Clinical trials
Photodynamic Therapy clinical trials
Below are recruiting photodynamic therapy clinical trials, each written for real people, not researchers. We’re tracking 43 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06445699Recruiting
Light therapy for hard-to-heal wounds
This trial tests a light-based treatment (photodynamic therapy) combined with a special gel dressing for chronic wounds that haven't healed after at least 3 months of standard care. It may help close the wound and reduce infection.
Chongqing, Chongqing MunicipalityAges 18–70 - NCT06834087Enrolling by invitation
Laser and dye vs. nanoparticle therapy for dark gums
This trial compares two newer treatments for dark gums—laser plus a blue dye versus laser plus tiny particles that are activated by light. The goal is to see which works better and is safer.
Kafr ash Shaykh, Kafr Ash Shaikh/ ElhamrawyAges 18–50 - NCT05973097Recruiting
Oral lichen planus treatment with herbal drug and light therapy
This trial tests whether an herbal medicine (paeoniflorin) combined with photodynamic therapy (a light-based treatment) can treat oral lichen planus. You may be considered if you’re an adult with oral lichen planus and can safely take part in the study.
BeijingAges 18 years+ - NCT07316023RecruitingPhase 2
Light therapy for gum disease treatment
This trial tests a new light treatment for gum disease using a special dye that targets and kills harmful bacteria. It may help if you have advanced gum disease and haven't had treatment recently.
CairoAges 36–50 - NCT06437288Enrolling by invitationPhase 4
Light-activated drug therapy for returning esophageal cancer
This trial tests a treatment called hematoporphyrin photodynamic therapy (a light-activated drug) for people with esophageal cancer that has come back or not fully gone away after prior treatment. It aims to see if this therapy can safely destroy remaining cancer cells in the inner layers of the esophagus.
Guangzhou, GuangdongAges 18–80 - NCT05688904RecruitingPhase 1
Topical imipramine with light treatment for skin pain relief
This Phase 1 study tests whether applying imipramine cream to the skin affects pain and effectiveness when combined with a light-based skin treatment (photodynamic therapy). It’s mainly looking at safety and early signs of benefit for people with certain sun-damaged skin areas.
Fairborn, OhioAges 18 years+ - NCT06306638RecruitingPhase 1/Phase 2
Light therapy after radiation for inoperable airway tumors
This trial tests a new light-activated therapy (interstitial photodynamic therapy) after palliative radiation to shrink inoperable airway tumors and improve breathing. It is for people with solid cancers that block the airway from the outside and cannot be removed with surgery.
Buffalo, New YorkAges 18 years+ - NCT06073704Recruiting
Light therapy for gum disease in people with obesity
This study tests whether adding a special light-activated cleaning (antimicrobial photodynamic therapy) to standard gum disease treatment can help people with obesity who have gum disease. It aims to see if this extra step improves gum health more than standard treatment alone.
Bauru, São PauloAges 18–70 - NCT07376824RecruitingPhase 3
Acupoint light therapy and Chinese medicine for ovarian reserve
This trial tests whether combining acupoint photodynamic therapy with traditional Chinese medicine can improve ovarian reserve in women with diminished ovarian reserve. It aims to find a gentle, non-hormonal way to support fertility.
Beijing, Beijing MunicipalityAges 25–40 - NCT06311890RecruitingPhase 2
Light therapy for moderate to severe acne
This trial tests a light-activated therapy (called photodynamic therapy) using a special gel that is put on the skin and then activated with a light to treat moderate to severe acne. It may help people who have not responded well to other treatments.
BeijingAges 18–50 - NCT06807359RecruitingPhase 1/Phase 2
Light-activated therapy for localized prostate cancer
This trial uses a special light-activated drug (photodynamic therapy) to treat prostate cancer that is still confined to the prostate. It aims to destroy the cancer while sparing healthy tissue, and may be an option for people with intermediate-risk prostate cancer who have not had other treatments.
New York, New YorkAges 18 years+ - NCT07241585Recruiting
Vitamin D and light therapy for skin cancer
This trial tests whether taking vitamin D before a special light therapy (photodynamic therapy) can help your body fight nonmelanoma skin cancers like basal or squamous cell cancer. You may join if you are scheduled for surgery to remove a skin tumor.
