Clinical trials
Aortic Stenosis With Bicuspid Valve clinical trials
Below are recruiting aortic stenosis with bicuspid valve clinical trials, each written for real people, not researchers. We’re tracking 33 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07413965Recruiting
Transcatheter vs surgical valve replacement for severe bicuspid aortic stenosis
This trial compares two ways to replace a narrowed heart valve in people with a bicuspid aortic valve. If you're 50 or older and need a new valve, this study can help figure out which approach works best.
Los Angeles, CaliforniaAges 50 years+ - NCT07453407Recruiting
Tavi valve vs surgery for severe aortic regurgitation
This trial compares a new catheter-based valve (J-Valve) with open-heart surgery for people with severe aortic regurgitation, a condition where the aortic valve doesn't close tightly. It aims to see which treatment is safer and more effective.
Hefei, AnhuiAges 65 years+ - NCT05511792Recruiting
Smaller valve size approach versus standard valve size in TAVR
This trial compares a “smaller valve sizing” approach versus the usual sizing method during TAVR (a catheter-based valve replacement) for people with bicuspid aortic stenosis. The study aims to see which method improves safety and outcomes for the right valve fit.
Fuzhou, FujianAges 60 years+ - NCT06991517Recruiting
TAVR sizing study for bicuspid aortic valve patients
This study tests a special sizing method (ABC algorithm) to help doctors select the right valve for people with a bicuspid aortic valve. It aims to improve outcomes for those getting a Sapien 3 valve through a catheter (TAVR).
St Leonards, New South WalesAges Any age - NCT07194265Recruiting
A study of the DurAVR heart valve for aortic stenosis
This trial tests a new heart valve called DurAVR for people with severe aortic stenosis (a narrowed aortic valve) who need a valve replacement. It compares the new valve to standard valves to see if it is safe and works well.
Copenhagen, Capital Region of DenmarkAges 18 years+ - NCT03836521Recruiting
Registry for valve replacement in bicuspid aortic stenosis patients
This registry collects information about adults with severe narrowing of the aortic valve caused by a bicuspid (two-leaflet) valve shape, especially if symptoms are present. It may help doctors better understand who benefits from a catheter-based valve replacement (TAVR).
Los Angeles, CaliforniaAges 19–129 - NCT04076150Recruiting
Testing a new valve placed through a blood vessel
This study checks whether an “investigational” transcatheter aortic valve is safe and works well for people with severe, calcified aortic stenosis (a stiff, narrowed heart valve). It may help improve valve function and symptoms, but you must meet specific heart, scan, and health-status requirements.
KrakowAges 70 years+ - NCT04722796Recruiting
TAVR for bicuspid aortic valve with a specific device
This study tests a “solution” approach using a self-expanding valve during TAVR (a less invasive way to replace a narrowed aortic valve). It aims to improve how well the valve fits and works in people with a specific heart valve shape (bicuspid aortic stenosis).
Bengbu, AnhuiAges 60 years+ - NCT04861805Recruiting
Transcatheter aortic valve replacement study for high-risk seniors
This study tests a self-expanding artificial aortic valve placed through a blood vessel (no open-heart surgery) in older adults with severe aortic valve narrowing. It may help improve symptoms and heart function by treating the blocked valve.
Bahía BlancaAges 65 years+ - NCT04889872Recruiting
Watchful waiting or TAVR for moderate aortic valve narrowing
This study compares regular monitoring (“clinical surveillance”) versus replacing the aortic valve using a minimally invasive procedure called TAVR for people with moderate aortic stenosis. It aims to see which approach better reduces symptoms or heart damage over time.
Huntsville, AlabamaAges 65 years+ - NCT05739253Recruiting
Study how the aorta changes after a valve procedure
This trial looks at how the ascending aorta (the main artery near the heart) changes over time after transcatheter aortic valve replacement. It may help doctors predict who is at risk of aorta enlargement after this less-invasive valve procedure.
Beijing, Beijing MunicipalityAges Any age - NCT05886517Recruiting
Transcatheter aortic valve in patients too high-risk for surgery
This trial looks at placing a new aortic valve through the groin (transfemoral) without needing on-site heart surgery for people who are considered very high risk for standard open-heart valve surgery. It aims to measure early outcomes to see how safe and effective this approach is for frail or complex patients.
