Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 270 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07274189Recruiting
Gum health and sodium bicarbonate toothpaste study
This trial tests whether a sodium bicarbonate (baking soda) toothpaste can improve gum health compared to a standard toothpaste. If you have some gum problems (but not too severe), it might help.
PlymouthAges 18 years+ - NCT05439330Recruiting
Dental MRI to help diagnose jaw, gum, and tooth problems
This study tests whether a special dental MRI can give useful pictures to diagnose jaw joint problems, tooth-related tissue changes, and gum/inflammation issues, and to help plan some dental implant treatments. If you need imaging for these reasons, the trial may help doctors choose the best next treatment by using clearer, dedicated scans.
AarhusAges 18 years+ - NCT07233512Enrolling by invitation
Periodontal treatment for Alzheimer's disease
This trial tests whether treating gum disease can improve outcomes for people with Alzheimer's disease. If you have mild to moderate Alzheimer's and gum disease, you may be able to join.
LiègeAges Any age - NCT04719026Recruiting
Teeth and heart attack link in people with or without heart attacks
This study compares dental health in people who were recently admitted for a heart attack with similar people who have not had a heart attack. It aims to see whether gum and dental health might be related to heart attack risk.
AberdeenAges 20–90 - NCT07070453Recruiting
Light-activated therapy for gum disease treatment
This study tests whether adding a light-activated therapy (photodynamic therapy) to standard deep-cleaning can improve gum disease treatment. It is for adults with periodontitis who have not had recent gum treatment or taken certain medications.
Almada, Monte Da CaparicaAges 18 years+ - NCT06656325Recruiting
Laser treatment for gum disease study
This study tests a special low-level laser (Erchonia FX-405) as an extra treatment for gum disease (periodontitis). It aims to see if adding this laser to standard care helps improve gum health and reduce infection.
Thousand Oaks, CaliforniaAges 22–75 - NCT06726902Enrolling by invitation
Comparing air polishing powders for gum disease treatment
This trial tests whether different air polishing powders improve nonsurgical gum disease treatment in people with moderate to severe periodontitis. It aims to find a better way to clean below the gum line without surgery.
AlexandriaAges 30–65 - NCT06698718Recruiting
Gum color changes after treatment for gum disease
This study uses a special color-measuring tool to see how gum color changes after basic gum disease treatment. It may help find better ways to check if treatment is working.
Hangzhou, ZhejiangAges 18–65 - NCT06633640Enrolling by invitationEarly Phase 1
Algae bone graft for gum disease bone defects
This study tests a new bone graft material made from algae, used with a collagen membrane, to help repair bone damage caused by gum disease. It might be an option if you have a deep pocket in the bone around a tooth and are healthy enough for the procedure.
CairoAges 20–65 - NCT07636733Recruiting
Vitamin D for Gum and Bone Health in Periodontal Disease
This study tests whether vitamin D supplements can reduce inflammation and improve healing in people with gum disease, ranging from mild gingivitis to advanced periodontitis. Researchers will compare how vitamin D affects different stages of gum disease.
RizeAges 18–70 - NCT06587971Recruiting
Intensive gum treatment for aortic stenosis
This trial tests whether intensive gum disease treatment can improve health in people with aortic stenosis (a narrowed heart valve). If you have both gum disease and mild-to-moderate aortic stenosis, you may be able to join.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06514664Enrolling by invitation
Do probiotic toothpastes help gums and teeth?
This trial tests whether using a probiotic toothpaste can improve gum health in people with gum disease (periodontitis). It may help reduce inflammation and slow bone loss.
KütahyaAges 18–99 - NCT06486012Recruiting
Light therapy for gum disease in diabetic patients
This trial tests if regular use of antibacterial light therapy can help manage and prevent gum disease symptoms in people with diabetes. It may offer a simple, non-invasive way to improve oral health.
Tampere, PirkanmaaAges 18 years+ - NCT06262035Recruiting
Gum and implant disease tissue profile study
This study looks at the genetic and bacterial profiles in gum disease and implant infections. It might help find new ways to diagnose or treat these conditions.
StockholmAges 18 years+ - NCT07575347Recruiting
Gum Disease and Rare Kidney Disorders Study
This study explores whether people with certain rare kidney diseases or chronic kidney problems have more gum disease than others. Researchers will examine your teeth and gums to understand the connection and help improve care for people with kidney conditions.
BucharestAges 18 years+ - NCT06123000Recruiting
Comparing two surgeries for gum disease
This study compares two types of gum surgery for people with advanced gum disease. It's designed to see which method works better for treating deep gum pockets and saving bone.
Florence, FIAges 18 years+ - NCT06083649Recruiting
Dental education: AI vs. human counseling for gum disease
This trial compares two ways of teaching about dental care—AI-assisted education versus speaking with a counselor—to see which one helps people with gum disease better control plaque and improve treatment outcomes.
Kaohsiung CityAges 35–65 - NCT06070181Recruiting
Adding Emdogain to deep cleaning for gum disease
This trial tests whether adding a treatment called Emdogain to a standard deep cleaning helps heal gum pockets better than deep cleaning alone. Emdogain is a gel that helps gums and bone regrow, and it is applied during the cleaning.
Linköping, Region ÖstergötlandAges 18 years+ - NCT06012019Recruiting
Gum Disease and Inflammation Study
This study looks at gum disease (periodontitis and gingivitis) and inflammation using blood and dental samples. It may help researchers understand how inflammation affects gum health.
Ivry-sur-SeineAges 18 years+ - NCT07673185Recruiting
Omega-3 and low-dose aspirin for gum disease in smokers
This trial tests whether taking omega-3 supplements with low-dose aspirin can improve gum health in smokers with advanced gum disease (stage III periodontitis). It aims to see if this combination safely reduces gum pocket depth and tissue damage.
CairoAges 30–50 - NCT05339178Recruiting
Study of quality of life in gum disease patients on maintenance care
This study asks people with periodontitis (gum disease) who are in ongoing maintenance visits after their active treatment. It looks at how supportive periodontal therapy affects quality of life.
ViennaAges 18–130 - NCT04831060Recruiting
Study of inflammation in gum and implant disease
This trial studies people with advanced gum disease (periodontitis) or gum inflammation around dental implants (peri-implantitis), and compares them with people who have healthy gums. The goal is to understand inflammation and how it relates to these dental conditions.
Ivry-sur-SeineAges 18 years+ - NCT04567030Recruiting
AI tool to help improve gum treatment outcomes
This trial tests whether an artificial intelligence (AI) system can help plan and improve results of gum (periodontal) treatment. You may be a good match if you have diagnosed periodontal disease and enough healthy teeth.
Kaohsiung CityAges 35–65 - NCT04046237Recruiting
Treating gum disease to study heart artery inflammation after a heart attack
This study tests whether treating severe gum disease in people who recently had a heart attack can reduce inflammation in the artery plaque. It may help researchers understand if gum treatment could benefit heart health after a heart attack.
ParisAges 30–70
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 270 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.