Clinical trials
Severe Aortic Stenosis clinical trials
Below are recruiting severe aortic stenosis clinical trials, each written for real people, not researchers. We’re tracking 146 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06917066Recruiting
Registry for severe aortic stenosis patients getting a specific TAVR valve
This study tracks patients with severe aortic stenosis who receive the Myval transcatheter heart valve during TAVR (a less-invasive valve replacement). It aims to understand how well the valve works over time.
Valladolid, ValladolidAges 18 years+ - NCT07343674Recruiting
Studying a new heart valve replacement system for aortic stenosis
This trial is testing a new heart valve system (Medtronic Evolut FX+) for people with severe aortic stenosis—a condition where the heart's main valve is narrowed. The study aims to see how well the valve works and improve your care journey.
Coimbra, Coimbra DistrictAges 18 years+ - NCT07709858Recruiting
Outcomes after TAVR for severe aortic valve disease
This is a registry study that tracks how people do after a TAVR procedure for a severely narrowed aortic heart valve. It helps doctors learn more about long-term outcomes and improve care for future patients.
SeoulAges 18 years+ - NCT06047561Recruiting
Scottish Aortic Stenosis Imaging Study
This study looks at how aortic stenosis (a narrowing of the heart valve) changes over time using imaging and blood tests. It may help doctors better understand and treat this condition.
EdinburghAges 50 years+ - NCT06749145Enrolling by invitation
Using deep learning to find aortic stenosis earlier
This study tests if a deep learning tool can help detect aortic stenosis, a heart valve condition, in older adults during routine primary care visits. If you are 70 or older and have not had a recent echocardiogram, you may be able to join.
New Haven, ConnecticutAges 70 years+ - NCT06924151Recruiting
Surgery for Aortic Valve in Low Risk Patients
This trial tests if surgery to replace your aortic valve is safe and effective for people with severe aortic stenosis who are at low risk for complications. It compares surgery to another procedure to see which works best.
Nagoya, Aichi-kenAges Any age - NCT06817148Recruiting
TAVR vs surgery for bicuspid aortic valve disease
This study compares two treatments for severe aortic stenosis in people with a bicuspid aortic valve: transcatheter aortic valve replacement (TAVR, a less invasive procedure) and surgical aortic valve replacement (SAVR, open-heart surgery). The goal is to see which approach works better for this specific condition.
Los Angeles, CaliforniaAges 50 years+ - NCT06381271Recruiting
TAVR for severe aortic valve regurgitation
This trial tests a procedure called TAVR to replace the aortic valve in people with severe aortic regurgitation (a leaky valve). It may help you if you have this condition and prefer a less invasive option than open-heart surgery.
Xi'an, ShannxiAges 18 years+ - NCT04861805Recruiting
Transcatheter aortic valve replacement study for high-risk seniors
This study tests a self-expanding artificial aortic valve placed through a blood vessel (no open-heart surgery) in older adults with severe aortic valve narrowing. It may help improve symptoms and heart function by treating the blocked valve.
Bahía BlancaAges 65 years+ - NCT06007222RecruitingPhase 4
No blood thinners after TAVI: a trial for heart valve patients
This trial is for people who have had a TAVI procedure to replace a narrowed heart valve, and it tests whether it is safe to skip blood thinners afterward. The goal is to find the best way to protect your health without unnecessary medication.
Shinjuku, TokyoAges 20 years+ - NCT06472934Recruiting
Beta-blockers & TAVR study
This study tests whether continuing a beta-blocker (a heart medication) improves outcomes for people having a planned TAVR (a minimally invasive heart-valve replacement). It may help doctors decide whether to keep or stop this medicine after the procedure.
GrazAges 18 years+ - NCT04634240Recruiting
Staged heart bypass plus TAVR versus TAVR alone
This study compares doing a staged coronary bypass (revascularization) along with a valve procedure (TAVR) versus doing TAVR and medical treatment alone. It aims to see which approach better helps people with both aortic valve narrowing and coronary artery disease.