Acquaviva delle Fonti, BariAges 75–120 - NCT06455787Recruiting
J-Valve study for leaky aortic valve patients
This study tests a new, less invasive device called J-Valve for people with severe aortic regurgitation (a leaky aortic valve). It is placed through a tube in the leg artery, avoiding open-heart surgery, and may help those who are at high risk for surgery.
Scottsdale, ArizonaAges 18 years+ - NCT06595407Recruiting
Loss of Y Chromosome in Aortic Stenosis Study
This study looks at how losing the Y chromosome in blood cells may be linked to aortic stenosis, a narrowing of the heart's aortic valve. It aims to understand why this condition may be more severe in men.
Charlottesville, VirginiaAges 40 years+ - NCT06596460Recruiting
Imaging study after TAVI valve replacement
This study collects extra imaging data from 40 people who are already scheduled for a routine TAVI procedure to replace a narrowed aortic heart valve. The goal is to better understand the valve's structure and function using scans.
London, EnglandAges 18 years+ - NCT06608823Recruiting
Comparing surgery vs. the Trilogy valve for aortic regurgitation
This trial compares a new less-invasive valve replacement (Trilogy TAVR) with standard open-heart surgery for people with significant aortic regurgitation. It aims to see which treatment works better for patients who are eligible for both procedures.
Burlingame, CaliforniaAges Any age - NCT07001800RecruitingPhase 2/Phase 3
Slowing aortic valve disease with ataciguat
This trial tests a new pill, ataciguat, to slow down the progression of moderate calcific aortic valve stenosis (a condition where your aortic valve stiffens). If you have moderate valve narrowing and meet the other criteria, participation could help find a way to delay needing surgery.
Birmingham, AlabamaAges 50 years+ - NCT06817148Recruiting
TAVR vs surgery for bicuspid aortic valve disease
This study compares two treatments for severe aortic stenosis in people with a bicuspid aortic valve: transcatheter aortic valve replacement (TAVR, a less invasive procedure) and surgical aortic valve replacement (SAVR, open-heart surgery). The goal is to see which approach works better for this specific condition.
Los Angeles, CaliforniaAges 50 years+ - NCT06830499Recruiting
Sapien 3 valve for younger Chinese patients with severe aortic stenosis
This trial tests a newer artificial heart valve (Sapien 3) placed through a small tube in the leg, for younger people (50–70) with severe aortic stenosis. It aims to see if this less invasive option works well in this age group.
Xi'an, ShaanxiAges 50–70 - NCT06869954Recruiting
Bicuspid aortic valve repair: comparing two surgical techniques
This trial tests two different ways to repair a leaky bicuspid aortic valve (a valve with two flaps instead of three). The goal is to see which repair method works better. If you need surgery for a severely leaking valve and your valve is the right shape, you may be able to join.
Augsburg, BavariaAges 18 years+ - NCT07097740Recruiting
Study of a new polymer heart valve for mitral or aortic replacement
This study tests a new type of prosthetic heart valve made from a special polymer material. It is for adults who need surgical replacement of either the mitral or aortic valve.
Shanghai, Shanghai MunicipalityAges 50 years+ - NCT05851209Recruiting
Study biomarkers in people with moderate aortic valve narrowing
This study looks at blood and/or body signals (called biomarkers) to understand why aortic valve narrowing may worsen and what outcomes people have. You may be able to help researchers by undergoing regular heart care plus additional testing like MRI or CT if you qualify.
BonnAges 18 years+ - NCT07620925Recruiting
Aortic Valve Calcium Score Study Using Heart Ultrasound
This study develops and tests a new way to diagnose severe aortic stenosis (narrowing of the aortic valve) by measuring calcium buildup on the valve using heart ultrasound. If you're already getting both an ultrasound and a CT scan of your heart, this study compares how well the ultrasound method can identify severe stenosis.
BolognaAges 18 years+ - NCT06597188Enrolling by invitation
TAVR vs. Surgery for severe bicuspid aortic valve stenosis
This trial compares a less invasive valve replacement (TAVR) with traditional open-heart surgery for people with a specific type of severe aortic valve narrowing (bicuspid valve). It aims to see which approach works better for those at intermediate or low surgical risk.
Chengdu, SichuanAges 18–75
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Common questions
- Are there clinical trials for aortic stenosis with bicuspid valve?
- Yes. Clin2 currently lists 33 recruiting aortic stenosis with bicuspid valve studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic stenosis with bicuspid valve trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic stenosis with bicuspid valve trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.