Clinical trials
Schizophrenia / Schizoaffective Disorder clinical trials
Below are recruiting schizophrenia / schizoaffective disorder clinical trials, each written for real people, not researchers. We’re tracking 83 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06191965RecruitingPhase 2/Phase 3
MitoQ supplement for early psychosis
This study tests whether a supplement called MitoQ can help people with early-stage psychosis by improving how their cells produce energy. If you are younger and have been treated for psychosis for less than 5 years, this trial may be an option for you.
New Haven, ConnecticutAges 18–35 - NCT05698589Recruiting
Therapy program to reduce self-stigma in mental health
This study looks at how a program may help people with long-term mental health conditions feel less shame about their diagnosis (self-stigma). It is meant for adults who are stable enough to participate and who speak French.
BordeauxAges 18 years+ - NCT04323566Enrolling by invitationPhase 2
Rituximab for OCD or psychosis linked to immune inflammation
This trial tests rituximab (an immune system medicine) to see if it can reduce OCD symptoms and/or psychosis when there are signs the immune system may be involved. You may be considered if other standard psychiatric treatments have not helped enough and your illness seems relatively recent with possible inflammation clues.
UppsalaAges 18–55 - NCT05603104RecruitingPhase 3
Medication intensification after first treatment failure in mood and psychosis
This Phase 3 study tests a stronger medication approach after your first current treatment hasn’t worked well enough. It targets people with schizophrenia, major depressive disorder, or bipolar depression who still have significant symptoms and life impact.
Ramat GanAges 18–70 - NCT06865937Recruiting
A mobile app to help with social recovery in serious mental illness
This study tests a mobile app that provides support for social recovery in people with serious mental illness. It may help you feel less isolated and more connected.
San Diego, CaliforniaAges 18–65 - NCT06758414Recruiting
CBT for chronic pain in veterans with serious mental illness
This trial tests a type of talk therapy called Cognitive Behavioral Therapy for Chronic Pain, designed for veterans with serious mental illness. It aims to help you manage back pain and improve your quality of life.
Baltimore, MarylandAges 18 years+ - NCT07055204Recruiting
Music-based cognitive training for schizophrenia
This study tests a special music-based training program that uses rhythm, voice, and body movements to help with thinking and memory skills in people with schizophrenia. It might improve how your brain processes information.
BayonneAges 18–60 - NCT06641297Recruiting
Brain Wiring Study in Schizophrenia
This study uses MRI scans to look at brain changes in people with schizophrenia. It aims to understand how the brain's wiring (called white matter) changes over time.
Catonsville, MarylandAges 15–45 - NCT05491538Recruiting
Work-focused social skills training for veterans with mental illness
This study tests a program to help veterans with serious mental illness improve social skills for work and find jobs near the VA. It aims to see if the program is acceptable and feasible for participants.
Minneapolis, MinnesotaAges 18 years+ - NCT04414215Recruiting
Emotion-focused brain training for schizophrenia or schizoaffective disorder
This study tests a structured cognitive (thinking/skill) training program aimed at improving how people manage emotions. It may help by teaching emotion regulation skills alongside existing care.
Athens, GeorgiaAges 18–60 - NCT05934474Recruiting
Study collects blood to learn about inflammation in mental illness
This study collects biological samples to better understand how “inflammation” in the body may relate to certain mental health conditions. Your results may help doctors learn more about causes and future treatments, even if the study does not give a new drug.
NantesAges 18 years+ - NCT06872463Recruiting
Karolinska Schizophrenia Project: Brain study for first episode psychosis
This study examines the brain in people having their first episode of psychosis (like hearing voices or strong false beliefs) to understand more about schizophrenia and related conditions. It involves MRI scans and other tests over one year.
StockholmAges 18 years+ - NCT07419321Recruiting
Social isolation and aging in schizophrenia study
This study looks at how social isolation affects aging in people with schizophrenia. It may help researchers understand more about the health and well-being of older adults with this condition.
