Clinical trials
Sentinel Lymph Node clinical trials
Below are recruiting sentinel lymph node clinical trials, each written for real people, not researchers. We’re tracking 95 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07362485Recruiting
Finding sentinel nodes during mastectomy with dye
This trial tests if a special dye (indocyanine green) can find the first lymph nodes (sentinel nodes) during mastectomy. It may help improve staging for women with early breast cancer who need or choose mastectomy.
Zwolle, OverijsselAges 18 years+ - NCT07146295Recruiting
ICG dye to find sentinel nodes in breast cancer surgery
This trial tests using a green dye called ICG (indocyanine green) during breast cancer surgery to find the first lymph nodes (sentinel nodes) that cancer may have spread to. It aims to help doctors locate these nodes more accurately, and is for people with early-stage breast cancer that has not yet spread to the lymph nodes.
AlkmaarAges 18 years+ - NCT07154563Recruiting
Quick test for breast cancer spread to lymph nodes using a new probe
This trial uses a special probe that lights up cancer cells to quickly check if breast cancer has spread to nearby lymph nodes. It may help doctors decide how much surgery is needed.
Kunming, YunnanAges 18–75 - NCT07121595RecruitingPhase 2
Personalized neck radiation for mouth cancer with sentinel node biopsy
This study tests whether a personalized approach to radiation therapy after surgery, guided by a special lymph node biopsy (sentinel node biopsy), can effectively treat mouth cancer while reducing side effects. It is for people whose cancer is on one side of the mouth and has not spread to the other side of the neck or beyond.
Ann Arbor, MichiganAges 18 years+ - NCT07080944Recruiting
Lymph node biopsy after chemo for inflammatory breast cancer
This trial is testing if a less invasive sentinel lymph node biopsy can replace more extensive lymph node removal in women with inflammatory breast cancer who have had chemotherapy and whose nodes appear cancer-free. This could help avoid unnecessary side effects.
MilanAges 18 years+ - NCT07040657Recruiting
Comparing injection techniques for cervical lymph node mapping in endometrial cancer
This trial tests two different injection methods in the cervix to help map lymph nodes for endometrial cancer. The goal is to find which technique works better for staging, using a dye that helps surgeons see the lymph nodes during surgery.
AnkaraAges 18–75 - NCT07023601Enrolling by invitation
Study of sentinel node detection in recurrent vulvar cancer
This study tests whether a special dye injection can reliably find the first lymph node that might contain cancer in women whose vulvar cancer has come back for the first time. It aims to help doctors know if the cancer has spread without removing many lymph nodes.
Madrid, MadridAges 18 years+ - NCT06963268RecruitingPhase 3
Testing sentinel lymph node surgery for early ovarian cancer
This study tests a way to check for cancer spread in the lymph nodes of the pelvis during surgery for early-stage ovarian cancer. It uses a special dye and tracer to find the first lymph node that drains from the tumor.
Valencia, ValenciaAges 18 years+ - NCT05108090Recruiting
Sentinel node biopsy for head and neck skin cancer
This study checks whether a “sentinel lymph node biopsy” can help find if skin cancer in the head or neck has spread to nearby lymph nodes. It uses special dye/medicine and imaging, then removes the cancer and the sentinel node soon after scanning.
Indianapolis, IndianaAges 18 years+ - NCT05774483Recruiting
Check nodes in early mouth cancer using a biopsy or planned neck surgery
This trial studies two ways to check whether early oral cavity cancer has spread to nearby neck lymph nodes. It compares sentinel node biopsy versus limited elective neck dissection to see which approach is more useful for people with node-negative tongue or inner-cheek cancers.
Mumbai, MaharashtraAges 18–80 - NCT06788548Recruiting
Fluorescence-Guided Surgery for Early Stomach Cancer
This trial tests a new technique that uses a special dye to highlight the first lymph nodes where stomach cancer might spread, allowing surgeons to remove only the necessary nodes during surgery. The goal is to reduce side effects while still effectively treating the cancer.
Beijing, Beijing MunicipalityAges 18–80 - NCT06704945RecruitingPhase 3
Skipping armpit surgery after good chemo response
This trial tests whether it's safe to skip armpit surgery in people whose breast cancer has responded well to chemotherapy and whose lymph nodes appear cancer-free on ultrasound. It aims to reduce side effects like arm swelling while still controlling the cancer.
