Clinical trials
Primary Liver Cancer clinical trials
Below are recruiting primary liver cancer clinical trials, each written for real people, not researchers. We’re tracking 230 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06440005RecruitingPhase 1
Testing AGX101 for advanced solid tumors
This study tests a new drug called AGX101 for people with advanced solid tumors that have not responded to other treatments. The goal is to see if it is safe and if it can shrink tumors or slow their growth.
Los Angeles, CaliforniaAges 18 years+ - NCT02172651RecruitingEarly Phase 1
Vitamin D during early colon cancer or liver surgery
This trial studies whether taking higher-dose vitamin D3 around the time of colon cancer (or colon cancer with resectable liver metastases) surgery improves outcomes. It focuses on safety and possible effects on cancer-related health after surgery.
Boston, MassachusettsAges 18 years+ - NCT05576974RecruitingPhase 2
Test a dye used during surgery to find head and neck cancer
This trial tests whether a single dose of an imaging dye (given during surgery) can help doctors find the unknown origin of head and neck cancer and check safety. It may help guide surgery and biopsies when the primary cancer location hasn’t been identified.
Dallas, TexasAges 18–99 - NCT04079049RecruitingPhase 3
Local treatment for breast cancer spread to the liver
This study tests a local (targeted) approach for breast cancer that has spread to the liver. It looks at whether treating liver metastases with planned liver surgery, along with standard cancer treatment before and after, can improve outcomes.
UmeåAges 18 years+ - NCT04668872Recruiting
Biopsy after liver radiation to see tumor cell changes
This trial gives radiation to liver tumors and then takes a small tissue sample (biopsy) to look for changes in the cancer cells after treatment. The goal is to learn what the radiation is doing inside the tumor, which may help improve future treatments.
New York, New YorkAges 18 years+ - NCT05855811RecruitingPhase 2
Preventing a Second Cancer After Your First Cancer
This Phase 2 trial tests dostarlimab, an immune-based medicine, to help lower the chance of getting a second (new) cancer after treatment for a first solid tumor. It’s for people with higher risk features, and it aims to see whether the drug can prevent or delay second cancers.
CaenAges 18 years+ - NCT07318051Recruiting
Sample collection for cancer research study
This study collects blood and tumor tissue samples from patients with certain untreated cancers to help researchers develop and improve tests. You may be eligible if you have one of the listed cancer types and have not yet started treatment.
Austin, TexasAges 18 years+ - NCT05377996RecruitingPhase 1/Phase 2
Study drug for advanced solid tumors with tumor tissue testing
This early-stage study tests emiltatug leda-dotin (Emi-Le) in people with advanced or recurring solid cancers. It aims to see how the drug works and how safely it can be given, using tumor tissue testing to help understand who may benefit.
Phoenix, ArizonaAges 18 years+ - NCT06856499RecruitingPhase 1
Cirtuvivint and Olaparib for BRCA-related ovarian cancer
This trial tests a combination of two targeted drugs, cirtuvivint and olaparib, for a specific type of ovarian cancer that no longer responds to platinum chemotherapy. It may be an option if you have a BRCA mutation or HRD-positive tumor and have already tried a PARP inhibitor.
Aurora, ColoradoAges 18 years+ - NCT05057052RecruitingPhase 2
Freezing liver tumors with immunotherapy and a pill drug
This Phase 2 trial tests whether freezing (cryoablation) plus sintilimab (an immune system medicine) and regorafenib (a pill) can shrink colorectal cancer that has spread to the liver. It is for people whose cancer has come back or progressed after at least two prior chemotherapy treatments.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05240950RecruitingPhase 1
CAR-T cell therapy for colorectal cancer in the liver
This Phase 1 study tests an anti-CEA CAR-T cell treatment for people whose colorectal cancer spread to the liver but has been surgically removed with no visible remaining tumor. It aims to see if the treatment can better prevent the cancer from coming back, especially when early warning tests suggest leftover cancer cells.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05861505RecruitingPhase 3
Treatment for new liver spread from colon cancer recurrence
This Phase 3 trial studies a treatment approach for people whose colorectal cancer has come back in the liver within 12 months and can be treated with local procedures. It aims to see whether the study treatment can improve outcomes compared with standard care for people with a limited number of liver tumors.
