Clinical trials
Severe Aortic Stenosis clinical trials
Below are recruiting severe aortic stenosis clinical trials, each written for real people, not researchers. We’re tracking 146 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07045233Enrolling by invitation
Using a brain protection device during TAVR to prevent stroke
This study tests if a special device placed during transcatheter aortic valve replacement (TAVR) can help prevent stroke. It is for adults with severe aortic stenosis who are already scheduled for TAVR.
BeijingAges 18 years+ - NCT05788770Recruiting
CT scan and computer planning before TAVR valve replacement
This study uses a CT scan plus a personalized computer model to plan a less invasive valve replacement (TAVR). It may help doctors better prepare for the procedure using simulation before your valve is placed.
ViennaAges 18 years+ - NCT07201363Recruiting
Inflammation and scarring markers after TAVI
This study looks at markers of inflammation and scarring in people who develop heart rhythm problems after having a TAVI procedure (a minimally invasive valve replacement). It may help doctors understand and predict these complications.
Rijeka, CroatiaAges 18 years+ - NCT07455292Recruiting
Heart valve study using advanced MRI
This study uses a special type of MRI, called 4D flow MRI, to better understand how severe aortic stenosis (a narrowed heart valve) affects heart function. It may help doctors learn more about different types of this condition and improve future treatment.
San Donato MilaneseAges 18 years+ - NCT06055751Recruiting
Heart rhythm monitoring after aortic valve replacement
This trial studies people who had a heart valve procedure called TAVI and later had a heart rhythm problem. You will get a tiny heart monitor placed under your skin to track your heart rhythm over time and help doctors understand how common these problems are.
Kansas City, MissouriAges 18 years+ - NCT05603026Recruiting
MRI study for people getting a valve replacement
This study uses MRI (a type of scan) in people who are scheduled for a catheter-based aortic valve replacement through the groin. It aims to see how well MRI can work for these patients and potentially improve care planning around the procedure.
Cleveland, OhioAges 18–105 - NCT07107568Recruiting
Testing ways to check heart arteries before valve replacement
This trial compares different methods to evaluate coronary artery disease in patients planning to have a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. The goal is to find out if a less invasive approach is as safe and effective as the standard one.
InnsbruckAges 18 years+ - NCT05758662Recruiting
PET-CT and heart ultrasound study valve changes after TAVI
This study looks at whether certain valve blood clots (called “subclinical leaflet thrombosis”) and different valve types are linked to valve aging over time. It uses a special PET-CT scan and an echocardiogram to measure changes in the heart valve about five years after TAVI.
CopenhagenAges 18 years+ - NCT06603454Recruiting
Chest CT before aortic valve replacement surgery
This study looks at whether a CT scan of the chest before aortic valve replacement surgery (with or without bypass) can help doctors plan the procedure better. It is for people with severe aortic valve stenosis who are already scheduled for surgery.
Nieuwegein, UtrechtAges 18 years+ - NCT06991517Recruiting
TAVR sizing study for bicuspid aortic valve patients
This study tests a special sizing method (ABC algorithm) to help doctors select the right valve for people with a bicuspid aortic valve. It aims to improve outcomes for those getting a Sapien 3 valve through a catheter (TAVR).
St Leonards, New South WalesAges Any age - NCT07205068Recruiting
Shockwave treatment for TAVR access site
This trial tests if using Shockwave IVL to break up calcium in the groin artery before a TAVR procedure can improve outcomes. It may help patients with significant calcium buildup at the access site.
Knoxville, TennesseeAges 18 years+ - NCT06833762Recruiting
Predicting improvement after TAVI using exercise tests
This trial looks at whether a simple exercise test (called CPET) can help predict how much your heart function will improve after TAVI, a procedure to replace a narrowed heart valve. If you're scheduled for TAVI through your leg artery and are 18 or older, you might be able to join.
BarcelonaAges 18 years+ - NCT04552275RecruitingPhase 1
Biomarker study during valve replacement for older adults
This Phase 1 study looks at changes in the body’s “biomarkers” (measurable signs in blood/medical tests) in older people who are getting a specific type of valve replacement. Results may help doctors better monitor or understand outcomes after this valve procedure.
