Clinical trials
Recurrent or Metastatic Solid Tumors clinical trials
Below are recruiting recurrent or metastatic solid tumors clinical trials, each written for real people, not researchers. We’re tracking 3,361 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04819243RecruitingPhase 2
Test a BRCA-targeted drug plan for advanced ER-positive breast cancer
This Phase 2 study tests how well a treatment plan using palbociclib followed by talazoparib (and possibly atezolizumab) works in certain people with advanced ER-positive breast cancer. It may help by targeting cancer biology linked to BRCA/HRD changes and by strengthening how the cancer is controlled.
Seoul, Gannam-guAges 19 years+ - NCT05382728RecruitingPhase 3
Test drug for EGFR-mutant lung cancer without prior treatment
This Phase 3 trial studies TY-9591 in people with locally advanced or metastatic non-small cell lung cancer (NSCLC) that has specific EGFR gene changes. It’s for those who haven’t had earlier medicines for advanced lung cancer, and it aims to see if the drug works better or safer than the comparison treatment.
Changsha, HunanAges 18–80 - NCT06767306RecruitingPhase 2
SBRT radiation plus immunotherapy for limited spread melanoma
This trial tests if combining targeted radiation (SBRT) with standard immunotherapy works better for melanoma that has spread to a few spots in the body (but not the brain). It is for people who have not yet had treatment for their current spread.
Westmead, New South WalesAges 18 years+ - NCT04725422Recruiting
Registry for children with nonbacterial bone inflammation
This study collects medical information (and imaging results) from children and teens with nonbacterial bone inflammation. It may help doctors better understand how this condition looks on scans and how it’s diagnosed, especially to rule out infection or cancer.
Seattle, WashingtonAges Up to 21 years - NCT05116514Recruiting
Case manager support to prevent repeat psychosis in young people
This study tests whether adding a case manager can help reduce how often psychotic symptoms come back within 3 years after a first psychotic episode. It may help by keeping care organized and support consistent during recovery.
Toulouse, Choisir Une RégionAges 16–30 - NCT05019716RecruitingPhase 1/Phase 2
Adding ZEN003694 to chemo for NUT cancer
This early-phase study tests whether adding ZEN003694 to standard chemotherapy (cisplatin/etoposide or carboplatin/paclitaxel) is safe and can help control NUT carcinoma. It enrolls people ages 12–17 and adults, including some patients whose cancer has spread or can’t be safely removed.
Los Angeles, CaliforniaAges 12 years+ - NCT04297085Recruiting
Study of why blood clots in veins come back
This study follows people who have had a vein blood clot (or related venous clot) to understand what factors may make the clot happen again. It may help clinicians find better ways to prevent repeat clots.
BrestAges Any age - NCT04070040RecruitingPhase 2
Camrelizumab for returning brain lymphoma after prior treatment
This trial studies camrelizumab (an immune medicine) for primary CNS lymphoma that has come back after standard treatment. It aims to shrink the lymphoma seen on MRI and help control the disease with a new immune-based approach.
BeijingAges 18 years+ - NCT04440436RecruitingPhase 1/Phase 2
IM19 study for relapsed or refractory non-Hodgkin lymphoma
This trial tests whether IM19 can safely and effectively treat non-Hodgkin lymphoma that has come back or did not respond to prior treatment. It is for adults with certain lymphoma markers and good overall functioning.
Beijing, Beijing MunicipalityAges 18 years+ - NCT03025932Enrolling by invitation
Study recurrence after laparoscopic hiatal hernia repair with mesh
This study looks at how often a large hiatal hernia comes back after a specific surgery: laparoscopic repair using mesh plus an anterior fundoplication. It may help surgeons better choose the technique that lowers the chance of recurrence.
Ages 18 years+ - NCT03583710RecruitingPhase 3
Mitotane after adrenal tumor surgery, with or without chemo
This study looks at whether giving mitotane after surgery (and possibly adding cisplatin/etoposide chemotherapy) helps prevent adrenal cancer from coming back. It is for people with stage I–III adrenal cortical cancer who have a high risk of relapse after their tumor was removed.
Ann Arbor, MichiganAges 18 years+ - NCT05530057RecruitingPhase 2
Eribulin plus or minus trastuzumab for HER2-positive breast cancer
This trial tests whether adding trastuzumab to eribulin improves outcomes for people with HER2-positive breast cancer that has come back or spread. It’s meant for patients whose cancer has progressed after prior HER2 and chemotherapy treatments.