SeoulAges 19 years+ - NCT06652672Recruiting
Sentinel Node and Organ-Sparing Surgery for Early Colon Cancer
This trial tests a less invasive surgery approach for early-stage colon cancer. It uses a special dye to find and remove only the first lymph node (sentinel node) while removing just the part of the colon with the tumor, possibly avoiding a bigger surgery.
AmersfoortAges 18 years+ - NCT06133543Recruiting
Robotic sentinel node biopsy for testicular cancer
This trial uses a robot and a special dye (ICG) to find and remove the first lymph node that might contain cancer cells in men with testicular cancer. It aims to reduce unnecessary lymph node removal while still detecting spread.
DüsseldorfAges 18–99 - NCT06085274Recruiting
SHINE: Using a special dye to find lymph nodes after breast cancer chemo
This study tests whether a special dye called indocyanine green (ICG) can help find sentinel lymph nodes during breast cancer surgery after chemotherapy. It may offer a safer and more effective way to check if cancer has spread.
Toronto, OntarioAges 18–80 - NCT05333523RecruitingPhase 3
Personalized neck radiation using a lymph node sentinel biopsy
This Phase 3 trial tests whether guiding neck radiation by checking the “sentinel” lymph node can target treatment more precisely in certain larynx, hypopharynx, or oropharynx cancers. It aims to improve control while potentially reducing unnecessary radiation to areas that don’t need it.
AmsterdamAges 18 years+ - NCT05646316RecruitingPhase 3
Sentinel lymph node mapping to reduce leg swelling after surgery
This study tests whether a special way of finding lymph nodes during hysterectomy can lower the risk of long-term leg swelling or related dysfunction in people with stage I endometrial cancer. It compares standard lymph node assessment with sentinel lymph node mapping and looks at how this affects day-to-day leg functioning.
Washington D.C., District of ColumbiaAges 18 years+ - NCT04889924Recruiting
Lymph node surgery vs radiation after chemo for breast cancer
This trial compares two ways to treat the underarm lymph nodes in people whose sentinel lymph node still shows limited cancer after chemotherapy and hormone treatment. It may help find which approach controls cancer better with fewer side effects.
Sydney, New South WalesAges 18 years+ - NCT04333537RecruitingPhase 2/Phase 3
Sentinel node biopsy versus standard neck surgery for early mouth cancer
This trial compares two ways of checking whether early oral cavity squamous cell cancer has spread to neck lymph nodes. It tests whether sentinel lymph node biopsy can find spread as well as standard neck dissection, while potentially reducing more extensive surgery for some people.
Birmingham, AlabamaAges 18 years+ - NCT04073706RecruitingPhase 3
Sentinel node biopsy for early womb cancer
This trial tests whether a less invasive way to check if cancer has spread to lymph nodes (sentinel node biopsy) works as well as the standard method. It is for people with early-stage endometrial cancer having surgery.
Houston, TexasAges 18 years+ - NCT04109079Recruiting
Best surgery plan for breast cancer lymph nodes after chemotherapy
This study looks at the safest and most useful way to remove and check breast-cancer lymph nodes in the armpit after you finish chemotherapy given before surgery. It may help you avoid unnecessary surgery while still getting accurate information about how well the treatment worked.
DublinAges 18 years+ - NCT05839912Recruiting
Surgery study for melanoma in one lymph node basin
This trial tests whether removing a clinically involved lymph node basin (via a specific lymph node excision surgery) after certain melanoma findings is helpful. It mainly aims to see effects on outcomes and on arm/leg swelling (lymphedema) after surgery.
Atlanta, GeorgiaAges 18 years+ - NCT07049276Recruiting
Lymph node surgery for melanoma with immunotherapy
This trial tests if a specific type of lymph node surgery, combined with a short course of immunotherapy (medicines that help your immune system fight cancer), works better for melanoma that has spread to nearby lymph nodes. It's for people whose melanoma can be removed and who are healthy enough for treatment.
Los Angeles, CaliforniaAges 18 years+ - NCT06870903Recruiting
Comparing two lymph node removal methods in vaginal surgery for early endometrial cancer
This trial compares two ways of removing lymph nodes during a vaginal minimally invasive surgery for early-stage endometrial cancer. It aims to find which method is safer and more effective.
Diyarbakır, BaglarAges 18–85
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Common questions
- Are there clinical trials for sentinel lymph node?
- Yes. Clin2 currently lists 95 recruiting sentinel lymph node studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sentinel lymph node trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sentinel lymph node trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.