AmsterdamAges 18 years+ - NCT06630624RecruitingPhase 1/Phase 2
IP-001 with ablation for colorectal liver metastases
This trial tests whether adding the drug IP-001 to tumor ablation (microwave or irreversible electroporation) helps control colorectal cancer that has spread to the liver. The goal is to find the best dose and see how the immune system responds.
Amsterdam, North HollandAges 18 years+ - NCT06848465RecruitingPhase 1
Radiation plus chemo-immunotherapy for colon cancer with liver spread
This trial tests a combination of low-dose radiation, chemotherapy, and immunotherapy for people with colorectal cancer that has spread only to the liver. The goal is to see if this approach can shrink tumors and improve outcomes.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT07537205Enrolling by invitation
Nurse-led preparation program for liver cancer surgery
This study tests whether a personalized preparation program led by nurses before liver cancer surgery helps patients recover better and have fewer complications. The program is designed specifically for people scheduled to have part of their liver removed.
Shanghai, XuhuiAges 18–84 - NCT05236686Recruiting
Surgery to remove upper abdomen lymph nodes for ovarian cancer
This trial studies whether removing lymph nodes in the upper abdomen (hepatoceliac lymph nodes) improves outcomes for people with stage III or IV ovarian, fallopian tube, or primary peritoneal cancer that has spread to those lymph nodes. It also looks at how this surgery works for people with certain types of relapse, often alongside chemotherapy.
ShanghaiAges 18–75 - NCT06690528RecruitingPhase 2
Surgery vs. palliative care for pancreatic cancer with limited liver spread
This trial compares surgery to remove the primary tumor and up to 3 liver spots against standard palliative care for people with pancreatic cancer that has spread only to the liver (up to 3 spots). It is for those whose cancer has not grown after initial chemotherapy and who are healthy enough for surgery.
Padova, ItalyAges 18–75 - NCT05926336RecruitingPhase 4
Different anesthesia drugs during cancer surgery
This trial compares two types of anesthesia medicines to see how they may affect outcomes after surgery for certain primary cancers. You may be considered if you’re having planned (elective) surgery under general anesthesia and meet the safety and health criteria.
Kaohsiung CityAges 20–80 - NCT06541652Recruiting
Study of rare liver cancers in France
This study looks at people with rare types of liver cancer to learn more about the disease. If you have one of these rare liver cancers, your information could help doctors understand these cancers better.
AmiensAges 18 years+ - NCT06899854Recruiting
Collecting blood and tissue from patients with liver cancer
This study collects blood and tumor tissue samples from people with primary liver cancer who are starting their first treatment (systemic therapy or surgery). The samples help researchers learn more about these cancers and how to improve future treatments.
Pavia, PaviaAges 18–90 - NCT06914648Recruiting
Liver preparation before surgery study for certain liver cancers
This study tests a procedure called portal vein embolization (PVE) to help grow the healthy part of the liver before surgery. It may be an option for people with certain liver cancers who need more healthy liver tissue before their operation.
New Haven, ConnecticutAges 18 years+ - NCT06990659Recruiting
Outpatient vs. Inpatient Liver Cancer Treatment Study
This study compares having your liver cancer treatment (TACE or TARE) as an outpatient versus staying in the hospital overnight. It's for people with primary liver cancer whose liver and kidney function are good enough and who can safely go home the same day with support.
AmiensAges 18 years+ - NCT07312292RecruitingPhase 2
Radioembolization with angiotensin II to boost tumor radiation dose
This trial tests whether adding a drug called angiotensin II (which tightens blood vessels in healthy tissue) during radioembolization can deliver more radiation directly to liver tumors. It is for people who have liver tumors (either primary or that have spread to the liver) and are scheduled for radioembolization.
Utrecht, UtrechtAges 18 years+ - NCT07392567Recruiting
AI predicts liver spread in colorectal cancer
This study tests whether an artificial intelligence (AI) model can predict if colon or rectal cancer will spread to the liver. You will have a CT scan before surgery, and the AI will analyze the scan to see if it can forecast future liver metastasis.
Wuhan, HubeiAges 18–75
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Common questions
- Are there clinical trials for primary liver cancer?
- Yes. Clin2 currently lists 230 recruiting primary liver cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a primary liver cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a primary liver cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.