Clinical trials
Sepsis, Severe clinical trials
Below are recruiting sepsis, severe clinical trials, each written for real people, not researchers. We’re tracking 32 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06809868Recruiting
Study of genetic elements in sepsis and aging
This trial looks at how certain genetic elements may affect the immune system in older adults with sepsis. It aims to understand why older patients may respond differently to severe infections.
San Francisco, CaliforniaAges 18 years+ - NCT05304728Enrolling by invitation
Hospital sepsis decision support program enrollment study
This study tests a computer system meant to help doctors recognize and manage sepsis (a serious body-wide response to infection) when people come to the emergency department or are admitted to the hospital. If you’re evaluated in a hospital setting for possible sepsis, you may be included to help improve care decisions.
Irvine, CaliforniaAges 18–89 - NCT07706413Recruiting
Plasma exchange for children with severe sepsis
This trial tests whether removing harmful substances from the blood (plasma exchange) can help children with severe infections that cause organ failure or very low blood pressure. If your child is in the hospital with severe sepsis or septic shock and is between 1 month and 18 years old, this treatment might be an option.
Shibīn al Kawm, Menoufia GovernorateAges 1 month–18 years - NCT05491941Recruiting
Testing ways to improve care for sepsis patients
This trial looks at how to best put proven sepsis care steps into practice in the emergency department. It may help you or other patients receive faster, more consistent treatment for sepsis.
Providence, Rhode IslandAges 18 years+ - NCT04203979Recruiting
Sepsis care tailored to patients
This study looks at how to better recognize and manage sepsis (a serious body-wide reaction to infection) and tailor care to the individual. You may be eligible if you are newly admitted to the emergency department and your care is handled by a rapid response team for sepsis.
OsloAges 18 years+ - NCT04955210Recruiting
Study of data sharing in children with severe infections
This trial builds a shared medical data system to better understand severe pneumonia and sepsis in children. Your participation helps clinicians and researchers learn from many cases to improve future care.
Shanghai, Shanghai MunicipalityAges 4 weeks–18 years - NCT03244293Recruiting
Using a brain monitoring number to grade sepsis severity
This trial tests whether a bedside monitoring number called BIS can help sort sepsis into severity levels. If you have sepsis in the ICU, it may help clinicians track how serious it is and guide care.
Dalian, DalianAges Any age - NCT03044223Recruiting
Profiles of immune cells in severe Pseudomonas sepsis
This study looks at patterns of immune cells in people who are critically ill with sepsis caused by Pseudomonas aeruginosa bacteria. It may help doctors better understand how the immune system responds and improve care for this serious infection.
UlmAges 18–90 - NCT05836272RecruitingPhase 4
Early norepinephrine for low blood pressure in sepsis
This trial tests whether starting norepinephrine early can improve outcomes for adults with sepsis who have low blood pressure. It may help stabilize circulation sooner and reduce complications from severe infection.
TunisAges 18 years+ - NCT05975671Recruiting
Survey in pediatric ICU to reduce upfront vancomycin use
This study is a survey and quality-improvement effort in participating children’s intensive care units. It aims to understand and change how doctors decide to start vancomycin (an antibiotic) when sepsis is suspected, to improve care and avoid unnecessary use.
Atlanta, GeorgiaAges Any age - NCT06178822Recruiting
New blood tests to diagnose sepsis in the ER
This study aims to find new ways to quickly diagnose sepsis (a severe response to infection) in patients arriving at the emergency room. If successful, these new tests could help doctors start treatment faster.
Almere Stad, FlevolandAges 18 years+ - NCT07060560Recruiting
Presepsin blood test for severe burn sepsis diagnosis
This study tests a blood test called presepsin to see how well it detects sepsis in people with severe burns. If you have burns covering at least 20% of your body and your doctor suspects sepsis, this trial may help improve early diagnosis and treatment.
Seoul, SeoulAges 18 years+ - NCT02936232Recruiting
Registry for severe sepsis and septic shock
This registry collects medical information from adults who have suspected or proven serious infection causing body organ problems. It helps researchers better understand what happens in severe sepsis and septic shock and may guide future care.
Seongnam-si, Gyeonggi-doAges 18 years+ - NCT05875740Recruiting
Memory T cells and sepsis severity study
This study looks at a type of immune cell called 'memory CD8+ T cells' in patients with sepsis, a life-threatening response to infection. The goal is to see if these cells are linked to how severe the sepsis is and the risk of dying. This may help doctors better predict outcomes for people with sepsis.
Wuhan, HubeiAges 18–60 - NCT04850456Recruiting
Gamma globulin treatment for critically ill children with inflammation surge
This trial studies whether giving “human gamma globulin” can improve outcomes in very sick children in the ICU who have a severe infection causing an extreme inflammation reaction (“inflammatory storm”). If you’re in the hospital ICU with this complication, the study may offer a targeted treatment strategy and careful monitoring.
Shanghai, Shanghai MunicipalityAges 4 weeks–18 years - NCT05442710RecruitingPhase 2
Immune cell treatment for recovery from severe septic shock
This trial tests an immune-cell treatment given outside the body to help people recover from septic shock, a life-threatening reaction to infection. It aims to improve survival and organ recovery in patients who are still very ill despite standard care.
Freiburg im Breisgau, Baden-WurttembergAges 18 years+ - NCT06143137Recruiting
Long-term recovery after septic shock treatment
This study checks on people who had septic shock and were in the ReActIF-ICE trial. It looks at how their immune system recovered over time after an experimental therapy.
MagdeburgAges 18–80 - NCT06655389Recruiting
Link between PLA levels and sepsis heart failure severity
This study looks at how levels of a substance called PLA relate to how severe sepsis-related heart failure is. It may help doctors understand your condition better and guide treatment.
Beijing, Beijing MunicipalityAges 50–90 - NCT04961580Recruiting
Study of ceftazidime dosing in sick children
This trial measures how ceftazidime (an antibiotic) moves through the body and how it works in children with severe infections in the pediatric intensive care unit. It may help doctors choose safer, more effective dosing for kids.
Shanghai, Shanghai MunicipalityAges 3 months–18 years - NCT06372444Recruiting
Kidney injury in severe infections study
This study looks at how severe infections like sepsis can hurt the kidneys. By using special scans (PET-CT), researchers hope to better understand why this happens, which could lead to better treatments.
UppsalaAges 30 years+ - NCT06545838Recruiting
Testing renin levels to predict septic shock severity
This trial checks if a blood test measuring renin (a kidney hormone) can help predict how severe septic shock will be and how well patients recover. It looks for early clues in ICU patients with sepsis.
MoscowAges 18 years+ - NCT04178915Enrolling by invitation
Blood marker study to predict severe bacterial lung infection
This study looks at specific immune cells and how fats are transported in the blood to predict which people will have a severe bacterial infection (like pneumonia or sepsis). Your results may help doctors identify higher-risk patients earlier.
MinskAges 18–60 - NCT06516601Recruiting
Severe community-acquired pneumonia observational study
This study looks at patients with severe pneumonia caught outside the hospital. Researchers will review medical records to learn more about how this serious infection progresses.
Trieste, TSAges 18 years+ - NCT05688774Recruiting
Study of worsening community pneumonia in people with weaker immunity
This study follows how community-acquired pneumonia progresses in hospitalized patients who already have serious health problems or weakened immune systems. The goal is to better understand risk and changes over time, which may help guide future care for people like you.
BerlinAges 18–99
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Common questions
- Are there clinical trials for sepsis, severe?
- Yes. Clin2 currently lists 32 recruiting sepsis, severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sepsis, severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sepsis, severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.