Clinical trials
Severe Mental Disorder clinical trials
Below are recruiting severe mental disorder clinical trials, each written for real people, not researchers. We’re tracking 164 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07050342Enrolling by invitation
Nutrition and mental health clinic evaluation
This pilot study looks at how a specialized clinic that combines nutrition advice with mental health support can improve well-being. If you join, you will answer online questionnaires to help the clinic understand if this approach works.
Graz, StyriaAges 18–65 - NCT06865937Recruiting
A mobile app to help with social recovery in serious mental illness
This study tests a mobile app that provides support for social recovery in people with serious mental illness. It may help you feel less isolated and more connected.
San Diego, CaliforniaAges 18–65 - NCT06800807Recruiting
Beliefs about thinking in teens with eating disorders
This study looks at how teens with eating disorders think about their own thoughts (called metacognition). It compares their responses to a group of teens without eating disorders to better understand the role of certain beliefs in these conditions.
Oggebbio, VerbaniaAges 12–17 - NCT02431845Recruiting
Study of OCD genes, proteins, and gut microbes
This study looks at genes, blood/brain proteins, and gut microbes in people with obsessive-compulsive disorder (OCD). It may help researchers understand what drives OCD and how treatments could be better tailored in the future.
SeoulAges 19–70 - NCT05537376Recruiting
Peer-led suicide prevention support for veterans with serious mental illness
This study tests a suicide-prevention program delivered by trained peer specialists (other people with similar lived experience) to help veterans who are currently having suicidal thoughts. It aims to add ongoing support and improve safety and recovery for veterans with serious mental health conditions.
San Diego, CaliforniaAges 18 years+ - NCT07679204Recruiting
Personality and life satisfaction in bipolar and depression
This study looks at how personality traits and life satisfaction affect people with bipolar II disorder or major depression. You will fill out questionnaires about your feelings and daily life.
ElâzığAges 18 years+ - NCT06112067Recruiting
Brain implant for severe mental health conditions
This trial tests a brain implant called deep brain stimulation (DBS) for people with severe mental health conditions that have not improved with usual treatments. The goal is to see if it can reduce symptoms and improve quality of life.
ShanghaiAges 18–65 - NCT05491538Recruiting
Work-focused social skills training for veterans with mental illness
This study tests a program to help veterans with serious mental illness improve social skills for work and find jobs near the VA. It aims to see if the program is acceptable and feasible for participants.
Minneapolis, MinnesotaAges 18 years+ - NCT07006935Recruiting
Clubhouse program effects on recovery and brain health
This study looks at how Clubhouse programs (a type of community-based support) affect thinking and brain health in people with schizophrenia or related conditions. It compares Clubhouse participation to usual care. If eligible, you would complete thinking tests and possibly an MRI brain scan.
Cleveland, OhioAges 18–50 - NCT06005103Recruiting
Testing a headband that sends brain pulses for depression
This study tests a new headband that sends gentle electrical pulses to the brain (T-PEMF) to lift depression. You might join if you have moderate to severe depression and don't have certain other conditions or implants.
Frederiksberg, Capital RegionAges 18–65 - NCT06781801Recruiting
Heart and metabolic health for severe mental illness
This trial tests a long-term program to improve heart and metabolic health in adults with schizophrenia or related disorders. It may help reduce health risks often linked with severe mental illness.
GothenburgAges 18 years+ - NCT04882839RecruitingPhase 2
Therapy with psilocybin for severe OCD symptoms
This Phase 2 study tests whether psilocybin-assisted psychotherapy can reduce symptoms in adults with severe, treatment-resistant OCD. It also focuses on safety and whether this approach is practical to run.
BeershebaAges 18–65 - NCT03601026Recruiting
Genetic counseling for youth using cannabis safely
This study offers genetic counseling to help reduce mental health problems that can happen for some young people who use cannabis. You join if you are already part of the FORBOW study and fit their age and mental-health criteria.
Halifax, Nova ScotiaAges 12–21 - NCT07571226Recruiting
Urban Stress and Mental Health Monitoring Study
This study explores how city living and daily stress affect depression, anxiety, and alcohol use disorders by having you wear a monitoring wristband and use a smartphone app to track your physical responses. Researchers hope to better understand the link between environmental stress and mental health symptoms.
BeijingAges 18–60 - NCT07483333Recruiting
Comparing two group therapies for kids with medical conditions and trauma
This study compares two types of group therapy for youth ages 8–18 who have a chronic medical condition and trauma-related distress. The goal is to see which type of group helps kids feel better and handle their health challenges.
Chicago, IllinoisAges 8–18 - NCT06117163Recruiting
Mental health care for pregnant women with HIV in Kenya
This study tests a program that provides integrated mental health care for pregnant women living with HIV in Kenya. The goal is to improve both mental health and HIV treatment outcomes during pregnancy.
NairobiAges 15 years+ - NCT07610928Recruiting
Stress management and gentle movement for Asian Americans with depression
This study tests whether learning stress management and gentle movement (like Tai Chi or Qigong) can help Asian Americans with depression and physical symptoms. It may offer a way to feel better that you can do from home in online group sessions.
Boston, MassachusettsAges 18 years+ - NCT07195266Recruiting
Strategic therapy for adults with common mental health issues
This trial tests whether strategic therapy (a focused, problem-solving approach) helps adults with common mental health issues like anxiety, depression, or stress. If you already meet with a strategic therapist, you may be able to join to see how well the therapy works in real-world practice.
Empoli, ItalyAges 16 years+ - NCT07115186Recruiting
School program to build resilience in teens
This study tests a school-based program designed to help middle school students in rural China learn how to cope with stress and build resilience. If you are a middle school student attending regular classes and can hear, speak, read, and write well enough to join activities, you may be able to participate.
Hebei, BaodingAges 10–18 - NCT06907979Recruiting
Cannabis use and emotion processing study
This study looks at how heavy cannabis use affects the way you process emotions. You may be able to join if you use cannabis most days, meet criteria for cannabis use disorder, and are not currently in treatment for it. Participants will have brain scans and mild brain stimulation.
Auburn, AlabamaAges 18–50 - NCT06789523Recruiting
Friendship Bench for women who use methamphetamine
This trial tests a talk therapy program called the Friendship Bench for women who use methamphetamine in Vietnam. It aims to help reduce meth use and improve emotional well-being.
Haiphong, Hai PhongAges 18 years+ - NCT06752759RecruitingPhase 3
Ketamine mist for depression
This trial tests if a ketamine mist you breathe in can help treat moderate to severe depression. It is for adults who are not helped enough by other treatments.
Brooklyn, New YorkAges 18–88 - NCT06633458Recruiting
Family communication in teen psychiatric care
This trial looks at how teens in a hospital psychiatry unit feel about talking with their parents and whether that affects their treatment progress.
Hamburg, Free and Hanseatic City of HamburgAges 14–17 - NCT06567210Recruiting
Insomnia treatment and emotional memory regulation for mental health
This study tests whether treating insomnia can help regulate emotional memories overnight, which may reduce the risk of developing or worsening mental health conditions. You may be eligible if you have both insomnia and some anxiety symptoms.
Macquarie Park, New South WalesAges 18–45
Hear when a new Severe Mental Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for severe mental disorder?
- Yes. Clin2 currently lists 164 recruiting severe mental disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe mental disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe mental disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.