Clinical trials
Sentinel Lymph Node clinical trials
Below are recruiting sentinel lymph node clinical trials, each written for real people, not researchers. We’re tracking 95 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04019678Recruiting
Breast cancer study after chemotherapy with small underarm node spread
This study looks at whether it’s safe and effective to avoid removing many underarm lymph nodes in some people who, after chemotherapy, still seem to have only tiny (“micro”) cancer deposits in the sentinel lymph node. It may help reduce treatment side effects while keeping cancer control.
Rozzano, MIAges 18–75 - NCT04293796Recruiting
Skipping breast surgery after complete response
This trial looks at whether some people with breast cancer can safely avoid breast surgery after they respond completely to treatment before surgery. If you have no remaining cancer in the tissue and lymph node tests, this study checks whether the “watch-and-wait” approach is feasible and safe.
Saint PetersburgAges 18–70 - NCT04741737Recruiting
Repeat lymph node biopsy for recurrent breast cancer
This study tests whether repeating a specific lymph node biopsy (sentinel lymph node biopsy) is safe and useful in people whose breast cancer has come back in the same breast. It may help doctors better understand whether lymph nodes are involved and guide next steps after surgery.
SeoulAges 19 years+ - NCT06259513Recruiting
Skipping armpit surgery for breast cancer patients
This trial tests whether it's safe to skip armpit surgery in older women with small, low-risk breast cancers. If you qualify, you would have a mastectomy without removing lymph nodes from your armpit.
SingaporeAges 21–80 - NCT06321653Recruiting
Lymphedema after radiation for early breast cancer with 1-2 positive nodes
This trial aims to see if a shorter course of radiation after breast-conserving surgery affects arm swelling (lymphedema) in people with early breast cancer that has spread to 1 or 2 nearby lymph nodes. The goal is to learn if this approach is safe and effective.
MilanAges 18 years+ - NCT07844473Recruiting
Magtrace dye to guide surgery for early breast cancer
This trial tests using a special dye called Magtrace to help surgeons find and remove the cancer and check nearby lymph nodes during breast-conserving surgery. It might help make the surgery more precise and avoid extra procedures.
MadinahAges 18 years+ - NCT07708012Recruiting
Laparoscopic and endoscopic surgery for early stomach cancer
This study tests a less invasive surgery for early stomach cancer that combines a camera in the belly with a scope down the throat. It aims to remove the cancer while saving as much of the stomach as possible, which may mean a quicker recovery and better quality of life.
Qingdao, ShandongAges 18–80 - NCT06656949Recruiting
ICG injection for lymph node mapping in endometrial cancer
This trial tests whether injecting a dye called indocyanine green (ICG) in different spots can better find sentinel lymph nodes during surgery for endometrial cancer. It may help doctors remove fewer nodes and reduce side effects.
Jinan, ShandongAges 18–80 - NCT07621614RecruitingPhase 2
Safe Surgery Guidance for Childhood Melanoma Using Genetics
This study helps doctors decide the safest surgical approach for melanoma and similar skin tumors in children and young adults by using pathology reports and genetic information. The goal is to avoid unnecessary surgery while ensuring the best outcomes.
Oakland, CaliforniaAges Up to 25 years - NCT06713161Recruiting
New dye to spot breast cancer during surgery
This study tests a special dye that helps surgeons see breast cancer tissue and nearby lymph nodes more clearly during surgery. The goal is to make sure all cancer is removed while sparing healthy tissue.
Kunming, YunnanAges 18–75 - NCT07380698Recruiting
ICG dose and storage for lymph node mapping in gynecologic cancer
This trial looks at how the dose and storage of a dye called indocyanine green (ICG) affects its ability to find sentinel lymph nodes during surgery for gynecologic cancers like cervical, endometrial, and vulvar cancer. The goal is to make the procedure both more effective and more affordable.
AdanaAges Any age - NCT07294638Recruiting
New imaging method to find cancer spread in early gastric cancer
This trial tests a new dye that helps surgeons see if early gastric cancer has spread to nearby lymph nodes. It might help guide the extent of surgery needed.
