Clinical trials
Radiation Therapy clinical trials
Below are recruiting radiation therapy clinical trials, each written for real people, not researchers. We’re tracking 686 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04165772RecruitingPhase 2
Dostarlimab for locally advanced mismatch-repair deficient solid tumors
This Phase 2 trial studies dostarlimab (an immune therapy that targets PD-1) given before surgery or other initial treatment. It aims to shrink certain locally advanced cancers that have mismatch repair deficiency, potentially making treatment easier and improving outcomes.
Hartford, ConnecticutAges 18 years+ - NCT04178174RecruitingPhase 3
Boost radiation for HPV throat cancer with shorter treatment
This trial studies whether adding a precise “extra boost” to radiation can work as well as (or better than) standard radiation for HPV-related oropharynx cancer, while keeping the overall treatment shorter. It may help improve tumor control while aiming for manageable side effects.
London, OntarioAges 18 years+ - NCT04181684Recruiting
Laser surgery plus targeted radiation for recurrent brain gliomas
This trial studies whether a special laser procedure (LITT) followed by focused, reduced-dose radiation can control glioma tumors that have come back. It may help people with recurrent brain tumors avoid or delay more extensive treatment.
Baltimore, MarylandAges 22 years+ - NCT04188535Recruiting
MRI scans during radiation treatment
This study does repeated MRI (detailed brain/body imaging) while you receive radiation therapy. It aims to see how these serial scans relate to treatment and outcomes, which could help improve care planning for different cancers.
Boston, MassachusettsAges 18 years+ - NCT04249154RecruitingPhase 2
After prostate surgery, test radiation plus hormone shots
This trial studies whether giving a shorter-course radiation plan after prostate surgery, along with hormone shots (LHRH), can improve outcomes for people with higher-risk prostate cancer. You may be eligible if your PSA (a blood marker) is either still low but high-risk by pathology, or it has started to rise again after surgery.
Montreal, QuebecAges 18 years+ - NCT04266223Recruiting
Head and neck mask monitoring during radiation to improve setup
This trial tests a surface-monitoring technology that checks a head-and-neck radiation “positioning mask” during treatment. It may help the radiation team make sure the mask and patient are aligned correctly for safer, more accurate therapy.
Blacktown, New South WalesAges 18 years+ - NCT04322318RecruitingPhase 2
Study of combination chemotherapy for Wilms tumor in children
This Phase 2 trial tests combination chemotherapy for children with certain types of Wilms tumor—either newly diagnosed diffuse anaplastic Wilms tumor or favorable Wilms tumor that has come back. The goal is to see how well the treatment controls the tumor and is tolerable for children.
Birmingham, AlabamaAges Up to 30 years - NCT04368702Recruiting
MRI-guided radiation for people needing radiation for cancer
This study tests whether radiation given with help from MRI (a type of scan) can better treat cancers that need radiation. You may be eligible if your cancer is confirmed and you can safely have MRI scans.
Boston, MassachusettsAges 18 years+ - NCT04375904RecruitingPhase 2
Stereotactic radiation for central lung tumors
This trial tests a precise, high-dose radiation treatment aimed at central lung tumors. It may help people who cannot have lung surgery and whose tumors can be safely targeted near sensitive organs.
DublinAges 18 years+ - NCT04380831RecruitingEarly Phase 1
Whole-body radiation plus chemo before stem cell transplant
This early-stage trial studies whether giving whole-body radiation and a chemotherapy medicine before an autologous stem cell transplant can improve severe systemic sclerosis. It aims to reset the immune system, but it requires careful safety checks and close follow-up.
Duarte, CaliforniaAges 18–65 - NCT04430452RecruitingPhase 2
Durvalumab with or without tremelimumab after liver radiation
This study tests whether the immunotherapy drugs durvalumab (with or without tremelimumab) can help control hepatocellular carcinoma (liver cancer) after you receive palliative, targeted radiation. It especially focuses on people whose cancer continued to grow after, or without, certain prior immune therapies.
San Francisco, CaliforniaAges 18 years+ - NCT04546399RecruitingPhase 2
Blinatumomab with or without nivolumab for first relapse ALL
This study compares blinatumomab alone versus blinatumomab plus nivolumab in young people whose B-cell ALL has returned for the first time. It aims to see whether adding nivolumab improves control of the leukemia after relapse.
