Clinical trials
Ovarian Insufficiency clinical trials
Below are recruiting ovarian insufficiency clinical trials, each written for real people, not researchers. We’re tracking 22 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06481969Recruiting
Fat cell therapy for premature ovarian failure
This trial uses your own fat cells (called stromal vascular fraction) to try to improve ovarian function and help you become pregnant if you have premature ovarian insufficiency. It may help restore your egg supply and menstrual cycles.
Beijing, Beijing MunicipalityAges 20–39 - NCT07115082RecruitingPhase 1/Phase 2
Stem cells from amniotic fluid for early menopause
This study tests whether stem cells from the fluid around a baby (amniotic membrane) can help women with premature ovarian insufficiency improve their chances of getting pregnant. It is designed for women under 40 who have not had a period for months and have high FSH levels.
ShanghaiAges 20–40 - NCT06866119Recruiting
Estrogen and heart health in women with early menopause
This study looks at how estrogen therapy affects heart health in women with primary ovarian insufficiency (early menopause). Participants will take a standard estrogen patch and progesterone pill, and researchers will monitor their heart function over time.
Boston, MassachusettsAges 30–40 - NCT06851754RecruitingPhase 3
Hormone therapy for teens with early menopause
This trial tests whether hormone replacement therapy (HRT) helps protect bone health in teenagers with premature ovarian insufficiency (POI). It compares HRT to a placebo and also includes healthy volunteers for comparison.
Bethesda, MarylandAges 11–19 - NCT06067529Recruiting
Study on the health effects of early menopause
This study follows women with premature ovarian insufficiency (POI) over time to understand how it affects their health. Researchers will collect samples and track health changes to learn more about the condition and its long-term effects.
Hangzhou, ZhejiangAges 10–65 - NCT07357701Recruiting
Genetic study for unexplained infertility in men and women
This study aims to find genetic causes of certain types of infertility in men and women. If you have been diagnosed with very low sperm count, no sperm, or early ovarian failure, researchers will look at your DNA to discover new genes that might be responsible.
Bethesda, MarylandAges 18–100 - NCT04167033Recruiting
Checking heart rhythm timing in women with premature ovarian insufficiency
This study measures how quickly the heart “recharges” between beats (often shown as QT timing). It compares women with premature ovarian insufficiency to healthy women to understand whether ovarian insufficiency is linked to heart rhythm differences.
BordeauxAges 18–40 - NCT07511660Enrolling by invitation
Ovarian cell injection for perimenopause symptom relief
This trial tests injecting special cells called Muse cells into the ovaries to help relieve perimenopause symptoms and possibly restore ovarian function. It may help women experiencing irregular periods, hot flashes, sleep problems, mood changes, or trouble thinking clearly.
Monterrey, Nuevo LeónAges 28–70 - NCT06096766Recruiting
Ovarian function and blood markers study
This study looks at how certain blood markers relate to ovarian function in women with normal ovaries, diminished ovarian reserve (DOR), or primary ovarian insufficiency (POI). It may help doctors better understand these conditions.
BeijingAges 18–45 - NCT05181748RecruitingPhase 2/Phase 3
Platelet-rich plasma into ovaries for low egg response
This trial tests whether injecting your own platelet-rich plasma (PRP) into the ovaries can improve egg production in people who don’t respond well to fertility stimulation. It may help some “poor responders” get more usable eggs for IVF.
Athens, AtticaAges 35–47 - NCT07509840RecruitingPhase 3
Immune therapy to restore ovary function and fertility
This trial tests whether an immune-modulating drug can restart ovulation and improve fertility in women whose ovaries stopped working due to autoimmune disease. It is for women ages 18–38 with autoimmune premature ovarian insufficiency and certain antibodies.
StockholmAges 18–38 - NCT04948658Recruiting
Freezing ovarian tissue to protect future fertility
This study looks at storing ovarian (ovary) tissue by freezing it for people at higher risk of losing fertility. It may help preserve options for having biological children later, especially for certain genetic conditions, cancer-related risks, or planned gonad removal.
Bethesda, MarylandAges 2–35 - NCT01870752Recruiting
Transplanting frozen ovarian tissue to help you try for pregnancy
This trial studies whether thawed, previously frozen ovarian tissue can be transplanted to help people with ovarian insufficiency become pregnant. It may help if you already have cryopreserved ovarian tissue stored and your care team feels you’re a good candidate for the procedure.
Philadelphia, PennsylvaniaAges 18–45 - NCT06645379Recruiting
Platelet-rich plasma for fertility treatments
This trial tests whether injecting platelet-rich plasma (a concentrate from your own blood) into the uterus or ovaries can help women with certain fertility issues, such as damaged uterine lining, scarring, or low egg reserve. It aims to improve pregnancy chances in these challenging cases.
Yiwu, ZhejiangAges 18–50 - NCT05858307Recruiting
Testing AMH blood levels for PCOS and POI patients
This study looks at how a blood test called AMH (anti-Müllerian hormone) is used in people being seen for PCOS or POI (early ovarian failure). The goal is to understand whether AMH measurements are useful for care in clinics and fertility treatment settings.
Hong KongAges 10–44 - NCT05567198Recruiting
Testing hormone shots to protect ovaries during lupus chemotherapy
This study looks at whether a monthly/3-month hormone medicine (a “GnRH shot”) can help protect ovaries in people with lupus who are treated with cyclophosphamide. It also compares this to lupus patients who do not receive the ovarian-protecting shot, using questionnaires to track outcomes.
Bethesda, MarylandAges 18–120 - NCT03989154Recruiting
Study for ovarian insufficiency in people under 40
This trial looks at treatment options for people under age 40 who have stopped having periods for at least four months and have lab results that suggest ovarian function is low. It may help improve symptoms or hormone balance for those who fit the hormone pattern.
Zhengzhou, HenanAges 18–40 - NCT05327283Recruiting
Genetic testing for early menopause in younger people
This study looks at DNA changes to understand the cause of premature ovarian insufficiency (early menopause). It may help clarify what’s happening in your body and guide future care.
GenovaAges 15–38 - NCT06167135Recruiting
PCOS, Insulin Resistance, and Fertility Study
This study looks at how polycystic ovary syndrome (PCOS) and insulin resistance (a condition where your body doesn't use insulin well) are linked to energy problems in cells (mitochondrial dysfunction). It aims to understand how these conditions affect fertility in women.
BudapestAges 20–45 - NCT07775391RecruitingPhase 1/Phase 2
Stem cell infusion for early menopause
This trial tests whether a single infusion of stem cells made from human umbilical cord tissue can help women with premature ovarian insufficiency (early menopause) by improving ovarian function and reducing menopause symptoms. Participants will continue their usual hormone replacement therapy during the study.
Beijing, Beijing MunicipalityAges 18–40 - NCT06357442Recruiting
Comparing progesterone methods for young people on estrogen therapy
This study compares two ways to give progesterone to young people on estrogen replacement therapy to see how they affect the lining of the uterus. It will help find which approach may be safer and more effective for your health.
Aurora, ColoradoAges 12–25 - NCT06834594RecruitingPhase 4
Bleeding patterns in teens with Turner syndrome on progesterone
This study looks at how different ways of taking progesterone (a hormone given along with estrogen) affect bleeding patterns in teens with Turner syndrome. The goal is to find the best hormone schedule to cause regular, predictable periods.
Kansas City, MissouriAges 12–20
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Common questions
- Are there clinical trials for ovarian insufficiency?
- Yes. Clin2 currently lists 22 recruiting ovarian insufficiency studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a ovarian insufficiency trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a ovarian insufficiency trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.