Guangzhou, GuangdongAges 18 years+ - NCT07278726Recruiting
Targeted removal of only suspicious lymph nodes for early breast cancer
This trial is testing a targeted surgical approach to remove only the suspicious lymph nodes under the arm for people with early-stage, hormone receptor positive, HER2 negative breast cancer. The goal is to see if this less extensive surgery is safe and effective when there is limited lymph node involvement.
Bologna, ItalyAges 18–90 - NCT06911528Recruiting
New cell-probing technology for early breast cancer surgery
This trial tests a new technology that helps doctors examine cells during surgery for early-stage breast cancer. It may help make the sentinel lymph node biopsy more accurate.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07068074RecruitingPhase 3
Comparing less invasive surgery to standard care for older adults with early-stage melanoma
This trial compares less invasive procedures with the current standard treatment for early-stage melanoma in adults 75 and older. The goal is to find out if these less invasive options work just as well and help patients recover better.
Birmingham, AlabamaAges 75 years+ - NCT06935305Recruiting
Testing a faster method to find cancer in sentinel lymph nodes
This trial compares a fast lab test (OSNA) with standard microscope checks to see which better finds cancer in the first lymph node (sentinel node) during surgery for early-stage endometrial cancer. It aims to improve accuracy and speed while avoiding unnecessary lymph node removal.
Rome, ItalyAges Any age - NCT06768268Enrolling by invitationPhase 1/Phase 2
Better lymph node imaging for breast cancer
This trial tests whether adding two common fluids (Mannitol and Voluven) before an ICG dye injection can help surgeons better see the lymph nodes that need to be removed during breast cancer surgery. It aims to make sentinel lymph node biopsies more accurate and safer.
Hsinchu CountyAges 20–70 - NCT06689956Recruiting
Observation after surgery for low-risk endometrial cancer with tiny lymph node findings
This study looks at women with low-risk endometrial cancer who had tiny amounts of cancer cells found in their sentinel lymph nodes during surgery. Doctors want to see if it's safe to avoid additional treatments like chemotherapy or radiation.
Rochester, MinnesotaAges Any age - NCT06610539Recruiting
Magnetic tracer for sentinel node biopsy in breast cancer
This study tests a magnetic tracer call Magtrace to help find and remove the first lymph node (sentinel node) during breast cancer surgery. The goal is to see if it works well for people having breast-conserving surgery.
Chapel Hill, North CarolinaAges 18 years+ - NCT06444269RecruitingPhase 2
Precision radiation before surgery for early hormone-positive breast cancer
This trial tests a focused radiation treatment before surgery for early-stage breast cancer that is hormone receptor positive and HER2 negative. The goal is to give precise radiation only to the tumor, with the hope of reducing side effects and improving outcomes.
Dallas, TexasAges 18 years+ - NCT06216938RecruitingEarly Phase 1
RP1 virus therapy for advanced melanoma to lower lymph node spread risk
This trial tests a new kind of virus-based treatment (RP1) given directly into melanoma tumors to see if it can reduce the chance of cancer spreading to nearby lymph nodes. It's for people with thicker or more advanced skin melanoma that still has visible tumor or positive margins after biopsy.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT03097575RecruitingPhase 1/Phase 2
Imaging-guided lung surgery using special near-infrared light
This trial tests whether using special near-infrared imaging can help surgeons better guide lung tumor removal during minimally invasive or open chest surgery. It may improve how accurately the surgical area is identified during the operation.
Boston, MassachusettsAges 18 years+ - NCT06039111Recruiting
Comparing two dyes for lymph node mapping in vulvar cancer
This study compares two methods for finding the first lymph node (sentinel node) that may contain cancer in people with vulvar cancer. It uses a dye called indocyanine green alone or with a radioactive tracer (technetium) to see which approach works better for staging the disease.
Hamilton, OntarioAges 18 years+ - NCT05763641Recruiting
Targeted treatment after chemo for certain breast cancers
This trial studies an additional treatment given after chemotherapy for locally advanced breast cancer that has spread to specific underarm lymph nodes. It may help some people reduce cancer returning, especially when tumors match certain growth and spread features.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+
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Common questions
- Are there clinical trials for sentinel lymph node?
- Yes. Clin2 currently lists 95 recruiting sentinel lymph node studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sentinel lymph node trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sentinel lymph node trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.