Clinical trials · California
Persistent Atrial Fibrillation clinical trials in California
We’re tracking 24 recruiting persistent atrial fibrillation studies with a site in California — including Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07626411RecruitingPhase 3
Blood Thinner Study for Irregular Heartbeat
This study tests a new blood thinner to prevent strokes and blood clots in people with atrial fibrillation (a common heart rhythm problem). You may qualify if you have atrial fibrillation and at least one risk factor for stroke, or if you've never taken a blood thinner before.
Newport Beach, CaliforniaAges 18 years+ - NCT07523750Recruiting
Comparing two catheter treatments for persistent atrial fibrillation
This study compares two different catheters that use pulsed field ablation to treat a type of irregular heartbeat called persistent atrial fibrillation. The goal is to see which one works better and is safer.
Fountain Valley, CaliforniaAges 18–80 - NCT07527299Recruiting
Varipulse catheter study for persistent atrial fibrillation
This study tests a new catheter to treat persistent atrial fibrillation (a type of irregular heartbeat lasting more than 7 days but less than a year). It aims to isolate the pulmonary veins and superior vena cava to restore normal rhythm. Some participants may also receive a left atrial appendage occlusion device if needed.
Birmingham, AlabamaAges 18–80 - NCT03546374Recruiting
Stop a common heart rhythm with surgery add-on therapy
This study looks at whether an added heart device approach around the time of planned open-heart surgery can help treat non-paroxysmal atrial fibrillation (AF), a long-lasting irregular heartbeat. It may help lower ongoing AF burden in people who also need non-emergency heart surgery.
St. Helena, CaliforniaAges 18 years+ - NCT05366361Recruiting
Study of persistent atrial fibrillation during heart procedures
This study looks at what happens in the heart in people with persistent atrial fibrillation when they undergo an ablation or Maze surgery. It may help doctors better understand the condition and improve future care for people needing these procedures.
Stanford, CaliforniaAges 22–80 - NCT05371405Recruiting
Using computer learning to improve care for atrial fibrillation patients
This study uses machine learning (computer pattern-finding) to better understand atrial fibrillation and guide care around the time of an ablation procedure. It may help refine how doctors treat certain AF patients based on their heart patterns.
Stanford, CaliforniaAges 22–80 - NCT04088071Recruiting
Ablation for heart rhythm problems using a specific technology
This study looks at how well catheter ablation works for treating certain heart rhythm disorders (like atrial fibrillation or ventricular arrhythmias) using a specific brand of catheters. The aim is to gather real-world data to better understand the procedure's outcomes.
Los Angeles, CaliforniaAges 18 years+ - NCT06784466Recruiting
New ablation procedure for atrial fibrillation
This study is testing a new type of ablation procedure for atrial fibrillation (an irregular heart rhythm). It uses special energy to create scar tissue in the heart to block faulty electrical signals. If you have AF that isn’t controlled by medication, you may qualify.
San Diego, CaliforniaAges 18–80 - NCT06959121Recruiting
Treating AFib during open-heart surgery with a new device
This trial tests a new device used during open-heart surgery to treat atrial fibrillation (AFib) by delivering tiny, fast electrical pulses to the heart tissue. It is for people who are already having heart surgery and want to also treat their AFib at the same time.
St. Helena, CaliforniaAges 18–85 - NCT07298473Recruiting
Redo ablation for recurrent atrial fibrillation with Sphere-9 catheter
This trial tests a new catheter and system for people who have had one previous ablation for atrial fibrillation but still have symptoms. It aims to see if a repeat procedure can safely and effectively treat recurrent episodes.
La Jolla, CaliforniaAges 18 years+ - NCT06735534Recruiting
Repeat ablation for persistent atrial fibrillation with pulsed field
This trial tests a newer type of ablation (pulsed field ablation) for people with persistent atrial fibrillation who have already had one ablation. The goal is to see if it can fix the heart rhythm problem again.
Los Angeles, CaliforniaAges 18 years+ - NCT04404465Enrolling by invitation
Test blood/heart signals to understand atrial fibrillation changes
This study looks at early changes in the heart related to atrial fibrillation (AF) using health data and biomarkers. It aims to find better ways to predict or understand AF, especially around procedures like ablation or cardioversion.
San Francisco, CaliforniaAges 18 years+ - NCT06324201Recruiting
Long-term safety of a new ablation system for paroxysmal AF
This study tests a new system (QDOT MICRO and VISITAG SURPOINT) used during a catheter ablation procedure to treat atrial fibrillation (AF). It aims to see how safe and effective it is over the long term for people whose AF comes and goes and hasn't been controlled by medication.
