Clinical trials
Postoperative Pain clinical trials
Below are recruiting postoperative pain clinical trials, each written for real people, not researchers. We’re tracking 560 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07353996RecruitingPhase 4
Finding the right dose of a new IV painkiller after bone surgery
This trial tests a single dose of a new pain medicine called tegileridine fumarate given through a vein right after orthopedic surgery (like spine, hip, or knee surgery). The goal is to find the best dose that works well for pain without causing side effects.
Hanzhong, ZhejiangAges 18–75 - NCT07432711Recruiting
Liposomal bupivacaine for pain after lung surgery
This trial tests if a long-acting numbing medicine called liposomal bupivacaine can reduce pain after video-assisted lung surgery. It aims to help patients feel better after the procedure with less need for other painkillers.
Beijing, Beijing MunicipalityAges 18–64 - NCT07441902Recruiting
Numbing medicine for lung surgery pain relief
This trial tests whether a numbing medicine (liposomal bupivacaine) injected near the ribs can reduce pain after lung surgery. If you qualify, you may experience less pain and need fewer painkillers after your operation.
Beijing, Beijing MunicipalityAges 18–64 - NCT07360028Recruiting
Nerve blocks for pain after chest surgery
This trial tests two types of numbing injections (nerve blocks) to control pain after chest surgery done with a camera. It aims to find which block works better so you can recover more comfortably.
Cairo, Abbassia-EgyptAges 25–70 - NCT06471348Recruiting
Pain control after scoliosis surgery: comparing two numbing medicines
This study compares two types of numbing medicine used during scoliosis surgery to see which provides better pain relief after the operation. One is a long-acting version (liposomal bupivacaine) and the other is a standard short-acting mix (bupivacaine with epinephrine). If you are a teen having surgery for Adolescent Idiopathic Scoliosis, this trial may help find a way to reduce pain and possibly lessen the need for opioids afterward.
Boston, MassachusettsAges 10–17 - NCT07041736Recruiting
Laser combo for pain and infection after root canal
This trial tests if using ultrasound and a 980 nm diode laser together can reduce pain and kill bacteria better after a root canal. It may help if you have a tooth with an infection at the tip, but no symptoms.
CairoAges 20–35 - NCT07134660Recruiting
Comparing two numbing medicines for lung surgery pain
This study compares two types of numbing medicine (liposomal vs. hydrochloride bupivacaine) injected near the ribs during lung surgery. The goal is to see which one provides better pain relief after the operation.
ShanghaiAges 18–80 - NCT06909851Recruiting
Comparing nerve blocks for pain after knee arthroscopy
This study compares two different types of nerve blocks to see which provides better pain relief after arthroscopic knee surgery. You will receive one of the blocks after your surgery, and your pain levels will be tracked.
IstanbulAges 18–72 - NCT07057557Recruiting
Aloe vera vs paraffin dressing for skin graft pain
This trial compares aloe vera dressing with paraffin tulle dressing to see which one reduces pain better at the area where a skin graft was taken. If you need a skin graft and are not allergic to either dressing, this study may help find a gentler way to manage your pain.
Lahore, Punjab ProvinceAges 18–60 - NCT06484192Enrolling by invitationPhase 4
Pain control after lower back fusion surgery
This trial tests a new pain management plan for people having spinal fusion surgery on their lower back. It aims to find the best way to control pain while reducing side effects.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06387303RecruitingEarly Phase 1
Comparing IV Methadone vs Spinal Morphine for Pain After Abdominal Surgery
This study compares two strong painkillers—methadone given through an IV versus morphine injected into the spine—to see which provides better pain relief and recovery after major abdominal surgery. It may help you if you're having open surgery and want less pain afterward.
Charlottesville, VirginiaAges 18–75 - NCT06456268Recruiting
VibraCool to reduce pain and opioid use after ACL surgery
This trial tests a device called VibraCool to see if it can reduce pain and the need for opioid painkillers after ACL reconstruction surgery.
