Clinical trials
Spine Degeneration clinical trials
Below are recruiting spine degeneration clinical trials, each written for real people, not researchers. We’re tracking 31 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05746143RecruitingPhase 4
Zolpidem during recovery after lower-back fusion surgery
This trial studies whether taking zolpidem around the time of recovery from lower-back (lumbar) fusion surgery affects outcomes. It may help doctors understand how sleep medicine can (or can’t) support recovery in certain people.
Los Angeles, CaliforniaAges 18–75 - NCT05170815Recruiting
Spine Device Registry for Adults Getting Commercial Devices
This study is a registry that collects information about adults who use specific, commercially available spine devices. It may help doctors understand how these devices are used in real-world care and what outcomes look like over time.
LyonAges 18 years+ - NCT04140344Recruiting
Study texting messages after low back fusion surgery
This study tests whether regular text-message check-ins after lumbar (low back) fusion surgery are helpful for communication and follow-up. It enrolls people who will be getting their first low back fusion and who are comfortable texting and willing to stay in regular contact.
Durham, North CarolinaAges 18 years+ - NCT05527145Recruiting
Non-surgical spacer for spinal stenosis causing leg pain
This trial tests a minimally invasive (“through the skin”) procedure that places a small spacer between back bones to relieve lumbar spinal stenosis symptoms like leg pain when walking. It may help people who still need surgery based on their symptoms and MRI findings but may be treated without open surgery.
RomeAges 50–85 - NCT07001969Enrolling by invitation
Percutaneous facet spine fixation for instability
This study tests a minimally invasive procedure to fix unstable vertebrae in the neck or lower back using a small incision. It may help people with spinal instability causing nerve symptoms or pressure on the spinal cord.
Cairo, ShoroukAges Any age - NCT07396077Recruiting
Pre-op health boost for elderly spine surgery patients
This trial tests if a 6-week prehabilitation program (exercise and nutrition) before spine surgery helps elderly patients recover better. It is for people 75 or older with long-term lower back problems who need spinal fusion surgery.
Beijing, Beijing MunicipalityAges 75 years+ - NCT05452694Recruiting
Personalized pain relief after back fusion surgery
This trial tests a personalized plan to manage pain after lumbar (lower back) fusion and decompression surgery. It may help reduce difficult pain while guiding safe use of opioids around the time of surgery.
Pittsburgh, PennsylvaniaAges 18–99 - NCT06462729RecruitingPhase 1/Phase 2
Testing a new bone graft for lower back fusion surgery
This trial tests a new bone graft material called LDGraft for people who need a single-level lower back fusion (anterior lumbar interbody fusion). It aims to see if the new graft is as good as or better than current options for helping bones heal together.
Fort Wayne, IndianaAges 22–80 - NCT05817747Recruiting
Using big data to predict outcomes after spine surgery
This study collects information from people having surgery for problems in the lower (lumbar) or neck (cervical) spine. It tests whether using “big data” from routine care can help predict surgical outcomes and improve future decisions.
Ängelholm, Skåne CountyAges 18 years+ - NCT04467944Recruiting
Lumbar fusion outcomes with arthritis in nearby spine segments
This study looks at how well lumbar fusion surgery works long-term when the joint just above or below (adjacent segment) already shows wear-and-tear. It may help predict who benefits most and guide treatment planning.
Beijing, Beijing MunicipalityAges 18–80 - NCT05332249Recruiting
Registry for Degenerative Spine Disease in the Neck and Low Back
This study is a registry (a way to collect health information) for people with wear-and-tear (“degenerative”) problems in the neck and/or low back. It may help doctors better understand these conditions and improve future care plans.
Seoul, KoreaAges 18–100 - NCT06202443Recruiting
Physical therapy timing after neck surgery
This study looks at whether starting physical therapy soon after ACDF neck surgery helps people recover better. It compares early physical therapy to standard care.
