Clinical trials
Smoking Cessation clinical trials
Below are recruiting smoking cessation clinical trials, each written for real people, not researchers. We’re tracking 157 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05738408Recruiting
Remote smoking help for hospitalized heart patients
This trial tests a phone-based (remote) smoking quit program for people hospitalized for a recent heart-related event. It may help you quit smoking by offering support when you’re in the hospital and afterward.
Burlington, VermontAges 18 years+ - NCT06762210Recruiting
Quit smoking with AI and dental health checks
This trial tests whether a smartphone app that uses artificial intelligence (AI) can help you quit smoking by looking at how it affects your dental health. If you smoke at least 5 cigarettes a day and want to quit, you may be able to join.
Fayoum, Alexandria GovernorateAges 21–65 - NCT05786547RecruitingPhase 3
Varenicline plus support to help quit tobacco in HIV care
This Phase 3 trial tests a quit-smoking program using varenicline (a medicine) plus additional support, for people with HIV who currently use tobacco. It may help you stop smoking or using tobacco and stay quit with safer, guided care.
Aurora, ColoradoAges 18 years+ - NCT07296848Enrolling by invitation
Health communications for adults who smoke occasionally
This study tests health messages for people who smoke some days but not every day. The goal is to help you think about your smoking and consider quitting.
Lexington, KentuckyAges 18 years+ - NCT07447635Recruiting
Testing a program to help cancer survivors quit smoking and reduce drinking
This study tests a program (MBI) to help cancer survivors quit smoking and cut back on alcohol. It's designed for people who want to make these changes in the next 30 days.
Tampa, FloridaAges 18 years+ - NCT06145763Recruiting
Quit smoking with a digital program for American Indian and Alaska Native adults
This study tests two smartphone apps to help American Indian and Alaska Native adults quit smoking. You will be randomly assigned to one of the apps and complete short surveys to see which works better.
Seattle, WashingtonAges 18 years+ - NCT06754215Recruiting
Smoking Cessation Program for Homeless Youth
This study is testing a new program to help homeless youth quit smoking. The goal is to learn what kind of support works best for young people who don't have stable housing.
Columbus, OhioAges 14–24 - NCT06582693Recruiting
Tobacco treatment for families through children's hospital
This study offers proactive, personalized help to stop smoking for adults who smoke and have a child who is a patient at Children's Hospital of Philadelphia. It aims to see if this approach works better than usual care.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06885970Recruiting
Cytisine for smoking cessation and heart health
This study tests whether a medicine called cytisine can help people quit smoking and how it might affect their heart health. If you are a smoker without serious heart, liver, kidney, or immune problems, you may be able to join.
Athens, HaidariAges 18–75 - NCT05413122RecruitingPhase 2/Phase 3
Smoking quit support for adults living with HIV in South Africa
This trial tests smoking-cessation interventions to help people living with HIV quit smoking or smoke less. You may be eligible if you smoke, are actively engaged in HIV treatment, and can follow the study for about a year.
Soweto, GautengAges 18 years+ - NCT06930547Recruiting
Smoking cessation education for recovery
This study tests whether education classes can help people who are in recovery from mental health issues quit smoking. It is for people registered with a Community Mental Health Center who smoke daily.
Erzurum, ErzurumAges 18 years+ - NCT06438549Recruiting
Community health workers help pregnant smokers quit
This study tests whether adding a community health worker to your prenatal care team can help pregnant women quit smoking. It's for women who are ready to make a quit plan and are getting care at certain hospitals.
Loma Linda, CaliforniaAges 18 years+ - NCT06173778RecruitingPhase 2
Semaglutide for weight management after quitting smoking
This study tests whether the drug semaglutide (often used for weight loss) can help people who quit smoking avoid gaining weight. It's for people who are overweight or have weight-related health issues and want to stop smoking.
Austin, TexasAges 18–75 - NCT06118502Recruiting
Adaptive quit-smoking treatment for early relapse
This trial tests a flexible treatment approach for smokers who want to quit and are at risk of relapsing early. It aims to help you stay smoke-free by adjusting the support you get.
Charleston, South CarolinaAges 21 years+ - NCT05790486Recruiting
Take a Break program for adult smokers in rural areas
This trial tests a text-based program to help adults who smoke but are not ready to quit yet. It may help you think about quitting when you’re ready, without pushing you to stop right away.
Winston-Salem, North CarolinaAges 18 years+ - NCT06820034RecruitingPhase 2/Phase 3
Smoking cessation program for LGBTQ+ adults in Arkansas, Oklahoma, Texas
This trial tests whether a program that includes nicotine replacement therapy and volunteering in the LGBTQ+ community helps people quit smoking. You need to live in Arkansas, Oklahoma, or Texas, identify as LGBTQ+, and be ready to quit within 30 days.
Oklahoma City, OklahomaAges 18–100 - NCT06361459Recruiting
Quit Smoking Before Spine Surgery
This study tests whether a program to help people quit smoking before spine surgery improves recovery. It's for adults having neck or low back surgery, but not for cancer or trauma cases.
Leiden, South HollandAges 18–75 - NCT06948058Recruiting
E-cigarettes vs nicotine therapy for quitting smoking in obesity
This study compares e-cigarettes and nicotine replacement therapy (like patches or gum) to help people who are obese quit smoking. Participants use a study product for 8 weeks and track progress with a smartphone app.
Providence, Rhode IslandAges 21 years+ - NCT06932718Recruiting
Smoking cessation program for Hong Kong workers
This study tests a workplace program to help people in Hong Kong quit smoking. It includes support through instant messaging and check-ins over 12 months.
Hong KongAges 18 years+ - NCT06873009Enrolling by invitation
Can therapy help men in prison quit smoking?
This trial tests if cognitive behavioural therapy (a type of talk therapy that changes thinking and habits) can help men in prison stop smoking. It aims to see what works best and for whom.
Paris, Île-de-France RegionAges 18 years+ - NCT07553962Recruiting
How couples support each other when quitting smoking
This study looks at how couples who both smoke can help each other quit. Researchers want to understand the ways partners support one another during a smoking cessation attempt, which may help improve quit success rates.
Denver, ColoradoAges 18 years+ - NCT05842161Recruiting
Help quitting smoking for people with HIV and TB care
This study supports quitting smoking while you are receiving HIV and/or TB care. It aims to improve engagement in care and smoking cessation for people who smoke daily.
RondeboschAges 18 years+ - NCT07007195RecruitingEarly Phase 1
Smart smell app to help you quit smoking
This study tests a smartphone app that uses your sense of smell to help you quit smoking. You'll use nicotine replacement therapy (like patches or gum) and the app to avoid relapse.
Houston, TexasAges 18 years+ - NCT07145866RecruitingPhase 4
Varenicline and TMS for quitting nicotine use
This study tests whether combining the medication varenicline (Chantix) with a special brain stimulation treatment (TMS) can help people quit vaping or smoking nicotine. If you're motivated to quit and use nicotine daily, you may be able to join.
Boston, MassachusettsAges 18–65
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Common questions
- Are there clinical trials for smoking cessation?
- Yes. Clin2 currently lists 157 recruiting smoking cessation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a smoking cessation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a smoking cessation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.