Clinical trials
Severe Mental Disorder clinical trials
Below are recruiting severe mental disorder clinical trials, each written for real people, not researchers. We’re tracking 170 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07490717Enrolling by invitation
Treating PTSD and opioid use in jails
This study tests new ways to screen and treat people in jail who have both post-traumatic stress disorder (PTSD) and opioid use disorder. It aims to help participants with therapy while incarcerated and after release.
Little Rock, ArkansasAges 18 years+ - NCT04447742Recruiting
Study of how healthy babies’ gut microbes develop from birth
This study follows pregnant people from about 20 weeks until delivery, to understand how gut microbes (tiny organisms in the intestines) develop in healthy babies. It may help researchers learn how early-life gut development affects health later on.
BernAges 18–45 - NCT06865937Recruiting
A mobile app to help with social recovery in serious mental illness
This study tests a mobile app that provides support for social recovery in people with serious mental illness. It may help you feel less isolated and more connected.
San Diego, CaliforniaAges 18–65 - NCT06800807Recruiting
Beliefs about thinking in teens with eating disorders
This study looks at how teens with eating disorders think about their own thoughts (called metacognition). It compares their responses to a group of teens without eating disorders to better understand the role of certain beliefs in these conditions.
Oggebbio, VerbaniaAges 12–17 - NCT06045897Recruiting
EEG brain test for young people at risk of psychosis
This study uses a short EEG recording to look at brain activity patterns in young people with early signs of mental health conditions, including those at risk for psychosis, first episode psychosis, depression, or autism. It aims to find brain markers that could help identify people who might benefit from early treatment.
ParisAges 15–30 - NCT02431845Recruiting
Study of OCD genes, proteins, and gut microbes
This study looks at genes, blood/brain proteins, and gut microbes in people with obsessive-compulsive disorder (OCD). It may help researchers understand what drives OCD and how treatments could be better tailored in the future.
SeoulAges 19–70 - NCT05537376Recruiting
Peer-led suicide prevention support for veterans with serious mental illness
This study tests a suicide-prevention program delivered by trained peer specialists (other people with similar lived experience) to help veterans who are currently having suicidal thoughts. It aims to add ongoing support and improve safety and recovery for veterans with serious mental health conditions.
San Diego, CaliforniaAges 18 years+ - NCT07679204Recruiting
Personality and life satisfaction in bipolar and depression
This study looks at how personality traits and life satisfaction affect people with bipolar II disorder or major depression. You will fill out questionnaires about your feelings and daily life.
ElâzığAges 18 years+ - NCT05943132Recruiting
Support for children in South Africa’s mental health program
This study tests a mental health support program for children who have a legal guardian and live in a specific community area. It aims to improve mental well-being for children ages 7–11 who are considered “OVC.”
Bloemfontein, Free StateAges 7–11 - NCT06112067Recruiting
Brain implant for severe mental health conditions
This trial tests a brain implant called deep brain stimulation (DBS) for people with severe mental health conditions that have not improved with usual treatments. The goal is to see if it can reduce symptoms and improve quality of life.
ShanghaiAges 18–65 - NCT05491538Recruiting
Work skills training for Veterans living with serious mental illness
This study tests whether a social-skills training program designed for work goals is doable and helpful for Veterans with serious mental illness. It focuses on improving work-related coping and interactions while you receive supported services through the VA.
Minneapolis, MinnesotaAges 18 years+ - NCT06005103Recruiting
Testing a headband that sends brain pulses for depression
This study tests a new headband that sends gentle electrical pulses to the brain (T-PEMF) to lift depression. You might join if you have moderate to severe depression and don't have certain other conditions or implants.
Frederiksberg, Capital RegionAges 18–65 - NCT06781801Recruiting
Heart and metabolic health for severe mental illness
This trial tests a long-term program to improve heart and metabolic health in adults with schizophrenia or related disorders. It may help reduce health risks often linked with severe mental illness.
GothenburgAges 18 years+ - NCT04882839RecruitingPhase 2
Therapy with psilocybin for severe OCD symptoms
This Phase 2 study tests whether psilocybin-assisted psychotherapy can reduce symptoms in adults with severe, treatment-resistant OCD. It also focuses on safety and whether this approach is practical to run.
BeershebaAges 18–65 - NCT03601026Recruiting
Genetic counseling for youth using cannabis safely
This study offers genetic counseling to help reduce mental health problems that can happen for some young people who use cannabis. You join if you are already part of the FORBOW study and fit their age and mental-health criteria.
Halifax, Nova ScotiaAges 12–21 - NCT07571226Recruiting
Urban Stress and Mental Health Monitoring Study
This study explores how city living and daily stress affect depression, anxiety, and alcohol use disorders by having you wear a monitoring wristband and use a smartphone app to track your physical responses. Researchers hope to better understand the link between environmental stress and mental health symptoms.
BeijingAges 18–60 - NCT01778504Recruiting
Study of childhood behavioral and psychiatric disorders
This study looks at brain, behavior, and genetic factors in people with neuropsychiatric or developmental disorders, as well as their biological relatives. It may help researchers better understand these conditions and find new ways to diagnose or treat them.
Bethesda, MarylandAges 4 weeks–99 years - NCT06575582Recruiting
Digital navigators for mental health apps
This trial tests if a digital navigator can help you learn to use mental health apps. It aims to improve your skills and comfort with these tools.
Brandenburg an der Havel, BrandenburgAges 18 years+ - NCT05485701Recruiting
Study of perinatal mental health in India
This study looks at mental health during pregnancy and after birth, and may help improve how these concerns are understood and assessed. You may be interviewed or asked to complete surveys across a few visits, depending on which part of the study you join.
Kangra, Himachal PradeshAges 18–45 - NCT06117163Recruiting
Mental health care for pregnant women with HIV in Kenya
This study tests a program that provides integrated mental health care for pregnant women living with HIV in Kenya. The goal is to improve both mental health and HIV treatment outcomes during pregnancy.
NairobiAges 15 years+ - NCT06752759RecruitingPhase 3
Ketamine mist for depression
This trial tests if a ketamine mist you breathe in can help treat moderate to severe depression. It is for adults who are not helped enough by other treatments.
Brooklyn, New YorkAges 18–88 - NCT06789523Recruiting
Friendship Bench for women who use methamphetamine
This trial tests a talk therapy program called the Friendship Bench for women who use methamphetamine in Vietnam. It aims to help reduce meth use and improve emotional well-being.
Haiphong, Hai PhongAges 18 years+ - NCT07195266Recruiting
Strategic therapy for adults with common mental health issues
This trial tests whether strategic therapy (a focused, problem-solving approach) helps adults with common mental health issues like anxiety, depression, or stress. If you already meet with a strategic therapist, you may be able to join to see how well the therapy works in real-world practice.
Empoli, ItalyAges 16 years+ - NCT07462312Recruiting
Wearable device training for PTSD
This trial tests a training program that uses a wearable device to help you control your body's stress responses. It's designed for people with PTSD who are eligible for military rehabilitation services.
JerusalemAges 18–50
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Common questions
- Are there clinical trials for severe mental disorder?
- Yes. Clin2 currently lists 170 recruiting severe mental disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe mental disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe mental disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.