New York, New YorkAges Any age - NCT06189781RecruitingPhase 4
Pain shot vs epidural for hip surgery in kids with cerebral palsy
This study compares a pain injection to epidural anesthesia for children with cerebral palsy having hip surgery. The goal is to see which method provides better pain control during and after the procedure.
Los Angeles, CaliforniaAges Up to 18 years - NCT07461467Recruiting
Managing breathing tube pressure to reduce throat problems in older adults
This study tests a way of managing the air pressure in a breathing tube mask used during surgery. The goal is to reduce throat and voice box problems after surgery in older patients.
Chongqing, Chongqing MunicipalityAges 60 years+ - NCT06535269Recruiting
Pain after hemorrhoid surgery: standard vs bipolar sealer
This study compares two ways of removing hemorrhoids during surgery: one uses a standard electric tool, the other uses a special device (Caiman®) that seals blood vessels. It aims to see which method causes less pain after the operation.
Sabadell, BarcelonaAges 18–65 - NCT06559215RecruitingPhase 2
Pain management with Exparel after knee surgery in teens
This trial is testing a long-acting numbing medicine called Exparel to see how well it controls pain after a specific knee surgery (MPFL reconstruction) in teens and young adults. It may help reduce the need for strong painkillers after the operation.
Frisco, TexasAges 13–21 - NCT07401641Recruiting
Pain control study for oral cancer surgery
This study tests two different pain medicines (dezocine or nalbuphine) combined with sufentanil to see which helps better control pain after oral cancer surgery with free flap reconstruction. It also looks at side effects and how well the transplanted tissue survives.
Guangzhou, GuangdongAges 18–70 - NCT07783386Recruiting
Comparing nerve block volumes for breast surgery pain
This study compares different volumes of a nerve block (SPSIP) for pain relief after breast surgery. It aims to see if one volume provides better pain control with fewer side effects.
Nilufer, BursaAges 18–75 - NCT05444361Enrolling by invitation
Ultrasound freezing treatment for pain after mastectomy
This trial tests a “freezing” nerve procedure guided by ultrasound to help reduce pain after mastectomy. It aims to lessen postoperative pain by temporarily calming specific nerves involved in chest wall sensation.
Los Angeles, CaliforniaAges 18 years+ - NCT07221617RecruitingPhase 4
Methadone for pain after heart surgery
This trial tests whether a single dose of methadone given during heart surgery can improve pain control and recovery. It may be an option for people having planned (not emergency) heart surgery.
Rochester, MinnesotaAges 18 years+ - NCT07775053Enrolling by invitation
Pain relief study for breast cancer surgery
This study tests whether adding tramadol to a standard numbing medicine (ropivacaine) makes pain control better after breast cancer surgery. If you're having a mastectomy, this could help reduce pain and improve recovery.
Sargodha, Punjab ProvinceAges 20–70 - NCT06931743Recruiting
Electrical stimulation for pain after thyroid surgery
This trial tests if electrical stimulation can help reduce pain after thyroid surgery. It is for people who have at least moderate pain after their operation.
Shanghai, Changning DistrictAges 18 years+ - NCT07770932Recruiting
Pain relief after hip replacement surgery
This study compares two types of nerve blocks for pain relief after hip replacement surgery. It aims to find which method reduces pain and improves recovery.
Istanbul, BagcilarAges 18–80 - NCT07689162RecruitingPhase 2
Long-acting vs standard numbing for nose surgery pain
This study compares two types of numbing medicine used during open rhinoplasty (nose surgery) to see which one controls pain better after surgery. One is a long-acting version (liposomal bupivacaine) and the other is the standard numbing medicine (bupivacaine).
St Louis, MissouriAges 18 years+
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Common questions
- Are there clinical trials for postoperative pain?
- Yes. Clin2 currently lists 560 recruiting postoperative pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a postoperative pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a postoperative pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Postoperative Pain, Acute
- Postoperative Pain Management
- Chronic Postoperative Pain
- Total Knee Arthroplasty (Postoperative Pain)
- POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
- Postoperative Pain After Endodontic Treatment
- Postoperative Pain Following Knee Arthroplasty
- Postoperative Pain Management in Oral Surgery
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.