Clinical trials
Sickle Cell clinical trials
Below are recruiting sickle cell clinical trials, each written for real people, not researchers. We’re tracking 180 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06139510Recruiting
Understanding Pain in Sickle Cell Disease
This study looks at what causes pain in people with sickle cell disease. They hope to learn more about pain patterns to better help patients manage it.
Durham, North CarolinaAges 15–40 - NCT06198712RecruitingPhase 2
Testing etavopivat in children with sickle cell disease
This trial tests a new drug, etavopivat, to see how it works in children with sickle cell disease. It may help reduce painful crises and other complications.
Toronto, OntarioAges 6 months–18 years - NCT06367192Recruiting
School Readiness Program for Preschoolers with Sickle Cell
This study tests a program to help preschoolers with sickle cell disease get ready for school. It looks at whether a special learning program can help with skills like paying attention and getting along with others.
Memphis, TennesseeAges 3.5 years–6.5 years - NCT06385886Recruiting
Study to improve sickle cell care for adults not seeing a specialist
This study helps connect adults with sickle cell disease who haven't seen a specialist in over a year back into care. It tests a program designed to make it easier to get regular medical support and improve your health.
Birmingham, AlabamaAges 18 years+ - NCT06555939Recruiting
Resilience program for teens and young adults with sickle cell disease
This study tests a program called PRISM that helps teens and young adults with sickle cell disease build resilience and manage stress, anxiety, or depression. You may be eligible if you have sickle cell disease and feel down or worried.
Boston, MassachusettsAges 8–25 - NCT06565026RecruitingEarly Phase 1
CS-206 treatment for sickle cell disease patients
This trial tests CS-206, an experimental therapy for people with sickle cell disease. It aims to reduce severe complications like pain crises, acute chest syndrome, strokes, and other serious events. You may qualify if you have a specific genetic type of sickle cell disease and have experienced complications despite standard treatments.
Nanning, GuangxiAges 12–35 - NCT06578507RecruitingPhase 2
Twice-daily hydroxyurea liquid for children with sickle cell disease
This trial tests a new twice-daily liquid form of hydroxyurea (a common SCD medicine) in children ages 9 months to 11 years with sickle cell disease. It will check how the medicine works in the body, if it is safe, and if it helps reduce pain crises and other complications.
CréteilAges 9 months–11 years - NCT06612268RecruitingPhase 3
Testing etavopivat for sickle cell disease
This study tests an experimental pill called etavopivat for people with sickle cell disease who have had some pain crises in the past year. The goal is to see if it reduces these crisis episodes.
Birmingham, AlabamaAges 12 years+ - NCT06619197Recruiting
Reflexology in Sickle Cell Disease Study
This study tests if foot reflexology, a gentle pressure technique on your feet, can help relieve pain from a sickle cell crisis while in the hospital. It is only for children and teens under 18.
BronAges Up to 18 years - NCT06635902RecruitingPhase 2
Citrulline for sickle cell pain crisis
This trial tests if an intravenous medication called L-citrulline can help treat pain crises in children and young adults with sickle cell disease. Participants receive either the study drug or a placebo while in the hospital for a severe pain episode.
Washington D.C., District of ColumbiaAges 4–21 - NCT06691867Recruiting
Integrative training for sickle cell pain in teens
This study tests an integrative training program designed to help adolescents with sickle cell disease manage their pain better. It combines physical and mental techniques to reduce pain and improve quality of life.
Hartford, ConnecticutAges 12–18 - NCT06770010Recruiting
Digital brain training for kids with sickle cell disease
This trial is testing a digital program to help improve working memory (the ability to hold and use information in your mind) for children with sickle cell disease. If you join, you'll use a computer-based training program at home and researchers will see if it works and is easy to use.
Washington D.C., District of ColumbiaAges 7–16 - NCT06818266RecruitingPhase 3
Tocilizumab for severe chest crisis in sickle cell disease
This trial tests if the drug tocilizumab can help treat acute chest syndrome, a serious lung complication of sickle cell disease. It is for people with sickle cell disease who are hospitalized and need oxygen or breathing support. The study compares tocilizumab to a placebo to see if it speeds up recovery.
ParisAges 2 years+ - NCT06853158Recruiting
Music therapy study for quality of life in sickle cell disease
This study tests if music therapy can improve quality of life for people with sickle cell disease who have chronic pain. You would join a music therapy group and share your feedback to help researchers see if this approach helps.
Cleveland, OhioAges 14 years+ - NCT06887907Recruiting
Studying megakaryocytes in sickle cell disease
This trial looks at the cells that help make platelets (megakaryocytes) in people with sickle cell disease. By comparing these cells when you are feeling well and during a pain crisis or chest syndrome, researchers hope to learn more about the condition and find better treatments.
Toulouse, FranceAges 18 years+ - NCT06919224Recruiting
Text message support for adults with sickle cell disease
This study uses text messages to help adults with sickle cell disease learn about the latest medical guidelines and tools to manage their health. The goal is to see if this mobile approach improves how people follow their care plan.
Chicago, IllinoisAges 18 years+ - NCT06930703RecruitingPhase 1/Phase 2
CBD for sickle cell pain
This trial tests if cannabidiol (CBD) can help reduce pain interference in adults with sickle cell disease. You will take CBD daily for 4 weeks and report your pain levels.
Manhattan, New YorkAges 18 years+ - NCT06944067Recruiting
Genetic risk of immune response after blood transfusions in sickle cell disease
This study looks at whether certain genes make people with sickle cell disease more likely to develop an immune reaction to blood transfusions. It aims to help doctors predict transfusion risks and improve care.
Bethesda, MarylandAges 2–99 - NCT06975865RecruitingPhase 3
Rilzabrutinib for sickle-cell disease pain episodes
This study tests an oral medicine called rilzabrutinib to see if it can reduce painful episodes in people with sickle-cell disease. It may be an option if you have regular pain crises and are looking for a new treatment.
Birmingham, AlabamaAges 10–65 - NCT06979492RecruitingPhase 4
Blood transfusions for pregnant women with sickle cell disease
This study tests whether giving regular blood transfusions during early pregnancy can help prevent complications for women with sickle cell disease. If you are between 6 and 20 weeks pregnant, you may join to see if this treatment improves outcomes.
Atlanta, GeorgiaAges 18 years+ - NCT07001631Recruiting
EMDR for pain relief in children with sickle cell disease
This trial tests if EMDR therapy can help children with sickle cell disease reduce pain interference in daily life. If you or your child has sickle cell disease and experiences significant pain, this study may offer a new way to manage it.
AmsterdamAges 6–18 - NCT07023666RecruitingPhase 2
Early heart screening and treatment for sickle cell disease
This trial tests early screening and treatment to prevent heart problems in people with sickle cell disease. It focuses on those with high iron levels or heart symptoms, using regular heart imaging to monitor and treat complications early.
Fairfax, VirginiaAges 18 years+ - NCT07090668Recruiting
Ear stimulation for pain in sickle cell disease
This trial tests a safe, non-drug device that gently stimulates the ear to help reduce pain in children with sickle cell disease who are in the hospital for a pain crisis. It may offer a new way to manage pain without extra medication.
Atlanta, GeorgiaAges 7–18 - NCT07222475Recruiting
Songwriting for relaxation in sickle cell teens
This trial explores whether writing calming songs can help teenagers with sickle cell disease feel more relaxed. Teens ages 11-18 who get care at a pediatric center can join.
Rochester, MinnesotaAges 11–18
Hear when a new Sickle Cell trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for sickle cell?
- Yes. Clin2 currently lists 180 recruiting sickle cell studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sickle cell trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sickle cell trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.