Clinical trials
Preoperative clinical trials
Below are recruiting preoperative clinical trials, each written for real people, not researchers. We’re tracking 382 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05428358Recruiting
MRI helps choose which pancreatic cancer patients can have surgery
This trial studies whether adding an MRI scan improves the selection of people with pancreatic cancer who may benefit from surgery. It focuses on patients without liver spread and with tumors that are borderline or likely removable.
AalborgAges 18–99 - NCT05447273Recruiting
MRI to plan less invasive surgery for penile cancer
This trial studies how functional MRI scans (a special MRI that shows how tissues work) can help doctors plan surgery for newly diagnosed penile squamous cell cancer. It may help more people get organ-sparing surgery, which aims to remove the cancer while preserving as much function as possible.
OsloAges Any age - NCT05447442Recruiting
Use a pre-surgery plan to treat anemia before an operation
This trial looks at whether following a hospital guideline to treat anemia before surgery helps patients have better pre-op care. You may be eligible if you have anemia found during a pre-anesthesia clinic visit.
Bangkok, BangkokAges Any age - NCT05520593Recruiting
Drinking plan before surgery to support same-day joint replacement
This trial tests whether a specific pre-surgery oral drinking (hydration) plan can help people feel and recover better after outpatient (same-day) hip or knee replacement surgery. It may help support safe same-day discharge for the right patients.
New York, New YorkAges 18–75 - NCT05545007Recruiting
Pre-op vs post-op focused radiation for large brain metastases
This study compares giving focused, high-dose radiation before surgery versus after surgery for people with large brain metastases. The goal is to see which timing works best to control the tumors and help neurological outcomes.
Brescia, BresciaAges 18 years+ - NCT05609084Recruiting
Speech therapy before surgery for drug-resistant temporal epilepsy
This study tests an intensive pre-surgery speech rehabilitation program for people whose seizures come from the language-related area in the temporal part of the brain. The goal is to improve speech outcomes before planned epilepsy surgery.
BordeauxAges 16 years+ - NCT05673304Recruiting
Boost treatment before surgery for luminal B breast cancer
This trial tests a “boost” treatment given before surgery along with standard chemotherapy for luminal B–type breast cancer. It may help improve outcomes by strengthening treatment before the tumor is removed.
BolognaAges 18 years+ - NCT05702944RecruitingPhase 4
Skipping pre-surgery blood pressure medicine for certain adrenal tumors
This trial studies whether it is safe to skip a specific pre-surgery blood pressure medicine (alpha-blocker) for people with normal blood pressure who have a pheochromocytoma or paraganglioma in one adrenal gland. It aims to see if fewer pre-op meds can still prevent risky blood pressure surges during surgery.
SeoulAges 19–70 - NCT05726370RecruitingPhase 2
Pembrolizumab plus chemo before surgery for recurrent head and neck cancer
This Phase 2 trial tests whether giving pembrolizumab (an immune therapy) plus chemotherapy before curative surgery can improve outcomes for people with resectable, recurrent head and neck squamous cell cancer. It also studies how these treatments affect the tumor and immune response using required tissue and blood samples.
Boston, MassachusettsAges 18 years+ - NCT05726786RecruitingPhase 3
Immunonutrition before bladder removal surgery
This study tests whether a special nutrition drink given before open bladder surgery can reduce complications and improve the body’s immune response after surgery. It’s for adults having bladder removal and is compared against standard care.
Lausanne, Canton of VaudAges 18 years+ - NCT05743673Recruiting
SHAPE test to assess pre-surgery heart and lung risk
This trial studies a quick physical test (called the SHAPE test) given before surgery to help predict your risk of complications. It may help doctors choose safer care and monitoring based on your results.
New Haven, ConnecticutAges 60 years+ - NCT05748145RecruitingPhase 2
Metronidazole before colon cancer surgery to reduce recurrence risk
This Phase 2 study tests whether taking metronidazole, an antibiotic, before surgery for colorectal cancer can improve outcomes. Participants take it before their planned operation, and doctors study the cancer tissue and related markers to see if it helps.
