Clinical trials
Placebo - Control clinical trials
Below are recruiting placebo - control clinical trials, each written for real people, not researchers. We’re tracking 3,902 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05077579Recruiting
Alzheimer’s scan study for people with higher body weight
This study uses brain scans (MRI and two special PET scans) to see how Alzheimer’s-related changes show up in people who are overweight or obese, with different blood-sugar and insulin patterns. It may help researchers understand whether body weight and metabolism affect early Alzheimer’s markers in the brain.
St Louis, MissouriAges 40–60 - NCT05098704RecruitingPhase 2/Phase 3
Clopidogrel to help prevent systemic sclerosis in high-risk people
This study tests whether the medicine clopidogrel can lower the chance of developing systemic sclerosis in adults who have certain blood antibodies and symptoms that suggest higher risk. If you qualify, you would take clopidogrel for the study to see whether it delays or prevents the disease.
BayonneAges 18–85 - NCT05104983RecruitingPhase 2
Sirolimus to prevent first seizures in babies with TSC
This Phase 2 study tests whether sirolimus (a targeted medicine) can stop or slow the start of seizures in very young babies diagnosed with tuberous sclerosis complex (TSC). If seizures are prevented early, it may also help protect early brain development.
Birmingham, AlabamaAges 1 day–6 months - NCT05079763Recruiting
Hydrogel treatment to reduce skin damage after breast radiation
This trial tests a bacterial cellulose–based gel with a soothing ingredient (monolaurin) to help prevent or lessen painful skin reactions in the area receiving breast radiation. It focuses on people who have already finished surgery and chemotherapy and are about to start a planned radiation treatment schedule.
ManilaAges 18–80 - NCT05133804RecruitingPhase 2
Testing two medications for PTSD attention and emotions
This Phase 2 study tests whether reboxetine or methylphenidate can improve attention and emotional or sensory problems in adults with post-traumatic stress disorder (PTSD). You may be eligible if you have a confirmed PTSD diagnosis and are able to meet medication and safety requirements.
AfulaAges 20–60 - NCT05097976RecruitingPhase 4
Medrol tablets to reduce pain after knee replacement
This trial tests whether a short course of Medrol (methylprednisolone) can improve recovery after outpatient total knee replacement done for osteoarthritis. You would be randomly assigned to receive Medrol or a comparison treatment.
Oak Brook, IllinoisAges 18 years+ - NCT05114096RecruitingPhase 4
One-time steroid shot to help babies stay healthier early
This trial studies whether giving a single steroid medicine shot during pregnancy can improve outcomes when preterm birth is at risk. The goal is to help the baby’s lungs and overall health before early delivery.
Calgary, AlbertaAges 18–55 - NCT05075161RecruitingPhase 3
Pirfenidone to help prevent lung scarring in ARDS
This Phase 3 trial tests whether pirfenidone can prevent or reduce lung scarring (fibrosis) in adults with ARDS who are within about a week of their illness starting. It may help by lowering harmful inflammation and the body’s scarring response.
Milan, MIAges 18 years+ - NCT05072314RecruitingPhase 3
Lidocaine drip after breast surgery to improve long-term pain
This Phase 3 study tests whether a long-running lidocaine (a numbing medicine) drip given around the time of breast surgery can improve long-term post-surgery pain and recovery. It may help people who have pain after mastectomy or breast-conserving surgery.
Kingswood, New South WalesAges 18 years+ - NCT05097365Enrolling by invitation
Testing a methyl-donor supplement to study lupus metabolism
This study looks at whether a “methyl-donor” nutrient supplement changes metabolism (methylation) in people with lupus who are also in the childbearing age range and have low-to-moderate disease activity. It may help researchers understand why lupus acts differently in some people and how diet-related pathways could affect symptoms.
São PauloAges 18–45 - NCT05067387RecruitingPhase 1
Oral THC and CBD for occasional cannabis users
This early (Phase 1) study tests how an oral THC and CBD product affects the body in healthy adults who use cannabis only rarely. It may help researchers understand safety and effects before larger studies.
Los Angeles, CaliforniaAges 21–55 - NCT05106608Recruiting
Mobile plus light therapy for dry mouth after head and neck cancer
This study tests whether “photobiomodulation” light therapy, guided by a phone app, can improve chronic dry mouth (xerostomia) in people who finished radiation for head and neck cancer. It may help reduce bothersome mouth dryness and support better day-to-day comfort after treatment.
