Clinical trials
Persistent Pain clinical trials
Below are recruiting persistent pain clinical trials, each written for real people, not researchers. We’re tracking 45 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07763158Recruiting
Treatment for severe knee pain using artery embolization
This study tests a procedure that blocks tiny arteries in the knee to reduce pain from severe arthritis. It is for people who cannot have knee replacement surgery because of other health issues.
Jeddah, Mecca RegionAges 18 years+ - NCT06288256Recruiting
Spine surgery study: genes, thinking, and pain
This study is for people getting planned spine surgery. It looks at how your genes and thinking skills might affect your pain and use of pain medicine after surgery.
New York, New YorkAges 18 years+ - NCT06308029Recruiting
E-health pain self-management for breast cancer survivors
This trial tests an online program to help people manage lasting pain after breast cancer treatment. It's designed for those whose pain still gets in the way of daily life, even after finishing primary treatment.
AntwerpAges 18 years+ - NCT05941559Enrolling by invitation
EMDR therapy for long-term rheumatoid arthritis pain
This trial tests whether eye-movement therapy (EMDR) can reduce long-lasting pain in people with rheumatoid arthritis (RA). You may be eligible if your RA has been relatively stable, your pain is still high, and you can take part in therapy sessions safely.
Enschede, OverijsselAges 18 years+ - NCT07633730Recruiting
Nerve Block for Back Pain in Ankylosing Spondylitis
This study tests whether a nerve-blocking injection in the back muscles can relieve persistent back pain in people with ankylosing spondylitis (a condition causing spine inflammation and stiffness). The injection targets specific nerves to reduce pain while your current disease treatment continues.
Istanbul, PendikAges 18–65 - NCT07211308Recruiting
A study of spinal cord stimulation for chronic leg pain
This trial tests a type of spinal cord stimulation (DTM SCS) for people with chronic leg or foot pain caused by nerve damage (PSPS-T2). It aims to see if this treatment can safely reduce pain and improve daily life.
BrusselsAges Any age - NCT07413731Recruiting
Medication tapering with spinal cord stimulation
This trial tests how changing your pain medications while using a spinal cord stimulator affects your nervous system. It may help people with chronic lower back pain find the best way to manage their pain and reduce reliance on strong drugs.
WilrijkAges 18 years+ - NCT05068011Recruiting
Tested spinal cord stimulation for long-term severe back pain
This trial studies a targeted spinal cord stimulation therapy to reduce severe, long-lasting pain. It may help people whose pain is due to failed back surgery and who can safely use the implanted system.
Jette, Brussels CapitalAges 18 years+ - NCT05269212Recruiting
Help people with ongoing back pain return to work
This study looks at how to help people with long-lasting spinal pain (PSPS-Type II) get back to work. It may help by testing a plan for managing persistent pain so work becomes more doable.
GhentAges 18–60 - NCT07502612Recruiting
Spinal cord stimulation medication tapering study
This study tests whether lowering pain medication can improve how well spinal cord stimulation works. It is for people who already take certain pain medicines and are scheduled to try a spinal cord stimulator.
WilrijkAges 18 years+ - NCT06594796Recruiting
Lifestyle program for back pain and weight
This trial tests a combined exercise and lifestyle program for people with long-lasting low back pain who are overweight or have obesity. The program is delivered by physical therapists and aims to improve physical function and reduce pain.
AmsterdamAges 18 years+ - NCT06991205Recruiting
Web mind-body program for pain and substance use
This trial tests a web-based mind-body program to help people who have ongoing arm or hand pain and also use substances like alcohol or cannabis. It aims to improve resilience and reduce pain without requiring in-person visits.
Boston, MassachusettsAges 18 years+ - NCT06354699Recruiting
Pain after surgery in children: a long-term study
This study looks at children who have certain types of surgery to understand who might have ongoing pain, what causes it, and how it affects them over time.
San Francisco, CaliforniaAges Up to 16 years - NCT06182059Recruiting
Pain after knee replacement study
This study looks at long-term pain after total knee replacement surgery. It may help understand why some people have persistent pain and find ways to prevent it.
Monza, Monza BrianzaAges 18–85 - NCT05146778Recruiting
Opioid-free anesthesia to reduce long-term post-mastectomy pain
This study tests whether a pain-control approach without opioids (strong pain medicines) can lower persistent pain after mastectomy. It may help people avoid long-term pain and opioid side effects.
SeoulAges 19–80 - NCT06785909Recruiting
Understanding why pregnancy back and pelvic pain persists
This study looks at why some women develop ongoing pain in the lower back or pelvis during pregnancy. It tests how your body's sense of movement, fear of pain, and inflammation might be related. You may join if you are early in a single pregnancy and do not have that pain yet.
HasseltAges 18–40 - NCT06926322Enrolling by invitation
Treating dead baby molars with special medicines
This study tests different medicines to treat dead (necrotic) baby molars in children. The goal is to safely clean the infection and save the tooth so it can stay until it falls out naturally.
CairoAges 4–8 - NCT07453576Recruiting
Comparing bleach strengths for root canal retreatment pain
This trial tests if different concentrations of sodium hypochlorite (a disinfectant used in root canals) affect pain and certain natural chemicals in the tooth during root canal retreatment. It may help find the best option to reduce discomfort.
Erzurum, ErzurumAges 18–65 - NCT06593977Recruiting
Dynavisc gel for pain after repeat carpal tunnel surgery
This trial tests a gel called Dynavisc to see if it reduces pain when placed in the wrist during a second surgery for carpal tunnel syndrome. It may help people who still have pain after their first surgery.
Leuven, BelgiumAges 18–65 - NCT07672015RecruitingPhase 4
Testing a new pain drug in surgery patients at risk for opioid dependence
This trial tests a new painkiller called suzetrigine for post-surgery pain. It's designed for people whose medical records suggest they may have a higher chance of needing strong painkillers (opioids) long after surgery. We want to see if suzetrigine works better at preventing that.
La Jolla, CaliforniaAges 18 years+ - NCT07071350RecruitingPhase 2/Phase 3
Optimizing heart rate for persistent concussion symptoms in military veterans
This trial tests a treatment designed to improve heart rate variability, which may help reduce long-term concussion symptoms like headaches, dizziness, and trouble sleeping. It is for military veterans who have had a mild concussion more than a year ago and still have ongoing symptoms.
Richmond, VirginiaAges 18 years+
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Common questions
- Are there clinical trials for persistent pain?
- Yes. Clin2 currently lists 45 recruiting persistent pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a persistent pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a persistent pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.