Clinical trials
Sentinel Lymph Node clinical trials
Below are recruiting sentinel lymph node clinical trials, each written for real people, not researchers. We’re tracking 94 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06935305Recruiting
Testing a faster method to find cancer in sentinel lymph nodes
This trial compares a fast lab test (OSNA) with standard microscope checks to see which better finds cancer in the first lymph node (sentinel node) during surgery for early-stage endometrial cancer. It aims to improve accuracy and speed while avoiding unnecessary lymph node removal.
Rome, ItalyAges Any age - NCT07294638Recruiting
New imaging method to find cancer spread in early gastric cancer
This trial tests a new dye that helps surgeons see if early gastric cancer has spread to nearby lymph nodes. It might help guide the extent of surgery needed.
Guangzhou, GuangdongAges 18 years+ - NCT07380698Recruiting
ICG dose and storage for lymph node mapping in gynecologic cancer
This trial looks at how the dose and storage of a dye called indocyanine green (ICG) affects its ability to find sentinel lymph nodes during surgery for gynecologic cancers like cervical, endometrial, and vulvar cancer. The goal is to make the procedure both more effective and more affordable.
AdanaAges Any age - NCT06768268Enrolling by invitationPhase 1/Phase 2
Better lymph node imaging for breast cancer
This trial tests whether adding two common fluids (Mannitol and Voluven) before an ICG dye injection can help surgeons better see the lymph nodes that need to be removed during breast cancer surgery. It aims to make sentinel lymph node biopsies more accurate and safer.
Hsinchu CountyAges 20–70 - NCT07140172Recruiting
Radiation or surgery for node-positive breast cancer
This trial compares two treatments for people with breast cancer that has spread to the lymph nodes: radiation therapy to the armpit or surgery to remove the lymph nodes. The goal is to see which approach works best after a tailored surgery to remove the most suspicious lymph nodes.
Bethesda, MarylandAges 18 years+ - NCT07304934Recruiting
New blood test model to check lymph node status in breast cancer
This study uses a blood test and imaging to predict whether breast cancer has spread to underarm lymph nodes, helping guide surgery. It may reduce unnecessary lymph node removal.
Hangzhou, ZhejiangAges 18 years+ - NCT05912569Recruiting
Test a delayed sentinel lymph node biopsy during mastectomy for DCIS
This trial tests whether doing a “sentinel lymph node biopsy” later (a delayed biopsy) can help assess whether cancer has spread to lymph nodes in people having a mastectomy for DCIS. It may help avoid unnecessary aggressive treatment if lymph nodes look normal.
SeoulAges 20–75 - NCT05976412Recruiting
Radiation to lymph nodes after surgery for higher-risk breast cancer
This trial looks at whether adding targeted radiation to lymph nodes after breast surgery can lower the chance of breast cancer coming back in people with higher-risk, node-negative disease. If you qualify, you may get a planned radiation approach designed for prevention, not treatment of spread.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07131566Recruiting
Immune response in neck lymph nodes in head and neck cancer
This study looks at how the immune system in the lymph nodes of the neck responds to head and neck cancer. It will help researchers understand how the body fights these cancers, which could lead to better treatments.
Stockholm, Stockholm CountyAges 18 years+ - NCT05634889Recruiting
Personalized breast radiation for limited lymph-node spread
This trial studies a tailored form of radiation treatment for some people with early breast cancer whose sentinel lymph-node biopsy shows cancer in 1–2 nodes. It may help improve local control while guiding the best radiation approach for your specific situation.
HelsinkiAges 18 years+ - NCT03545256Recruiting
Outpatient surgery to map lymph nodes in mouth and throat cancer
This trial studies a planned, same-day (outpatient) surgery approach to find and check cancer spread to nearby lymph nodes in early-stage mouth and throat squamous cell cancer. It may help doctors remove the right lymph nodes and decide on any needed further treatment.