Bellinzona, Canton TicinoAges 18 years+ - NCT05752136RecruitingPhase 3
Pre-surgery radiation plus immunotherapy and chemo for rectal cancer
This trial tests whether a short course of radiation before surgery, combined with the immunotherapy drug envafolimab and the chemo regimen CAPEOX, works better for shrinking locally advanced rectal cancer. It is aimed at people whose tumor is not “MMR-deficient” (it is pMMR/MSS), and it asks participants to be able to return for repeated checkups and treatments.
Hangzhou, ZhejiangAges 18 years+ - NCT05760339Recruiting
Intermittent fasting vs carbohydrate drinks before elective surgery
This study compares two ways of eating before planned (elective) orthopedic surgery: intermittent fasting versus carbohydrate drinks. It aims to see which approach is safer and works better around the time of surgery.
Amsterdam, North HollandAges 18 years+ - NCT05761054Recruiting
Pre-surgery radiation to shrink soft-tissue sarcoma
This trial studies giving radiation before surgery to help control a soft-tissue sarcoma while keeping surgery as less extensive as possible. It may help shrink the tumor and improve what the surgeon can remove.
Florence, FiAges 18 years+ - NCT05788770Recruiting
CT scan and computer planning before TAVR valve replacement
This study uses a CT scan plus a personalized computer model to plan a less invasive valve replacement (TAVR). It may help doctors better prepare for the procedure using simulation before your valve is placed.
ViennaAges 18 years+ - NCT05808933Recruiting
MRI test before surgery for early cervical cancer spread risk
This trial studies whether a special MRI scan can better predict whether early cervical cancer has spread into tiny lymph and blood vessels (lymphovascular space invasion) before surgery. If it works, it may help doctors plan the best treatment after surgery.
RomaAges 18 years+ - NCT05810571Recruiting
Pain-control injections compared after open kidney surgery
This study compares two types of pain-control injections placed near the back to see which works better after open kidney (nephrectomy) surgery. If you’re having elective open nephrectomy, it may help doctors choose the safest and most effective way to reduce postoperative pain.
İzmitAges 18–85 - NCT05833386Recruiting
Silodosin before surgery to help pass an access sheath
This trial looks at whether taking silodosin before flexible ureteroscopy makes it easier to place a special tube (ureteral access sheath) used during kidney stone surgery. If it works, it may make the procedure more feasible and smoother for people having the planned surgery.
CairoAges 18 years+ - NCT05848310Recruiting
Blood test before surgery to predict biliary atresia outcome
This study looks at a specific pre-surgery blood marker called FGF19 (and related liver blood tests) in children with biliary atresia. The goal is to see whether the blood results before surgery can help predict how well children recover after surgery.
Shanghai, Shanghai MunicipalityAges Any age - NCT05884723Recruiting
Ketogenic diet before liver surgery for fatty liver
This trial tests whether a ketogenic (very low-carb) diet before liver surgery can reduce fat in the liver. It is aimed at people with colorectal liver metastases who already have fatty liver seen on scans or biopsy.
London, OntarioAges 18 years+ - NCT05893342Recruiting
Checking frailty during surgery in older adults
This study looks at “frailty,” or how well the body may handle stress, around the time of surgery in people age 65 and older. It may help doctors better understand who is at higher risk and how to plan care around surgery.
Las Palmas de Gran Canaria, Las PalmasAges 65 years+ - NCT05924178Recruiting
Pre-surgery rehab to improve healing after knee ligament injury
This study looks at whether doing physical therapy before surgery can improve tendon healing, bone density, and joint cushioning after ACL surgery or patellar dislocation surgery. It may help you recover better and faster by optimizing your knee before the operation.
BeijingAges 18–45 - NCT06001489Recruiting
Virtual reality for anxiety before heart surgery
This trial tests whether watching a 360-degree virtual reality video can help reduce anxiety before heart surgery. If you are waiting for elective heart surgery and are at least 18 years old, you may be able to participate.
Amsterdam, North HollandAges 18 years+
Hear when a new Preoperative trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for preoperative?
- Yes. Clin2 currently lists 382 recruiting preoperative studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a preoperative trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a preoperative trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.