Clinical trials
Sentinel Lymph Node clinical trials
Below are recruiting sentinel lymph node clinical trials, each written for real people, not researchers. We’re tracking 94 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06001528Recruiting
Predicting lymph node spread in breast cancer
This study looks at whether substances called metabolites in your blood and breast tissue can help predict if breast cancer has spread to the first lymph node (sentinel node). If you are scheduled for breast cancer surgery and have not had prior treatment, the study team will use your blood and tissue samples to try to improve prediction.
Shantou, GuangdongAges 18 years+ - NCT06029504Recruiting
Optical-guided sentinel node biopsy for vulvar cancer staging
This trial tests a new optical method using a dye to find and remove the first lymph node (sentinel node) that cancer might spread to, to stage vulvar cancer more accurately. It's for patients with a smaller tumor (under 4 cm) that hasn't been treated in the groin area before.
CopenhagenAges 18 years+ - NCT06085274Recruiting
SHINE: Using a special dye to find lymph nodes after breast cancer chemo
This study tests whether a special dye called indocyanine green (ICG) can help find sentinel lymph nodes during breast cancer surgery after chemotherapy. It may offer a safer and more effective way to check if cancer has spread.
Toronto, OntarioAges 18–80 - NCT06121570RecruitingPhase 1
Study of immune cells from lymph nodes for HER2-negative breast cancer
This trial tests whether using a patient's own immune cells from lymph nodes near the tumor, given as a treatment before surgery, can help shrink HER2-negative breast cancer. It is for people whose cancer has not responded fully to two cycles of initial chemotherapy.
Guangzhou, GuangdongAges 18–70 - NCT06133543Recruiting
Robotic sentinel node biopsy for testicular cancer
This trial uses a robot and a special dye (ICG) to find and remove the first lymph node that might contain cancer cells in men with testicular cancer. It aims to reduce unnecessary lymph node removal while still detecting spread.
DüsseldorfAges 18–99 - NCT06161428Recruiting
Dye-guided lymph node biopsy for vulvar cancer
This trial tests a new way to find and remove the first lymph node that might contain cancer cells in women with large or recurrent vulvar cancer. It uses a special dye to guide the surgeon, which may help improve staging and reduce side effects.
CopenhagenAges 18 years+ - NCT06169072RecruitingPhase 2
Finding lymph nodes with a tiny dose of magnetic tracer in breast cancer
This trial is testing whether a very small amount of a magnetic tracer called Magtrace can help find lymph nodes that need to be checked for cancer spread during breast cancer surgery.
GothenburgAges 18 years+ - NCT06619002Recruiting
Using video to make uterine cancer surgery safer
This study is collecting videos from a type of minimally invasive surgery called sentinel lymph node dissection for endometrial or cervical cancer. The goal is to use deep learning (a type of artificial intelligence) to help surgeons identify important structures and any spread of cancer during the procedure, making the surgery safer and more effective.
RomaAges 18–99 - NCT06652672Recruiting
Sentinel Node and Organ-Sparing Surgery for Early Colon Cancer
This trial tests a less invasive surgery approach for early-stage colon cancer. It uses a special dye to find and remove only the first lymph node (sentinel node) while removing just the part of the colon with the tumor, possibly avoiding a bigger surgery.
AmersfoortAges 18 years+ - NCT06704945RecruitingPhase 3
Skipping armpit surgery after good chemo response
This trial tests whether it's safe to skip armpit surgery in people whose breast cancer has responded well to chemotherapy and whose lymph nodes appear cancer-free on ultrasound. It aims to reduce side effects like arm swelling while still controlling the cancer.
SeoulAges 19 years+ - NCT06780748RecruitingPhase 2
Light-guided re-surgery for recurrent breast cancer
This trial uses a special light and dye to help surgeons find and remove lymph nodes that might contain cancer cells, in women whose breast cancer has come back in the same area after previous surgery.
Goyang-siAges 18 years+ - NCT06788548Recruiting
Fluorescence-Guided Surgery for Early Stomach Cancer
This trial tests a new technique that uses a special dye to highlight the first lymph nodes where stomach cancer might spread, allowing surgeons to remove only the necessary nodes during surgery. The goal is to reduce side effects while still effectively treating the cancer.