Huntsville, AlabamaAges Any age - NCT03836521Recruiting
Registry for valve replacement in bicuspid aortic stenosis patients
This registry collects information about adults with severe narrowing of the aortic valve caused by a bicuspid (two-leaflet) valve shape, especially if symptoms are present. It may help doctors better understand who benefits from a catheter-based valve replacement (TAVR).
Los Angeles, CaliforniaAges 19–129 - NCT04454177Recruiting
Smartwatch help to discharge earlier after valve replacement
This study tests whether using a smartwatch can safely help people leave the hospital earlier after a transcatheter aortic valve replacement (TAVR). It checks comfort, safety, and follow-up at home.
Hangzhou, ZhejiangAges 18 years+ - NCT06009588Recruiting
Comparing Two Heart Valve Types for Aortic Stenosis with Aorta Dilation
This trial tests two types of artificial heart valves—one that expands on its own and one expanded with a balloon—in people with a widened upper aorta. The goal is to see which works better for your condition.
Beijing, Beijing MunicipalityAges 65 years+ - NCT07001800RecruitingPhase 2/Phase 3
Slowing aortic valve disease with ataciguat
This trial tests a new pill, ataciguat, to slow down the progression of moderate calcific aortic valve stenosis (a condition where your aortic valve stiffens). If you have moderate valve narrowing and meet the other criteria, participation could help find a way to delay needing surgery.
Birmingham, AlabamaAges 50 years+ - NCT06830499Recruiting
Sapien 3 valve for younger Chinese patients with severe aortic stenosis
This trial tests a newer artificial heart valve (Sapien 3) placed through a small tube in the leg, for younger people (50–70) with severe aortic stenosis. It aims to see if this less invasive option works well in this age group.
Xi'an, ShaanxiAges 50–70 - NCT05932615Enrolling by invitation
Testing a new transcatheter valve for aortic valve narrowing
This trial studies how safe and effective the NAVITOR valve is for treating narrowed aortic valves placed through a catheter (no open-heart surgery). It may be an option if you’re at intermediate-to-low surgical risk and meet heart ultrasound/CT measurements.
Birmingham, AlabamaAges 18 years+ - NCT06722066Recruiting
TAVR and heart valve calcium study
This study looks at how calcium buildup in the aortic valve affects long-term results after a TAVR procedure (a minimally invasive heart valve replacement). It may help doctors understand which patients do better over time.
SeoulAges 19 years+ - NCT04126018Recruiting
MRI scan comparison for certain leaking or narrowed heart valves
This trial studies how well different MRI images can assess heart valve problems—like leaking (regurgitation) or narrowing (stenosis). It may help doctors get clearer information, especially in people who may not respond well to cardiac resynchronization therapy (CRT).
Cleveland, OhioAges 18–90 - NCT07604402Recruiting
Aortic Valve Replacement Without On-Site Surgery
This study tests a catheter-based procedure to replace a narrowed aortic valve without traditional open-heart surgery. It's designed for patients who are at higher risk for surgery due to age, health conditions, or anatomy.
AndriaAges Any age - NCT05864456Recruiting
Study testing a new valve delivered through a blood vessel
This trial studies Prizvalve Pro™, a new transcatheter (catheter-based) aortic valve replacement, for people with severe aortic valve narrowing who are too high-risk for standard surgery. It may help your heart work better and improve symptoms by replacing the failing valve without open-heart surgery.
ShanghaiAges 65 years+ - NCT07370688RecruitingPhase 4
Iron infusion after TAVI for older adults
This trial tests whether giving iron infusions after a TAVI procedure can help patients with iron deficiency feel better and improve their quality of life. It is for older adults who have low iron levels and have already had a successful valve replacement.
Rotterdam, South HollandAges 65 years+ - NCT05235555Recruiting
TAVI registry for people with severe aortic valve disease
This registry follows people with severe aortic valve narrowing (and sometimes a worn-out valve) who are considered good candidates for TAVI, a valve-replacement procedure. It helps doctors better understand outcomes and care over time.
NaplesAges 55–100
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Common questions
- Are there clinical trials for severe aortic stenosis?
- Yes. Clin2 currently lists 146 recruiting severe aortic stenosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe aortic stenosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe aortic stenosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.