Clinical trials
Severe Aortic Stenosis clinical trials
Below are recruiting severe aortic stenosis clinical trials, each written for real people, not researchers. We’re tracking 141 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04414878Recruiting
Transcatheter aortic valve replacement for older, high-risk patients
This trial tests a new heart valve replacement done through a catheter (not open-heart surgery) in older adults with severe aortic valve narrowing. It’s mainly for people who are high-risk or not good candidates for standard surgery, to see if the new valve improves outcomes.
Beijing, Beijing MunicipalityAges 70 years+ - NCT06874465Recruiting
Aortic valve replacement study for severe stenosis
This study tracks patients getting a new heart valve (transcatheter aortic valve implantation) for severe aortic stenosis. It aims to understand long-term outcomes and safety in a real-world registry.
AstanaAges 18 years+ - NCT06420830Recruiting
Study of a new heart valve in TAVR
This study follows patients with severe aortic stenosis who get a new heart valve (the SAPIEN 3 Ultra RESILIA) through a less invasive procedure (TAVR). Researchers want to see how well this valve works over time using special heart ultrasound tests.
Québec, QuebecAges 18–80 - NCT06000943Recruiting
Bleeding and clot risk after heart valve procedure
This study looks at patients who had a TAVR procedure (a new valve put in the heart) to understand their risk of bleeding or clots over the next year. It tracks changes in blood thinner medications at 1 month, 90 days, and 1 year to help doctors personalize care.
AalstAges 18 years+ - NCT05779787Recruiting
Registry after aortic valve procedure to guide future care
This registry is for people with severe, symptomatic aortic valve narrowing who are planning a TAVI procedure (a less invasive valve replacement). It aims to better track and improve how patients do after the valve is replaced, based on how the procedure is planned and performed.
Milan, LombardyAges 18 years+ - NCT07258706Enrolling by invitation
Study on TAVI results based on patient differences
This trial is for people with severe aortic stenosis who are already scheduled for TAVI (a procedure to replace a narrowed heart valve). It looks at how individual differences affect the procedure's outcomes.
VicenzaAges 18 years+ - NCT05886517Recruiting
Transcatheter aortic valve in patients too high-risk for surgery
This trial looks at placing a new aortic valve through the groin (transfemoral) without needing on-site heart surgery for people who are considered very high risk for standard open-heart valve surgery. It aims to measure early outcomes to see how safe and effective this approach is for frail or complex patients.
Acquaviva delle Fonti, BariAges 75–120 - NCT07042529Recruiting
Optimizing valve placement during TAVI
This trial is testing a better way to position a new heart valve during a TAVI procedure. The goal is to help the valve work as well as possible for people with severe aortic stenosis.
AalstAges 18 years+ - NCT04414865Recruiting
Check a new heart valve treatment for older, high-risk patients
This study follows how the VitaFlow heart valve works in people age 70+ who have severe, narrowed aortic valves and cannot safely get open-heart valve surgery. It’s meant to see whether the device improves outcomes and is safe over time.
Shanghai, Shanghai MunicipalityAges 70 years+ - NCT06689839Recruiting
Testing a new filter to prevent stroke during heart valve replacement
This trial tests a new filter device designed to catch debris that might travel to the brain during a minimally invasive aortic valve replacement (TAVR). The goal is to see if it can help reduce the risk of stroke.
Naples, FloridaAges 50 years+ - NCT06818435Recruiting
Registry study of the Myval heart valve for severe aortic stenosis
This study is tracking how well the Myval valve works in people with severe aortic stenosis who get it through a minimally invasive procedure called TAVI. It helps doctors learn more about the valve's safety and performance in real-world use.
CarnaxideAges 18 years+ - NCT06507579Recruiting
Aortic stenosis valve replacement study with Hydra device
This trial tests a new heart valve called Hydra for people with severe aortic stenosis who need a valve replacement through a leg artery. It aims to see how well the valve works in real-world patients.