Birmingham, AlabamaAges 1–30 - NCT04563507RecruitingPhase 2
Immunotherapy plus hormone therapy for metastatic ER-positive breast cancer
This Phase 2 study tests a combination of immune-based treatments along with hormone (endocrine) therapy to slow or shrink advanced, hormone-receptor positive, HER2-negative breast cancer. You may be a candidate if your cancer has progressed after standard hormone-blocking medicines and you can start treatment with CDK4/6 medicine plus an aromatase inhibitor.
New York, New YorkAges 18–90 - NCT04603209Recruiting
Check-in registry for radiation during breast-conserving surgery
This registry study tracks people with early-stage, single-area breast cancer to understand outcomes when radiation is given during breast-conserving surgery. It may help doctors improve treatment planning for patients like you.
Santa Monica, CaliforniaAges 18 years+ - NCT04684368RecruitingPhase 2
New treatment study for children and young adults with NGGCT brain tumors
This Phase 2 study tests a new treatment approach for certain brain tumors called NGGCT in children and young adults. It may help improve outcomes by targeting tumors in specific brain locations and using tumor marker tests to guide care.
Birmingham, AlabamaAges 3–29 - NCT04699773Recruiting
Laser treatment then focused radiation for new brain gliomas
This trial studies a two-step treatment for newly diagnosed high-grade glioma: first laser treatment (LITT) to target the tumor, followed by a shorter, more focused course of radiation. It may help shrink or control the tumor while limiting treatment time.
Baltimore, MarylandAges 18 years+ - NCT04732065RecruitingPhase 1
ONC206 for certain brain tumors in children and young adults
This Phase 1 study tests ONC206, a new targeted medicine, for diffuse midline gliomas (DMG) with a specific gene change (H3K27 altered) and for some other recurrent brain/spinal cord cancers. It is designed to find the right dose and see whether it can control or shrink tumors after initial treatment or when the cancer returns.
San Francisco, CaliforniaAges 2–21 - NCT04745390Recruiting
Testing a tailored radiation dose plan for liver tumors
This study compares a standard radiation dose plan versus a plan that adjusts the dose based on how the tumor responds to radiation-related measurements. It aims to improve how well stereotactic body radiation therapy (SBRT) treats liver cancer while keeping side effects manageable.
London, OntarioAges 18 years+ - NCT04805528Recruiting
Electrical stimulation to reduce dry mouth after head-neck radiation
This trial tests a non-invasive, acupuncture-like electrical stimulation treatment (ALTENS) to help reduce dry mouth after radiation for head and neck cancers. You may qualify if you have bothersome dry mouth and had significant head-neck radiation, with no signs of active cancer and if you can come for treatments over 12 weeks.
Rochester, New YorkAges 18 years+ - NCT04854213Recruiting
Study checks radiation effects in colon cancer lung-limited spread
This trial studies how targeted radiation (SBRT) affects cancer biology and immune cells in people with colon cancer that has spread only to a small number of lung nodules. Your tumor tissue will be analyzed to see what changes after treatment.
Naples, NAPOLIAges 18–80 - NCT04959474Recruiting
Pre-surgery radiation study with or without calorie restriction
This trial looks at whether a planned calorie-reduction diet before surgery can change how early breast cancer responds to a short course of radiation. It may help people understand if diet could improve outcomes alongside standard pre-surgery treatment.
Philadelphia, PennsylvaniaAges 40 years+ - NCT05011045Recruiting
Brain radiation study tracking thinking and memory changes
This study looks at how whole-brain radiation affects thinking, memory, and other brain function in people with blood cancers that involve the brain. It may help doctors understand what to expect and which supportive treatments or monitoring could be useful.
Houston, TexasAges 18 years+ - NCT05013892RecruitingPhase 2
Whole-brain radiation with a targeted drug plan for brain mets
This Phase 2 study tests a treatment plan that combines whole-brain radiation therapy with an additional approach to help people with brain metastases. It aims to improve outcomes while also tracking brain function and memory over time.
Boston, MassachusettsAges 18 years+ - NCT05045950RecruitingPhase 2
Whole brain radiation that aims to protect thinking skills
This Phase 2 trial tests a modified form of whole brain radiation to see if it can better protect thinking and memory in adults with brain metastases. You may join even if you’ve had other cancer treatments before, as long as your situation fits the study rules.
Milwaukee, WisconsinAges 18 years+
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Common questions
- Are there clinical trials for radiation therapy?
- Yes. Clin2 currently lists 686 recruiting radiation therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a radiation therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a radiation therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.