SeoulAges 18 years+ - NCT04086290RecruitingPhase 1/Phase 2
Surgery plus targeted radiation for prostate cancer spread
This study looks at whether combining prostate surgery with a highly focused radiation treatment (SBRT) can control prostate cancer that has spread to a limited number of bones. It may help patients by treating the main tumor and the specific metastatic spots in a controlled way.
HerlevAges 18 years+ - NCT03994978Recruiting
Compare bowel function after sigmoid surgery vs watchful care
This study looks at whether having elective sigmoid colon surgery helps bowel function and quality of life compared with conservative (non-surgery) care in people with recurrent, uncomplicated diverticulitis. It may help clarify which approach leads to fewer ongoing bowel problems and better daily comfort.
BaselAges 18 years+ - NCT04220905Recruiting
Watching outcomes after removing large colon and duodenal polyps
This observational study follows people who have large polyps in the colon or duodenum that are removed during endoscopy. It aims to understand how safe and effective this approach is, and what outcomes patients have afterward.
White River Junction, VermontAges 18 years+ - NCT03073278Recruiting
Targeted re-radiation for prostate cancer recurrence in one area
This study tests a focused radiation treatment (SBRT) to a small, clearly identified spot in the prostate for men whose prostate cancer has come back after prior external beam radiation. It may help control cancer while limiting radiation to the rest of the prostate and nearby organs.
St Leonards, New South WalesAges 18 years+ - NCT05203913RecruitingPhase 2
Bladder cancer trial adds chemo, immunotherapy, and radiation after surgery
This Phase 2 study tests whether adding chemotherapy and immunotherapy along with targeted pelvic radiation after bladder tumor surgery can reduce bladder cancer returning or spreading. It focuses on people with non-metastatic, muscle-invasive urothelial bladder cancer.
RomaAges 18 years+ - NCT06199180Recruiting
Comparing two ablation methods for repeat atrial fibrillation treatment
This trial tests a newer type of energy (pulsed field ablation) against the standard heat-based method (radiofrequency) for people who have already had one ablation and now have atrial fibrillation again. The goal is to see which works better for keeping your heart in a normal rhythm.
GroningenAges 18–80 - NCT06812039RecruitingPhase 2
Perioperative treatment for high-risk liver cancer using HAIC, donafenib, and sintilimab
This trial tests a combination of treatments—chemotherapy delivered through the liver artery (HAIC), a targeted drug (donafenib), and an immunotherapy (sintilimab)—given before and after surgery for liver cancer that has a high chance of coming back. The goal is to see if this approach can lower the risk of recurrence.
Fuzhou, FujianAges 18–75 - NCT02792270Recruiting
Calorie reduction during pre-surgery radiation for leg sarcoma
This trial studies whether eating fewer calories before surgery, along with standard pre-surgery radiation, can improve outcomes for adults with leg soft-tissue sarcoma. If you qualify, you’d follow a calorie-reduction plan and then proceed to surgical removal of the tumor.
Boston, MassachusettsAges 18 years+ - NCT01033838RecruitingPhase 2
Two minimally invasive surgery options for recurrent diverticular problems
This trial compares two types of minimally invasive surgery for people with recurrent diverticular disease who need surgery for a benign (non-cancerous) polyp and have an early, limited tumor in the sigmoid colon/rectosigmoid area. It may help find which approach is safer or better for recovery.
LeuvenAges 18–90 - NCT03692429RecruitingPhase 1
Testing new immune cells plus chemo for advanced colon cancer
This Phase 1 study tests CYAD-101, an immune-cell treatment made from donor T-cells, given with standard chemotherapy. It is for people with colon or rectal cancer that has spread and has not responded to prior treatments.
Tampa, FloridaAges 18 years+ - NCT03675672RecruitingPhase 4
Preventing repeat bleeding from stomach or upper gut ulcers
This trial studies medicines to help stop bleeding from coming back after you’ve had an “idiopathic” stomach/upper gut ulcer bleed. It may help by reducing ulcer re-bleeding risk in people who don’t have common causes like H. pylori or common ulcer-triggering drugs.
Hong KongAges 18 years+ - NCT06205862RecruitingPhase 2
Fecal transplant for preventing colon polyp return
This study tests whether taking capsules of healthy bacteria (fecal microbiota transplant) can help prevent colon polyps from coming back after they have been removed. It might be an option for people who have had an adenoma polyp removed and want to reduce the chance of recurrence.
Guangzhou, GuangdongAges 18–75
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Common questions
- Are there clinical trials for recurrent or metastatic solid tumors?
- Yes. Clin2 currently lists 3,361 recruiting recurrent or metastatic solid tumors studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a recurrent or metastatic solid tumors trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a recurrent or metastatic solid tumors trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.