Cleveland, OhioAges 18 years+ - NCT07463859Recruiting
Treating gum disease and bad breath in diabetes patients
This trial tests whether combining standard gum treatment with a light-activated therapy can reduce bad breath in people with type 2 diabetes and advanced gum disease.
Bauru, São PauloAges 18–70 - NCT07368699Recruiting
Gum disease treatment with oxygen gel and light therapy
This trial tests a new gel that releases oxygen combined with a special light treatment to help heal advanced gum disease. It might help if standard treatments haven't been enough.
Alexandria, Bab SharqAges 30–70 - NCT07278999Recruiting
Light therapy and clobetasol for oral lichen planus
This trial tests two light-based treatments (photobiomodulation and photodynamic therapy) and a steroid cream (clobetasol) for painful oral lichen planus. The goal is to see which treatment works best to reduce mouth sores and discomfort.
Zabrze, Silesian VoivodeshipAges 20–70 - NCT06859866Recruiting
Light therapy for gum disease around dental implants
This trial tests whether a special light treatment (photodynamic therapy) you can use at home can help reduce inflammation around dental implants (peri-implant mucositis). It's designed for people with early gum problems around implants, before they get worse.
RomaAges 18 years+ - NCT06052033Recruiting
Light therapy vs. laser for persistent cervical changes with HPV
This study compares two treatments—photodynamic therapy using a special light-activated cream and a CO2 laser—to see which works better for clearing low-grade cervical changes caused by a long-lasting high-risk HPV infection. The goal is to find a safe, effective option for women who have had this condition for over a year.
Wenzhou, ZhejiangAges 18–65 - NCT07191522Recruiting
Light therapy for gum disease around dental implants
This trial tests if a special light treatment (photodynamic therapy) can help treat infection and inflammation around dental implants without surgery. It may be an option for people with mild to moderate peri-implantitis who don't smoke and have healthy gums otherwise.
Almada, Monte Da CaparicaAges 18 years+ - NCT06307548RecruitingPhase 1/Phase 2
Image-guided surgery and light therapy for colorectal cancer
This trial tests a special dye that helps surgeons see tumors more clearly during surgery, followed by a light therapy to destroy any remaining cancer cells. It is for people with advanced or returning colorectal cancer who are already scheduled for surgery.
Buffalo, New YorkAges 18 years+ - NCT06778434RecruitingPhase 2
Using a cream to improve light therapy for veterans' sun-damaged skin
This trial tests whether adding a cream called imipramine to standard photodynamic therapy (light treatment) can reduce the immune suppression that sometimes happens after the therapy. It may help veterans with sun-damaged skin on their forearms or face.
Dayton, OhioAges 18 years+ - NCT07381972RecruitingPhase 3
Light and sound therapy for nodular skin cancer
This trial tests a new treatment that combines light (photodynamic therapy) and sound (sonodynamic therapy) to treat a common type of skin cancer called nodular basal cell carcinoma. The goal is to see if this combination works better than light alone for small tumors.
Jaú, São PauloAges 18 years+ - NCT01898416RecruitingPhase 2
5-ALA by mouth to reduce regrowth of desmoid tumors
This Phase 2 trial tests whether taking a medicine called 5-ALA by mouth after treatment can lower how often desmoid tumors come back in the same area. If you have a desmoid tumor that can be removed and you meet safety criteria, this study may help determine whether 5-ALA is effective and safe for you.
Tel Aviv, IsraelAges 18 years+ - NCT06731881Recruiting
Light therapy to prevent infections after sinus or nose surgery
This study tests if a special light therapy can help prevent infections after sinus or nose surgeries. The treatment is given in addition to standard care and might lower the chance of needing more antibiotics.
London, LondonAges 16 years+ - NCT07729579RecruitingPhase 1
Study of a drug for actinic keratosis on arms or face
This trial tests how a new drug works in people with actinic keratosis (rough, scaly patches caused by sun damage) on their upper arms or face. You will receive the treatment and have blood samples taken to see how your body processes the medication.
College Station, TexasAges 18–85
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Common questions
- Are there clinical trials for photodynamic therapy?
- Yes. Clin2 currently lists 43 recruiting photodynamic therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a photodynamic therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a photodynamic therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.