Hartford, ConnecticutAges 40–70 - NCT06174116RecruitingPhase 4
Adding lumateperone to clozapine for schizophrenia
This trial tests whether adding lumateperone, an antipsychotic medication, to clozapine can improve metabolic health in people with schizophrenia. It aims to see if this combination helps with weight, blood sugar, and cholesterol levels.
Worcester, MassachusettsAges 18–65 - NCT05343598Recruiting
Using TMS to study hallucinations in schizophrenia
This study uses a non-invasive brain stimulation method (TMS) along with brain scans (MRI) to better understand why hallucinations happen in schizophrenia. It may help researchers learn more about brain processes involved, which could guide future treatments.
Belmont, MassachusettsAges 18–55 - NCT03794076RecruitingPhase 1/Phase 2
Testing adjunct cromoglicate for schizophrenia symptoms
This trial studies whether adding cromoglicate to your usual antipsychotic medicine can improve schizophrenia symptoms. It’s designed for outpatients who are already on a stable treatment and still have certain ongoing symptom scores.
Pittsburgh, PennsylvaniaAges 18–65 - NCT07680114Recruiting
Overnight brain stimulation for sleep in schizophrenia
This study tests a gentle overnight brain stimulation technique to improve sleep spindles—brain waves that help with memory—in people with schizophrenia or related disorders. It may help understand how sleep affects thinking and symptoms.
Madison, WisconsinAges 18–50 - NCT07006935Recruiting
Clubhouse program effects on recovery and brain health
This study looks at how Clubhouse programs (a type of community-based support) affect thinking and brain health in people with schizophrenia or related conditions. It compares Clubhouse participation to usual care. If eligible, you would complete thinking tests and possibly an MRI brain scan.
Cleveland, OhioAges 18–50 - NCT06118268Recruiting
Brain stimulation to improve social thinking in psychosis
This study tests whether a type of brain stimulation called intermittent theta burst stimulation (iTBS) can help improve social thinking and understanding in people with psychosis. Researchers want to see if this treatment can boost how you read social cues and connect with others.
Glen Oaks, New YorkAges 18–39 - NCT05671185Recruiting
Brain stimulation for schizophrenia symptoms and depression
This study tests repeated brain stimulation (rTMS) to see if it can improve symptoms of schizophrenia and related depression, and measure body/brain changes. You may be considered if you have schizophrenia or schizoaffective disorder with enough depressive symptoms, and if recent treatments and medical safety factors fit the rules.
Douliu, YunlinAges 20 years+ - NCT07185815RecruitingPhase 1/Phase 2
Study of a long-acting cariprazine shot for mood and schizophrenia
This trial tests a monthly injection of cariprazine (a medication for mental health conditions) in people who could benefit from it. It aims to see if the shot is safe, tolerable, and effective compared to taking pills every day.
AhmedabadAges 18–64 - NCT04278339Recruiting
Brain and behavior study of empathy in schizophrenia
This study looks at brain signals and behavioral measures to understand empathy-related processes in people with schizophrenia or schizoaffective disorder. It may help researchers better understand what’s happening in the brain and how it relates to feelings and social understanding.
NiceAges 18–60 - NCT06978803Recruiting
Speech and brain study for early psychosis
This study looks at how people with early psychosis (within the first 5 years of treatment) talk during conversations. Researchers hope to learn more about speech patterns and brain activity related to psychosis.
Montreal, QuebecAges 18–60 - NCT06835556Recruiting
Studying paranoia changes with talk therapy
This trial tests how a type of talk therapy affects paranoia in people with schizophrenia or related conditions. It aims to understand if daily changes in paranoia can improve with treatment.
Nashville, TennesseeAges 18–65
Hear when a new Schizophrenia / Schizoaffective Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for schizophrenia / schizoaffective disorder?
- Yes. Clin2 currently lists 83 recruiting schizophrenia / schizoaffective disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a schizophrenia / schizoaffective disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a schizophrenia / schizoaffective disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.