Clinical trials
Persistent Pain clinical trials
Below are recruiting persistent pain clinical trials, each written for real people, not researchers. We’re tracking 45 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06908486Recruiting
Cognitive training for pain in type 2 diabetes
This study tests a computer-based training program that may help people with type 2 diabetes and ongoing pain think about pain in a less negative way. You can do it from home on your computer over 3 months.
Camperdown, New South WalesAges 18 years+ - NCT06271174RecruitingPhase 3
Preventing long-term pain after child surgery
This study tests whether a pain block (medicine injected near nerves) can prevent long-term pain after a child's bone or joint surgery. It aims to help children have less pain months later.
NantesAges 5 years–15.3 years - NCT06621914Recruiting
Blood flow restriction training for military with leg injuries
This trial tests a low-weight exercise program using a special cuff on the leg (blood flow restriction) to see if it helps military personnel recover from leg injuries faster. It could be an option if pain is stopping you from doing normal rehab.
Loughborough, LeicestershireAges 18–55 - NCT06775535Recruiting
Spinal cord stimulation trial for chronic pain
This trial tests a closed-loop spinal cord stimulator that adjusts stimulation based on nerve signals. It may help people with chronic pain who are already scheduled to try this type of device.
RoeselareAges 18 years+ - NCT06949007Recruiting
Yoga for persistent pain after torso surgery
This study tests whether yoga or a health education program can help reduce long-term pain that started after a torso surgery like a chest, breast, or abdominal operation. You must have had surgery at least 3 months ago with moderate pain, and be able to attend classes in person or virtually.
Boston, MassachusettsAges 18 years+ - NCT05421273Recruiting
Testing two spinal stimulation patterns for long-term back pain
This study compares two ways of delivering spinal cord stimulation to see which better reduces pain in people with persistent spinal pain syndrome type 2. You would be assigned to one of the stimulation “burst” patterns and followed for changes in your pain experience.
Arnhem, GelderlandAges 18–70 - NCT07123233Recruiting
Cognitive behavioral treatment for chronic face and mouth pain
This trial tests a new cognitive-behavioral therapy (a type of talk therapy) for people with chronic orofacial pain – pain in the face, mouth, or jaw that has lasted for months. The goal is to learn skills to help manage pain and improve quality of life.
MilanAges 18–70 - NCT06351839Recruiting
Sleep better despite long-term pain
This trial tests a program to help people with chronic pain and insomnia sleep better. It focuses on combining pain management with sleep improvement strategies.
Tromsø, Troms CountyAges 18–75 - NCT07091123RecruitingPhase 4
Comparing two treatments for chronic back pain after surgery
This study compares two treatments for long-term back pain after surgery: a spinal cord stimulator (a device that sends mild electrical pulses to your spine) and a pump that delivers pain medicine directly to your spinal fluid. It will look at which treatment you prefer and how well it works over time.
Cleveland, OhioAges 30 years+ - NCT05861609Recruiting
Tapering pain meds for nerve pain after spinal cord stimulation
This study helps people with persistent nerve pain in the low back or legs who are planned to start spinal cord stimulation (SCS). It tests a careful plan to reduce (taper) opioid pain medicines using specific replacement medicines, while monitoring safety and pain control.
JetteAges 18 years+ - NCT05677412Recruiting
Studying sleep, stress, and pain in teens with ongoing pain
This study looks at how sleep and stress relate to pain that keeps coming back in teens. It may help researchers understand what could improve comfort and daily functioning when pain lasts more than three months.
HelsinkiAges 15–17 - NCT05407610Recruiting
Compare two types of nerve pain treatments for knee pain
This study compares conventional versus cooled radiofrequency treatments for long-lasting knee pain. It aims to see which method reduces pain better and helps patients function more comfortably.
AntwerpAges 18 years+ - NCT07141108Recruiting
Using a digital tool to track chronic pain and improve quality of life
This trial tests a digital tool that helps you track your pain and activity level. The goal is to see if using the tool can improve your quality of life. You would use a smartphone or tablet app and share updates with your primary care team.
Malmö, Skåne CountyAges 18 years+ - NCT05369130Recruiting
Predict pain after major aortic surgery
This study tries to understand and predict persistent pain after elective surgery on the thoraco-abdominal aorta (a major blood vessel in the chest and belly). The goal is to learn what factors may help patients have less long-lasting pain after surgery.
LondonAges 18 years+ - NCT06576219Enrolling by invitation
My Life is Music group therapy for teens with persistent pain
This study tests whether a group therapy program called 'My Life is Music' can help teenagers with ongoing pain. It looks at how well the program works and if it's a good fit for teens.
HelsinkiAges 13–17 - NCT06123715RecruitingPhase 2
Vitamin C to reduce pain after knee replacement
This study tests whether taking vitamin C before and after knee replacement surgery can reduce long-term pain. You may be eligible if you are having knee replacement for osteoarthritis and are generally healthy.
Toronto, OntarioAges 18 years+ - NCT07693270Recruiting
Study looking for markers of pain and opioid response after injury or surgery
This study is looking for biological markers (like blood tests) that can predict how people will respond to pain and opioids after a traumatic injury or surgery. The goal is to help doctors tailor pain treatment to each person.
La Jolla, CaliforniaAges 18 years+ - NCT06288282Recruiting
Predicting pain and opioid misuse in chronic back pain
This study looks at how thinking and behavior affect long-term pain and opioid use in people with chronic lower back pain. It aims to find better ways to manage pain and prevent medication misuse.
New York, New YorkAges 18 years+ - NCT05989230Recruiting
Emotional awareness therapy for pain after orthopedic injury
This trial tests a therapy that helps people understand and express their emotions to manage long-term pain after a serious bone injury. It may help if you have had pain most days for at least three months following surgery for an orthopedic injury.
Baltimore, MarylandAges 18 years+ - NCT06924671Recruiting
GLA:D Back Canada program for chronic low back pain
This study tests a program called GLA:D Back Canada, which is designed to help people with long-lasting low back pain. It focuses on exercises and education to improve your back health and daily function.
Edmonton, AlbertaAges 18 years+ - NCT06835868Recruiting
Registry for nerve stimulation treatments for chronic pain in Belgium
This trial creates a registry for people with chronic pain who are getting special nerve-modulating treatments in Belgium. It focuses on two specific chronic pain conditions: Persistent Spinal Pain Syndrome Type 2 (pain after spine surgery) and Complex Regional Pain Syndrome (a type of nerve pain).
Edegem, AntwerpAges Any age - NCT07110324Recruiting
Understanding long-term pain after hip or knee replacement
This study looks at people who still have moderate to severe pain months after a hip or knee replacement. The goal is to learn more about what causes this pain and how it feels, which could help improve future treatments.
Østerbro, København ØAges 18 years+ - NCT04874038RecruitingPhase 3
Lidocaine infusions to prevent long-lasting pain after breast surgery
This Phase 3 study tests whether receiving lidocaine through an IV during breast surgery can lower the chance of ongoing pain afterward. If it works, it may help some people avoid chronic, surgery-related pain in the chest wall, shoulder, or arm.
Calgary, AlbertaAges 18–100 - NCT06637709Recruiting
Pain after osteoarthritis treatment: a 24-month study
This study looks at why some people still have pain after knee surgery or other treatments for osteoarthritis. It tests a marker in the blood to see if it relates to ongoing pain. You would be followed for 24 months.
Roma, RomaAges 18–99
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Common questions
- Are there clinical trials for persistent pain?
- Yes. Clin2 currently lists 45 recruiting persistent pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a persistent pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a persistent pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.