inflammation or disease to understand this connection better.
Bolu, GölköyAges 18 years+ - NCT07446127Recruiting
Adding Laser to Gum Disease Treatment
This trial tests adding a special laser (diode laser) to standard deep cleaning for gum disease. The goal is to see if the laser helps reduce infection and improve healing better than cleaning alone.
Afula, NorthAges 18 years+ - NCT07661784Recruiting
Saliva tests to track gum disease
This study looks at whether substances in your saliva can show if gum disease is getting worse. It might help find a simple way to monitor gum health without needles or X-rays.
IspartaAges 18–65 - NCT06967402Recruiting
Mouthwash study for gum disease treatment
This study tests two types of mouthwash to see which helps treat gum disease better when used with regular dental care. It may be a good option if you have moderate to severe gum disease and are generally healthy.
Hong KongAges 18 years+ - NCT07671274RecruitingEarly Phase 1
Comparing two ways to treat gum disease without surgery
This study compares a standard deep cleaning method with a newer, less invasive approach for treating advanced gum disease (periodontitis). It aims to see if one works better for patients with good oral hygiene and no other health issues.
Al Mansurah, DakhliaAges 20–40 - NCT07013682Recruiting
Platelet-rich fibrin combined with deep cleaning for gum disease
This trial tests if adding platelet-rich fibrin (a natural healing concentrate from your blood) to standard deep cleaning improves treatment for advanced gum disease. It may help patients with widespread gum disease who have not had treatment in the last year.
BernAges 18 years+ - NCT07707063RecruitingPhase 4
Gum disease treatment with I-PRF, iodine, or laser in smokers and non-smokers
This trial tests whether adding I-PRF (a concentrate from your own blood), povidone-iodine, or laser treatment to standard deep-cleaning helps smokers and non-smokers with gum disease. You may qualify if you have moderate to severe gum disease with at least one bleeding pocket in each area of your mouth.
Tunis, Mont FleuryAges 18 years+ - NCT05813236Recruiting
Compare two suture types for gum surgery healing
This trial compares two different types of stitches (suture materials) to see which one works better after gum (periodontal) surgery. It may help by improving comfort and healing in people needing resective periodontal surgery.
Sant Cugat del Vallès, CataloniaAges 18 years+ - NCT07327658Recruiting
Periodontal treatment and pocket depth changes
This trial looks at how much gum pocket depth decreases after standard gum disease treatment. It is for people with advanced periodontitis who are otherwise healthy.
Konya, KonyaAges 18–65 - NCT07312045Recruiting
Gum health and healing after non-surgical treatment
This study looks at how certain blood and saliva measurements relate to gum disease and healing after a deep cleaning. It may help find better ways to track gum health.
Merkez, ErzincanAges 18–65 - NCT06961409Recruiting
Saliva markers test for gum health
This trial measures certain proteins in your saliva to understand how they relate to different stages of gum disease. If you're generally healthy and have not smoked or taken certain medications recently, you may be able to join and help researchers learn more about gum health.
Izmir, ÇiğliAges 18–70 - NCT06958874Recruiting
Erythritol for gum pocket healing
This study tests if adding erythritol to standard gum treatment helps close deep gum pockets in people with advanced gum disease (periodontitis).
L’AquilaAges 35 years+ - NCT06798116Enrolling by invitation
Gum disease treatment with platelet-rich fibrin and albumin gel
This study tests a new treatment for severe gum disease. It combines a natural blood product (platelet-rich fibrin) with a special albumin gel to help repair bone defects around teeth. The goal is to see if this mixture helps the bone grow back better than standard treatment.
Al MansurahAges 25–55 - NCT06745141Recruiting
Gum disease treatment after a heart attack
This trial tests whether treating severe gum disease can improve recovery after a heart attack (STEMI). If you recently had a heart attack and also have serious gum problems, you may be able to join and receive periodontal care.
Shanghai, Shanghai MunicipalityAges 30 years+ - NCT06428149Recruiting
Comparing gum surgery techniques for deep pockets
This study looks at three different ways to make cuts in the gums during surgery for deep pockets caused by gum disease. It aims to find which technique helps heal better and save more bone.
Murcia, MurciaAges 18–80 - NCT07468929Recruiting
Blood proteins during gum disease treatment
This study looks at how inflammation-related proteins in the blood change during gum disease treatment done under IV sedation. It may help doctors understand how the body responds to treatment.
Columbus, OhioAges 21–75 - NCT07579338Enrolling by invitation
Bacteria and Gum Health: A Detection Study
This study examines specific bacteria in your mouth to understand their role in healthy gums versus gum disease. Researchers will collect samples to measure bacterial levels and help improve how gum disease is diagnosed and treated.
Hillah, BabelAges 30 years+ - NCT02833285Recruiting
Study immune cells in people with gum disease
This study looks at how the immune system (B cells) works in gum disease and may help doctors better understand the condition. You may be asked to take part if you need gum surgery and meet other health and treatment rules.
BrestAges 18–75 - NCT07549347Recruiting
Smart Toothbrush vs. Professional Cleaning for Gum Disease
This study tests whether using an intelligent (electric) toothbrush with a smartphone app can manage early gum inflammation as effectively as professional dental cleaning. If you have mild gum disease, this trial may help you avoid or delay professional treatments.
Shanghai, Shanghai MunicipalityAges 18–64 - NCT07406867Recruiting
Can photos and bitewings detect gum disease?
This study tests whether photos, X-rays, and other non-invasive methods can identify gum disease as accurately as a clinical exam. It may help patients avoid needles or probing.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05439330Recruiting
Dental MRI to help diagnose jaw, gum, and tooth problems
This study tests whether a special dental MRI can give useful pictures to diagnose jaw joint problems, tooth-related tissue changes, and gum/inflammation issues, and to help plan some dental implant treatments. If you need imaging for these reasons, the trial may help doctors choose the best next treatment by using clearer, dedicated scans.
AarhusAges 18 years+ - NCT06656325Recruiting
Laser treatment for gum disease study
This study tests a special low-level laser (Erchonia FX-405) as an extra treatment for gum disease (periodontitis). It aims to see if adding this laser to standard care helps improve gum health and reduce infection.
Thousand Oaks, CaliforniaAges 22–75
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 270 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.