Ventura, CaliforniaAges 18 years+ - NCT06455098Recruiting
Pulsed field ablation for paroxysmal atrial fibrillation
This study tests a new procedure called pulsed field ablation using a special catheter to treat paroxysmal atrial fibrillation (AF), a type of heart rhythm problem that comes and goes. It may be an option for people whose AF hasn't been controlled well with medication.
Burlingame, CaliforniaAges 18–80 - NCT06995391Recruiting
Alcohol reduction app for atrial fibrillation
This trial tests if a smartphone app can help people with atrial fibrillation reduce or stop drinking alcohol. The goal is to see if cutting down on alcohol makes AF symptoms less severe or occur less often.
San Francisco, CaliforniaAges 21 years+ - NCT04045665RecruitingPhase 3
Blood thinner vs usual care for new heart rhythm after bypass surgery
This trial tests whether using a blood thinner in people with new, temporary atrial fibrillation after CABG (heart bypass surgery) can reduce harmful outcomes compared with standard treatment. It may help prevent stroke or other complications if your rhythm problem fits the trial’s timing and risk profile.
Los Angeles, CaliforniaAges 18 years+ - NCT07405359Recruiting
Comparing ablation methods for persistent atrial fibrillation
This trial tests a newer, possibly safer way to treat persistent atrial fibrillation using pulsed field ablation. It compares standard vein isolation alone to adding extra ablation spots to improve success.
San Francisco, CaliforniaAges 18 years+ - NCT07227532Recruiting
Testing a new catheter for atrial fibrillation treatment
This study tests a new catheter system, called Varipulse, to see if it's safe and effective for treating atrial fibrillation (AF), a heart rhythm problem. People with short-lasting AF who haven't been helped by medication may be able to join.
Fountain Valley, CaliforniaAges 22 years+ - NCT07175428RecruitingPhase 2
Safety of a New Blood Thinner in AFib Patients
This study tests the safety of a new blood thinner for people with atrial fibrillation (AFib) who need long-term stroke prevention. If you qualify, the study will compare this medication to standard anticoagulation therapy.
Covina, CaliforniaAges 18 years+ - NCT07430956RecruitingPhase 3
Stroke prevention in atrial fibrillation without standard blood thinners
This trial tests a new medication to prevent strokes and blood clots in people with atrial fibrillation (an irregular heartbeat) who cannot safely take standard blood thinners. The drug works by blocking a different clotting factor, which may lower bleeding risks.
Huntington Beach, CaliforniaAges 18 years+ - NCT07278869Recruiting
Study of Append system for atrial fibrillation patients
This trial tests a new device, the Append System, to close off the left atrial appendage (a small pouch in the heart) in people with atrial fibrillation. The goal is to reduce stroke risk without needing long-term blood thinners.
Los Angeles, CaliforniaAges 18 years+ - NCT05963698Recruiting
Closing off a heart pouch to prevent stroke
This study tests a procedure that seals off the left atrial appendage (a small heart pouch) to help prevent stroke in people with atrial fibrillation. You may be considered if your stroke risk is high and you are already on blood-thinner medicine.
Pasadena, CaliforniaAges 18 years+ - NCT07308847Recruiting
Study of a new catheter system for treating atrial fibrillation
This trial tests a new catheter and mapping system designed to treat paroxysmal atrial fibrillation (AF), which is a type of irregular heartbeat that comes and goes. If you have this condition, the study aims to see how well the new system works with a minimally invasive procedure.
La Jolla, CaliforniaAges 18–80 - NCT03907046RecruitingPhase 3
Blood thinner study to prevent stroke after brain bleed
This Phase 3 study tests whether a blood thinner (apixaban) can help prevent another stroke and support recovery after you’ve had a brain bleed. You would be assigned to a treatment group, and the study checks safety and whether strokes can be reduced without causing dangerous bleeding.
Castro Valley, CaliforniaAges 18 years+
Persistent Atrial Fibrillation trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting persistent atrial fibrillation studies listed above.
- Stanford University · 6 studies
- Cedars-Sinai Medical Center · 4 studies
- Community Memorial Hospital · 3 studies
- Scripps Health · 3 studies
- University of California, San Francisco · 3 studies
- University of Southern California · 3 studies
- Adventist Health St Helena · 2 studies
- Cardiology Associates Medical Group · 2 studies
What taking part in a persistent atrial fibrillation study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Persistent Atrial Fibrillation trials in other states
Common questions
- Are there persistent atrial fibrillation clinical trials in California?
- Yes. We're currently tracking 24 recruiting persistent atrial fibrillation studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a persistent atrial fibrillation study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a persistent atrial fibrillation trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New persistent atrial fibrillation studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.