Clinical trials
Schizophrenia / Schizoaffective Disorder clinical trials
Below are recruiting schizophrenia / schizoaffective disorder clinical trials, each written for real people, not researchers. We’re tracking 81 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07130500Enrolling by invitation
Rewards for sticking with long-acting injections
This study tests whether offering small rewards (like gift cards) can help people stick with a long-acting injection of their medication. It's for people with serious mental health conditions who have had a recent hospital stay or are at high risk of one.
Pittsburgh, PennsylvaniaAges 18–65 - NCT04629352Recruiting
tDCS brain-stimulation for hearing voices in schizophrenia
This study tests whether a non-invasive brain-stimulation treatment (tDCS) can improve response to care in people who experience clinically significant hearing voices. It may help by changing brain activity, aiming to reduce or improve auditory hallucinations.
Bengaluru, KarnatakaAges 18–45 - NCT05208190RecruitingPhase 4
Clozapine to prevent violence in schizophrenia
This trial tests whether clozapine can reduce repeat violent behavior in people with schizophrenia or schizoaffective disorder. Participants are randomly assigned to clozapine or usual care to see which approach works better for preventing violence.
Los Angeles, CaliforniaAges 18–65 - NCT06376734RecruitingPhase 2
TMS for depression, anxiety, OCD, or schizophrenia
This study tests whether a brain stimulation technique called TMS can help people with depression, anxiety, OCD, or schizophrenia. It aims to find better ways to target the treatment for each person's specific needs.
Sunnyvale, CaliforniaAges 18–65 - NCT06729541Recruiting
Precision treatments for common mental disorders
This study is developing more personalized treatments for schizophrenia, depression, or bipolar disorder. It may help find the best treatment approach for your specific situation.
Beijing, Beijing MunicipalityAges 18–65 - NCT07434479Recruiting
Virtual reality mindfulness for aggression in schizophrenia
This study tests whether a virtual reality mindfulness program can help people with schizophrenia who have problems with impulsive aggression. You would use a VR headset for relaxation exercises and answer questions about your mood and behavior.
New York, New YorkAges 18–64 - NCT03495024RecruitingPhase 4
Varenicline for quitting smoking in people with schizophrenia
This trial tests whether varenicline helps people with schizophrenia or schizoaffective disorder stop smoking. It also looks at related nervous-system side effects that can happen with some anti-psychotic medicines.
Philadelphia, PennsylvaniaAges 18–75 - NCT06745479Recruiting
Understanding decision-making in schizophrenia with brain scans
This study uses brain scans and real-life surveys to understand how people with or without schizophrenia make decisions. It may help researchers learn how the brain works differently in schizophrenia.
Piscataway, New JerseyAges 18–50 - NCT06740890RecruitingPhase 4
Exercise and a new medication for schizophrenia or bipolar disorder
This study tests whether a combination of a daily medication (olanzapine-samidorphan) and a structured exercise program can help people with schizophrenia, schizoaffective disorder, or bipolar disorder improve their health and well-being.
New York, New YorkAges 18–65 - NCT05064319RecruitingPhase 2
Gabapentin for bipolar symptoms with heavy cannabis use
This Phase 2 study tests whether gabapentin can help balance brain chemicals (GABA and glutamate) in people with bipolar disorder and cannabis use disorder. If you meet criteria, you may be able to try gabapentin while closely monitoring mood, safety, and cannabis use.
Charleston, South CarolinaAges 18–65 - NCT05805397Recruiting
Motivation skills training for schizophrenia or schizoaffective disorder
This study tests whether “Motivation Skills Training” can help people with schizophrenia or schizoaffective disorder. It’s for people who are stable on treatment and can participate in English-speaking sessions.
New York, New YorkAges 18–65 - NCT06286202Recruiting
Cognitive skills program for schizophrenia recovery
This trial tests a community-based program called INSPIRE that uses mental exercises and social coaching to help people with schizophrenia or schizoaffective disorder improve their thinking skills and daily functioning. It is conducted in English and requires at least 10 years of English-language education.