GranadaAges 18 years+ - NCT05080569RecruitingPhase 4
Extra support after IUI for couples with unclear infertility
This study tests whether adding support in the period after ovulation (the “luteal phase”) helps people who are starting IUI (intrauterine insemination) because their infertility is unexplained. It’s designed to see if the added care improves chances when mild ovarian stimulation is used.
UtrechtAges 18 years+ - NCT04356755RecruitingPhase 2
Injections under the skin to heal scleroderma finger ulcers
This Phase 2 study tests whether injections under the skin can help heal painful, poor-circulation (ischemic) finger ulcers caused by scleroderma. It is for people whose ulcers have not improved with usual care.
GrenobleAges 18 years+ - NCT05052541RecruitingPhase 3
Oral cannabis for long-term spine pain
This trial studies whether taking cannabis by mouth can safely reduce chronic spine pain and improve daily comfort. You may be eligible if you have long-lasting spine pain and can follow study rules about stopping or limiting other cannabis and certain other treatments.
Aurora, ColoradoAges 21–84 - NCT05004987RecruitingPhase 4
Study brain and blood changes in older adults with depression
This study looks at how a brain protein linked to Alzheimer’s disease changes over time in older adults who have major depression but no major memory problems. It involves brain scans, blood and urine tests, and a spinal fluid sample to better understand the connection between depression and brain aging.
New York, New YorkAges 60 years+ - NCT05057806RecruitingEarly Phase 1
Testing how ketones may affect heart benefits in type 2 diabetes
This early study looks at people with type 2 diabetes and certain types of heart failure to see whether changes in “ketones” relate to heart benefits. It may help researchers understand who could benefit most from treatment-related metabolism changes.
San Antonio, TexasAges 18–80 - NCT05058287RecruitingPhase 3
Steroid shot during low-back surgery
This trial tests whether using a steroid medicine (a steroid shot) around the time of low-back decompression surgery improves pain and recovery. It is for adults having a limited-area laminectomy, and it compares steroid use versus not using it.
New York, New YorkAges 18–85 - NCT05011266RecruitingPhase 2/Phase 3
Buprenorphine plus naltrexone shot to prevent opioid relapse
This trial tests whether a combination of buprenorphine (through your care plan) and a monthly extended-release naltrexone (XR-NTX) shot can help prevent opioid relapse. It may help people who are ready to move toward a naltrexone-based relapse-prevention treatment after detox.
Rockville, MarylandAges 18–65 - NCT05052853RecruitingPhase 2
Early treatment trial for early schizophrenia warning signs
This Phase 2 study tests an NMDA-enhancer medicine to see if it can help people who are in the early “prodromal” stage—when symptoms are starting but full schizophrenia is not diagnosed yet. It aims to reduce or prevent worsening symptoms over the study period.
TaichungAges 13–45 - NCT05051436RecruitingPhase 4
Testing mirabegron and tadalafil to improve sugar control
This study looks at whether mirabegron and tadalafil can improve blood sugar control in people with prediabetes. It may help determine if these medicines can slow the move from prediabetes toward diabetes.
Lexington, KentuckyAges 35–65 - NCT05063149RecruitingPhase 3
Bacterial lysate for preventing breathing infections in preterm infants
This study tests a medicine called a bacterial lysate, which might help prevent respiratory infections and wheezing in babies born early. It could reduce sickness and breathing problems in the first year of life.
Rotterdam, South HollandAges 1 month–2 months - NCT05004727RecruitingPhase 4
Study for a psoriasis medicine in adults
This trial studies how guselkumab works for people with long-lasting, more severe psoriasis and signs that may affect joints. It may help by improving psoriasis symptoms and possibly reducing related inflammation, while researchers track safety and outcomes.
Boston, MassachusettsAges 18 years+ - NCT05058612RecruitingPhase 4
Midodrine to reduce drip medicines in ICU patients
This trial studies whether midodrine can help some ICU patients need less (or stop) a blood-pressure “drip” called vasopressors earlier. It’s meant to see if starting midodrine sooner can speed recovery and reduce how long you need these medicines.
Edmonton, AlbertaAges 18 years+
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Common questions
- Are there clinical trials for placebo - control?
- Yes. Clin2 currently lists 3,902 recruiting placebo - control studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a placebo - control trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a placebo - control trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.