Boston, MassachusettsAges 65 years+ - NCT05866640RecruitingEarly Phase 1
Testing a filter to reduce debris during TAVR
This early feasibility study tests a device filter system used during a TAVR procedure to help protect the brain and other organs from debris that can break free. It looks mainly at whether the filter can be safely placed and delivered as planned.
TbilisiAges 22 years+ - NCT07035847Recruiting
Transaxillary TAVR guided by ultrasound only
This trial is testing a new way to replace your aortic valve using a small tube through your armpit, guided only by ultrasound (echocardiography) instead of X-rays. It may be an option if you have severe aortic stenosis and are a good fit for this less invasive approach.
Beijing, Beijing MunicipalityAges Any age - NCT07230964Recruiting
Heart valve study using a non-invasive skin test
This trial tests a special skin test (impedance cardiography) that may detect heart muscle changes in people with aortic stenosis. It could help doctors decide when valve replacement is needed.
Chicago, IllinoisAges 18 years+ - NCT06911463Enrolling by invitation
Pain relief for TAVI valve procedure
This study tests two numbing injections for people having a new aortic valve placed through a leg artery (TAVI). One injection is near the hip bone, the other in the groin area. The goal is to see which one provides better pain control while keeping you awake and comfortable.
CairoAges 20 years+ - NCT06049654Recruiting
Comparing Allegra and Sapien valves for valve-in-valve procedure
This trial tests two different replacement heart valves (Allegra and Sapien) to see which works better for people who need a new valve placed inside a previously implanted surgical valve. It aims to help patients with a failing biological aortic valve who are already scheduled for this procedure.
AlessandriaAges 18 years+ - NCT05862558Recruiting
Lithotripsy to open blocked, calcified artery for TAVR
This trial tests whether a treatment called intravascular lithotripsy (using sound waves from inside a blood vessel) can help widen severely calcified, narrowed iliac arteries so a TAVR procedure can be done through the groin. It may help some people who are considered “high risk” for access, based on CT scan findings.
Plano, TexasAges 18–90 - NCT03470246Recruiting
Wearable activity coaching after heart surgery
This study tests a personalized activity program and coaching after heart surgery, using wearable sensors to track movement. It may help you recover more safely and move in a goal-directed way during rehabilitation.
KuopioAges 30–90 - NCT05308888RecruitingPhase 2
PET scan study of heart inflammation after aortic valve replacement
This Phase 2 trial uses a PET scan to study how local inflammation inside the heart affects the heart’s electrical wiring after a minimally invasive aortic valve procedure. The results may help doctors better predict or prevent rhythm and conduction problems after treatment.
BrestAges 18 years+ - NCT05721170RecruitingPhase 4
Beta blockers after TAVI in high-risk adults with valve narrowing
This study tests whether stopping beta blockers after TAVI is safe and effective compared with continuing them. It may help clarify the best medication plan after valve replacement for people at higher surgical risk.
NicosiaAges 18 years+ - NCT06215378RecruitingPhase 3
Protamine Sulfate to Reverse Heparin After TAVI
This trial tests whether giving protamine sulfate after a TAVI procedure (aortic valve replacement through the leg) to reverse the blood thinner heparin is safe and effective. It may help reduce bleeding risk for patients.
Paris, Île-de-France RegionAges 18 years+ - NCT06437600Recruiting
Immediate balloon angioplasty for severe stroke with brain artery narrowing
This trial tests whether doing an angioplasty (a procedure to open a narrowed artery with a small balloon) as soon as possible after a severe stroke caused by a blockage in a brain artery can improve recovery. It is for people who arrive within 24 hours of their stroke and have a specific type of narrowing inside the skull.
Guangzhou, GuangdongAges 18 years+
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Common questions
- Are there clinical trials for severe aortic stenosis?
- Yes. Clin2 currently lists 146 recruiting severe aortic stenosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe aortic stenosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe aortic stenosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.