SingaporeAges 21–60 - NCT07058389Recruiting
Exercise in green spaces for schizophrenia symptoms
This study tests whether combining physical activity with being in green outdoor spaces can reduce the tough symptoms of schizophrenia, like feeling flat or unmotivated. It's designed for people whose negative symptoms are not going away.
Saint-Etienne, FranceAges 18–55 - NCT01409109Recruiting
Study database for brain signal markers in psychosis
This study builds a database of brain-signal measurements to help find “biomarkers” that may point to schizophrenia or related mental illnesses. Depending on whether you have a mental health diagnosis or you’re healthy, the study will collect information and brain data to compare groups.
Dallas, TexasAges 18–60 - NCT07423546RecruitingPhase 1/Phase 2
Brain scan study of Cobenfy in schizophrenia
This study tests a new medication called Cobenfy (also known as trospium) using brain scans to see how it affects dopamine in people with schizophrenia. If you have schizophrenia and are not currently on antipsychotics, you may be able to join.
New York, New YorkAges 18–50 - NCT07408934Enrolling by invitation
Group therapy for feeling safer with psychosis
This trial tests a group therapy program called the Feeling Safe Programme for people with psychosis. It aims to help you learn new ways to cope with your symptoms and feel safer. It meets once a week for 75 minutes.
Ottawa, OntarioAges 18 years+ - NCT05157620Recruiting
Yoga and exercise program for veterans with severe mental illness
This trial tests an exercise and yoga-style wellness program to help veterans with severe mental health conditions feel and function better. It may help with symptoms and overall well-being, especially if your condition is currently stable.
Pittsburgh, PennsylvaniaAges 18–70 - NCT05349513Recruiting
Testing a home-care program for schizophrenia-like disorders
This study tests a specific kind of care delivered in a home-like setting for people with schizophrenia or schizoaffective disorder. It may help the care team understand what kinds of supports work best and improve day-to-day treatment.
PoitiersAges 18–65 - NCT05303064RecruitingPhase 3
Study of weight gain medicine for teens with certain mood or psychosis
This Phase 3 study tests a treatment aimed at reducing unhealthy weight gain in teens with schizophrenia or bipolar I disorder, using changes in BMI (a height-and-weight measure). It may help families who are concerned about weight changes that can happen with some psychiatric medicines.
Dothan, AlabamaAges 10–17 - NCT06586164Recruiting
Rehabilitation research for veterans with serious mental illness
This study is testing a new rehabilitation program for veterans with serious mental illness, like schizophrenia, bipolar disorder, or PTSD. If you join, you will help researchers see if this program improves daily functioning and quality of life.
San Diego, CaliforniaAges 18–83 - NCT06191965RecruitingPhase 2/Phase 3
MitoQ supplement for early psychosis
This study tests whether a supplement called MitoQ can help people with early-stage psychosis by improving how their cells produce energy. If you are younger and have been treated for psychosis for less than 5 years, this trial may be an option for you.
New Haven, ConnecticutAges 18–35 - NCT07755605Recruiting
Smartphone app training for social skills in schizophrenia
This trial tests a smartphone app designed to help people with schizophrenia or schizoaffective disorder improve their social thinking and interactions. It may be a good option if you can use an app and are on stable medication.
SeoulAges 19–60 - NCT05698589Recruiting
Therapy program to reduce self-stigma in mental health
This study looks at how a program may help people with long-term mental health conditions feel less shame about their diagnosis (self-stigma). It is meant for adults who are stable enough to participate and who speak French.
BordeauxAges 18 years+ - NCT04323566Enrolling by invitationPhase 2
Rituximab for OCD or psychosis linked to immune inflammation
This trial tests rituximab (an immune system medicine) to see if it can reduce OCD symptoms and/or psychosis when there are signs the immune system may be involved. You may be considered if other standard psychiatric treatments have not helped enough and your illness seems relatively recent with possible inflammation clues.
UppsalaAges 18–55
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Common questions
- Are there clinical trials for schizophrenia / schizoaffective disorder?
- Yes. Clin2 currently lists 81 recruiting schizophrenia / schizoaffective disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a schizophrenia / schizoaffective disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a schizophrenia / schizoaffective disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.