Beijing, Beijing MunicipalityAges 18–80 - NCT06963268RecruitingPhase 3
Testing sentinel lymph node surgery for early ovarian cancer
This study tests a way to check for cancer spread in the lymph nodes of the pelvis during surgery for early-stage ovarian cancer. It uses a special dye and tracer to find the first lymph node that drains from the tumor.
Valencia, ValenciaAges 18 years+ - NCT07040657Recruiting
Comparing injection techniques for cervical lymph node mapping in endometrial cancer
This trial tests two different injection methods in the cervix to help map lymph nodes for endometrial cancer. The goal is to find which technique works better for staging, using a dye that helps surgeons see the lymph nodes during surgery.
AnkaraAges 18–75 - NCT07085442Recruiting
Audit of targeted sentinel node biopsy in early breast cancer
This study is checking how well a special type of lymph node biopsy (targeted sentinel node biopsy) works for people with early-stage breast cancer that has spread to just a few lymph nodes. If you are planning breast surgery and meet the specific criteria, this audit will review your results to help improve future care.
BurnleyAges 18 years+ - NCT07121595RecruitingPhase 2
Personalized neck radiation for mouth cancer with sentinel node biopsy
This study tests whether a personalized approach to radiation therapy after surgery, guided by a special lymph node biopsy (sentinel node biopsy), can effectively treat mouth cancer while reducing side effects. It is for people whose cancer is on one side of the mouth and has not spread to the other side of the neck or beyond.
Ann Arbor, MichiganAges 18 years+ - NCT07146295Recruiting
ICG dye to find sentinel nodes in breast cancer surgery
This trial tests using a green dye called ICG (indocyanine green) during breast cancer surgery to find the first lymph nodes (sentinel nodes) that cancer may have spread to. It aims to help doctors locate these nodes more accurately, and is for people with early-stage breast cancer that has not yet spread to the lymph nodes.
AlkmaarAges 18 years+ - NCT07154563Recruiting
Quick test for breast cancer spread to lymph nodes using a new probe
This trial uses a special probe that lights up cancer cells to quickly check if breast cancer has spread to nearby lymph nodes. It may help doctors decide how much surgery is needed.
Kunming, YunnanAges 18–75 - NCT07338721Recruiting
Ultrasound vs. incision for finding sentinel lymph nodes in breast cancer
This trial compares two techniques for finding the first lymph node that breast cancer might spread to (the sentinel node). It tests if using ultrasound guidance through a small axillary incision is better than the standard method.
AntalyaAges 18 years+ - NCT07362485Recruiting
Finding sentinel nodes during mastectomy with dye
This trial tests if a special dye (indocyanine green) can find the first lymph nodes (sentinel nodes) during mastectomy. It may help improve staging for women with early breast cancer who need or choose mastectomy.
Zwolle, OverijsselAges 18 years+ - NCT07441733Recruiting
Using a green dye to map lymph nodes in breast cancer surgery
This trial tests if an injection of indocyanine green dye can help surgeons find and remove only the key lymph nodes in the armpit during breast cancer surgery. It aims to reduce the need for more extensive lymph node removal.
Peschiera del Garda, VeronaAges 18 years+ - NCT07579286Recruiting
Skipping lymph node surgery in early breast cancer
This trial tests whether older women with early-stage, slow-growing breast cancer can safely skip removal of underarm lymph nodes during surgery. The goal is to reduce surgery-related side effects while maintaining safety.
Saint Petersburg, Russian FederationAges 60 years+ - NCT05839912Recruiting
Surgery study for melanoma in one lymph node basin
This trial tests whether removing a clinically involved lymph node basin (via a specific lymph node excision surgery) after certain melanoma findings is helpful. It mainly aims to see effects on outcomes and on arm/leg swelling (lymphedema) after surgery.
Atlanta, GeorgiaAges 18 years+ - NCT07049276Recruiting
Lymph node surgery for melanoma with immunotherapy
This trial tests if a specific type of lymph node surgery, combined with a short course of immunotherapy (medicines that help your immune system fight cancer), works better for melanoma that has spread to nearby lymph nodes. It's for people whose melanoma can be removed and who are healthy enough for treatment.
Los Angeles, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for sentinel lymph node?
- Yes. Clin2 currently lists 94 recruiting sentinel lymph node studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sentinel lymph node trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sentinel lymph node trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.