Sheffield, YorkshireAges 18–99 - NCT06342635Recruiting
Study of Hydra Heart Valve in Copenhagen
This study is testing a new heart valve system called Hydra, used during a less invasive procedure called TAVI to replace a narrowed heart valve. It may help people with severe aortic stenosis who are already candidates for TAVI.
CopenhagenAges 18–99 - NCT06101888Recruiting
New Heart Valve for Severe Aortic Leak
This study is testing a new, less invasive heart valve system (TaurusTrio) for people with severe aortic regurgitation (a leaky aortic valve) who cannot have open-heart surgery. It aims to see if the valve is safe and works well to improve symptoms.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06753227Enrolling by invitation
Comparing ways to measure valve pressure after TAVI
This trial looks at how well a new method (using echo) compares to the standard invasive method for measuring pressure across the new valve after TAVI. It may help doctors monitor your valve function with less risk.
Munich, BavariaAges 18 years+ - NCT05172973Recruiting
New valve procedure for failing aortic bioprosthetic valves
This trial studies whether a new transcatheter aortic valve (SAPIEN X4) is safe and works well in people whose previously implanted aortic valve is now failing. It may help reduce valve symptoms in higher-surgery-risk patients who are not good candidates for open-heart valve replacement.
Newport Beach, CaliforniaAges Any age - NCT06768008Recruiting
Integrated care model for newborns with critical heart disease
This trial tests a coordinated treatment plan for newborns with critical congenital heart disease, starting before birth and continuing after delivery. It aims to improve outcomes for babies who need two-ventricle repair surgery.
BeijingAges 1 day–4 weeks - NCT07752732Recruiting
Heart scans for amyloidosis in people with severe aortic valve stenosis
This study looks at how often cardiac amyloidosis occurs in people with severe aortic valve stenosis. It uses different heart scans to find out more. If you have both conditions, this research may help doctors understand your situation better.
TübingenAges 18 years+ - NCT06379386Recruiting
Long-term results of TAVR for severe aortic valve regurgitation
This trial follows people who have severe aortic valve regurgitation and get a TAVR. It looks at how well the valve works over time and how patients do in the long run.
Xi'an, ShannxiAges 18 years+ - NCT06535659Recruiting
VitaFlow Liberty Valve Study for Severe Aortic Stenosis
This trial tests a new valve replacement device (VitaFlow Liberty) that is inserted through a tube in an artery, avoiding open-heart surgery. It is for people with severe aortic stenosis who are at high risk for traditional surgery.
GalwayAges 18 years+ - NCT07045233Enrolling by invitation
Using a brain protection device during TAVR to prevent stroke
This study tests if a special device placed during transcatheter aortic valve replacement (TAVR) can help prevent stroke. It is for adults with severe aortic stenosis who are already scheduled for TAVR.
BeijingAges 18 years+ - NCT06780241Recruiting
Sex differences in valvular heart disease
This study uses special MRI scans to look at how valvular heart disease (like leaky or narrowed aortic valves) affects men and women differently. It aims to find unique biological patterns that could lead to better treatments.
Cleveland, OhioAges 18–90 - NCT07201363Recruiting
Inflammation and scarring markers after TAVI
This study looks at markers of inflammation and scarring in people who develop heart rhythm problems after having a TAVI procedure (a minimally invasive valve replacement). It may help doctors understand and predict these complications.
Rijeka, CroatiaAges 18 years+ - NCT07455292Recruiting
Heart valve study using advanced MRI
This study uses a special type of MRI, called 4D flow MRI, to better understand how severe aortic stenosis (a narrowed heart valve) affects heart function. It may help doctors learn more about different types of this condition and improve future treatment.
San Donato MilaneseAges 18 years+
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Common questions
- Are there clinical trials for severe aortic stenosis?
- Yes. Clin2 currently lists 141 recruiting severe aortic stenosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe aortic stenosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe aortic stenosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.