Honolulu, HawaiiAges 18–75 - NCT06407427Recruiting
Mobile app for recovery after hip, knee, or spine surgery
This study tests whether a mobile app can help with physical therapy after common bone or joint surgeries. You may qualify if you recently had a hip fracture, hip or knee replacement, or spine surgery without paralysis. The app guides your exercises at home.
New Haven, ConnecticutAges 18 years+ - NCT04469387Recruiting
Reduce adjacent back pain after lumbar surgery
This trial looks at whether a limited decompression (a careful nerve-space “freeing” procedure) can help prevent future problems in the spinal level next to your planned surgery. It targets people with spinal canal narrowing next to the surgery level but who do not yet have symptoms there.
Beijing, Beijing MunicipalityAges 18–80 - NCT07026552Recruiting
Ligament study for lumbar spinal stenosis
This study looks at the ligament in your lower back to understand how lumbar spinal stenosis develops. It involves analyzing tissue samples and may help find better ways to treat this condition.
Rome, RMAges 50–85 - NCT06475365Enrolling by invitation
Salt water gargling after neck surgery to help swallowing
This study tests whether gargling with salt water after multi-level neck fusion surgery can improve swallowing recovery. If you are having this surgery, the trial aims to find a simple, low-cost way to protect your swallowing function.
Los Angeles, CaliforniaAges 18–80 - NCT05981222Enrolling by invitation
Osteo Match vs. PEEK cages for spinal fusion in osteoporosis
This study compares two types of cages used in spinal fusion surgery for people with osteoporosis. It aims to see if one type leads to better bone healing and stability.
Beijing, Beijing MunicipalityAges 50 years+ - NCT07139938Recruiting
Spinal decompression without implants for lumbar stenosis
This trial tests whether removing pressure on spinal nerves alone, without any hardware, can help fix spine balance and reduce pain in people with lumbar stenosis. It is for those who have had leg pain or trouble walking for at least 3 months and plan to have surgery without implants.
MoscowAges 18 years+ - NCT03076658Recruiting
Standing full-body X-rays from healthy adults
This trial is building a database of full-body standing X-rays in people who do not have spine problems or certain health conditions. If you qualify, your X-rays may help researchers study normal body alignment for future medical use.
Aurora, ColoradoAges 21–85 - NCT07261553Recruiting
Exercises at home for muscle and bone conditions
This study looks at how well people follow a home exercise program for muscle or bone problems. It aims to understand what helps or makes it hard to stick with the exercises.
Konya, KonyaAges 18 years+ - NCT07133724Recruiting
Digital health study for lumbar spine wear and tear
This study uses digital tools to measure how lumbar degeneration affects walking. It aims to find early signs of spine problems in people without current back pain.
TaipeiAges 50–80 - NCT01788410Recruiting
MRI-guided freezing treatment for neck, head, and spine pain
This trial studies an MRI-guided procedure that “freezes” targeted nerves or joints to reduce pain in the head, neck, or spine. It may help if your pain comes from a joint problem or a compressed/damaged nerve and you can safely have MRI scans before and after the treatment.
Boston, MassachusettsAges 18 years+ - NCT06603831Recruiting
3D digital surgery study for bone and joint procedures
This study tests whether 3D digital planning tools make surgeries for certain bone and joint problems more effective and cost-efficient. If you need a specific type of surgery on your forearm, pelvis, or spine, this trial could help determine if digital surgery improves your recovery.
Sabadell, BarcelonaAges 18–80 - NCT05110833Enrolling by invitation
Study dosing effects during monitored neck or chest spine surgery
This trial studies whether different medication dosing during monitored neck or upper chest spine surgery leads to better outcomes. You might help doctors figure out the most effective dosing approach for this type of surgery.
Minneapolis, MinnesotaAges 18 years+
Hear when a new Spine Degeneration trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for spine degeneration?
- Yes. Clin2 currently lists 31 recruiting spine degeneration studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a spine degeneration trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a spine degeneration trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.