Montpellier, HéraultAges 18 years+ - NCT05625373RecruitingPhase 2/Phase 3
Antibiotic powder during groin surgery to prevent infection
This trial studies whether placing an antibiotic powder (vancomycin) directly in the surgical wound during groin lymph node surgery can lower the risk of surgical site infections. It may help reduce wound infections after surgery for vulvar dysplasia.
Providence, Rhode IslandAges 18 years+ - NCT04072653Recruiting
Sentinel node biopsy versus watchful waiting after PET
This trial studies whether taking a sample from the sentinel lymph node (a first lymph node that can be involved) improves care compared with observation, after a breast cancer PET scan of the armpit area. It may help people with certain early breast cancers avoid unnecessary procedures if the lymph nodes look negative on scans.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT04665882Recruiting
Prediction tool for arm swelling after breast cancer surgery
This trial tests a prediction tool (a “nomogram”) to estimate who is at risk of developing breast cancer–related lymphedema, or long-term arm swelling, after surgery. If you fit the surgery and lymph node criteria, your information may help personalize follow-up and prevention.
Wuhan, HubeiAges 18–80 - NCT05937620Recruiting
Mapping ovarian cancer sentinel nodes with two injected dyes
This study checks whether doctors can find the first lymph node(s) where ovarian cancer may spread using two dyes (a radioactive tracer and a green dye). It may help surgeons do more precise staging and treatment planning.
Barcelona, CataloniaAges 18 years+ - NCT06104371Recruiting
Magnetic markers to find lymph nodes before chemo for breast cancer
This trial tests a new method using magnetic markers (Magtrace and Magseed) to find lymph nodes before chemotherapy. It may help doctors better target the lymph nodes that need to be removed during breast cancer surgery.
GothenburgAges 18–85 - NCT06378944Recruiting
Gentle lymph node check for breast cancer
This trial tests a way to check lymph nodes in the armpit using a special green dye. It is for people with breast cancer who need to know if their cancer has spread to these nodes.
Cerdanyola del Vallès, BarcelonaAges 18–120 - NCT07527689Recruiting
Faster vs. Standard Radiation After Breast Cancer Surgery
This study compares two radiation schedules for breast cancer patients at high risk of cancer returning in lymph nodes. Both use modern radiation therapy, but one delivers treatment faster (ultra-hypofractionated) while the other uses a more moderate schedule. The goal is to see which approach works better with fewer side effects.
ShanghaiAges 18 years+ - NCT07469267Recruiting
Armpit radiation vs more surgery for early breast cancer with node spread
This trial tests whether radiation to the lower armpit (level I-II axilla) works as well as more extensive surgery for women with early-stage breast cancer that has spread to one or two sentinel lymph nodes (with cancer size > 2 mm). It aims to find a gentler treatment that still keeps the cancer from coming back.
Guiyang, GuizhouAges 18 years+ - NCT07546695Recruiting
Axillary lymph node surgery choices for HER2+ and triple-negative breast cancer
This study examines the best surgical approach for removing underarm lymph nodes in patients with HER2-positive or triple-negative breast cancer who have received chemotherapy before surgery and still have cancer in their lymph nodes. The goal is to understand whether removing more lymph nodes improves outcomes for these patients.
BaselAges Any age - NCT07483034Enrolling by invitation
Music therapy for anxiety during breast cancer treatment
This study tests whether listening to specially chosen music while you're in the hospital for breast cancer treatment can help lower anxiety and depression. It also looks at how music might affect certain substances in your blood that are linked to stress and healing.
Zagreb, City of ZagrebAges 18–65 - NCT04688528Recruiting
Radiation planning to spare the opposite neck in head cancer
This trial tests a safer radiation plan that may reduce dose to the opposite (other) side of the neck while still treating the cancer spread risk. It uses special mapping to guide treatment and looks at patients whose cancer is already in an involved lymph node on one side.
Genk, LimburgAges 18 years+
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Common questions
- Are there clinical trials for sentinel lymph node?
- Yes. Clin2 currently lists 94 recruiting sentinel lymph node studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sentinel lymph node trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sentinel lymph node trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.